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Ebrotidine

Product Name
Ebrotidine
CAS No.
100981-43-9
Chemical Name
Ebrotidine
Synonyms
FI3542;Ulsanic;FI-3542;FI 3542;Ebrotidine;FI 3542; ULSANIC; FI-3542; FI3542;Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542;(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide;Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
CBNumber
CB71074199
Molecular Formula
C14H17BrN6O2S3
Formula Weight
477.42
MOL File
100981-43-9.mol
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Ebrotidine Property

Melting point:
142.5-146℃
Boiling point:
633.0±65.0 °C(Predicted)
Density 
1.73±0.1 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
5.25±0.40(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E320550
Product name
Ebrotidine
Packaging
500mg
Price
$1455
Updated
2021/12/16
ChemScene
Product number
CS-1391
Product name
Ebrotidine
Purity
99.43%
Packaging
50mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE65014
Product name
Ebrotidine
Packaging
50mg
Price
$333
Updated
2021/12/16
ApexBio Technology
Product number
A3380
Product name
Ebrotidine
Packaging
50mg
Price
$441
Updated
2021/12/16
ChemScene
Product number
CS-1391
Product name
Ebrotidine
Purity
99.43%
Packaging
5mg
Price
$72
Updated
2021/12/16
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Ebrotidine Chemical Properties,Usage,Production

Description

Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H+), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.

Originator

Ferrer (Spain)

Uses

Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.

Definition

ChEBI: Ebrotidine is a sulfonamide.

brand name

Ebrocit

References

[1]. patel s s, wilde m i. ebrotidine. drugs, 1996, 51(6): 974-80; discussion 981.
[2]. romero a, gómez f, villamayor f, et al. study of the population of enterochromaffin-like cells in mouse gastric mucosa after long-term treatment with ebrotidine. toxicologic pathology, 1996, 24(2): 160-165.

Ebrotidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ebrotidine Suppliers

China 35 Germany 1 United Kingdom 3 United States 9 Global 48
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58

100981-43-9, EbrotidineRelated Search:

Escin, monosodium salt Roxatidine Bromoacetonitrile Cimetidine Bromocriptine Proglumide Ebrotidine 2-GIANIDINOTHIAZOLE-4-METHYLTHIOL

  • FI 3542
  • FI3542
  • FI-3542
  • Ulsanic
  • Ebrotidine
  • N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
  • (E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
  • FI 3542; ULSANIC; FI-3542; FI3542
  • Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
  • Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542
  • 100981-43-9
  • C14H17BrN6O2S3