Ebrotidine

Product Name: Ebrotidine
CAS No.: 100981-43-9
Chemical Name: Ebrotidine
Synonyms: FI3542;Ulsanic;FI-3542;FI 3542;Ebrotidine;FI 3542; ULSANIC; FI-3542; FI3542;Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542;(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide;Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
CBNumber: CB71074199
Molecular Formula: C14H17BrN6O2S3
Formula Weight: 477.42
MOL File: 100981-43-9.mol

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Ebrotidine Property

Melting point:: 142.5-146℃
Boiling point:: 633.0±65.0 °C(Predicted)
Density: 1.73±0.1 g/cm3(Predicted)
storage temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 5.25±0.40(Predicted)
form: Solid
color: White to Off-White
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E320550
Product name: Ebrotidine
Packaging: 500mg
Price: $1455
Updated: 2021/12/16

ChemScene

Product number: CS-1391
Product name: Ebrotidine
Purity: 99.43%
Packaging: 50mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE65014
Product name: Ebrotidine
Packaging: 50mg
Price: $333
Updated: 2021/12/16

ApexBio Technology

Product number: A3380
Product name: Ebrotidine
Packaging: 50mg
Price: $441
Updated: 2021/12/16

ChemScene

Product number: CS-1391
Product name: Ebrotidine
Purity: 99.43%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

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Ebrotidine Chemical Properties,Usage,Production

Description

Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H₂-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H⁺), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.

Originator

Ferrer (Spain)

Uses

Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.

Definition

ChEBI: Ebrotidine is a sulfonamide.

brand name

Ebrocit

References

[1]. patel s s, wilde m i. ebrotidine. drugs, 1996, 51(6): 974-80; discussion 981.
[2]. romero a, gómez f, villamayor f, et al. study of the population of enterochromaffin-like cells in mouse gastric mucosa after long-term treatment with ebrotidine. toxicologic pathology, 1996, 24(2): 160-165.

Ebrotidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ebrotidine Suppliers

China 35 Germany 1 United Kingdom 3 United States 10 Global 49

J & K SCIENTIFIC LTD.

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Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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AdooQ BioScience, LLC

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AdooQ Bioscience CHINA

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Codow Chemical Co.,Ltd.

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Guangzhou QiYun Biotechnology Co., Ltd.

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Raw material medicin reagent co.,Ltd

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Chengdu Dianchun Technology Co., Ltd

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Amadis Chemical Company Limited

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100981-43-9, EbrotidineRelated Search:

Escin, monosodium salt Roxatidine Bromoacetonitrile Cimetidine Bromocriptine Proglumide Ebrotidine 2-GIANIDINOTHIAZOLE-4-METHYLTHIOL

FI 3542

FI3542

FI-3542

Ulsanic

Ebrotidine

N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide

(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide

FI 3542; ULSANIC; FI-3542; FI3542

Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-

Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542

100981-43-9

C14H17BrN6O2S3