ChemicalBook > CAS DataBase List > Ebrotidine

Ebrotidine

Product Name
Ebrotidine
CAS No.
100981-43-9
Chemical Name
Ebrotidine
Synonyms
FI3542;Ulsanic;FI-3542;FI 3542;Ebrotidine;FI 3542; ULSANIC; FI-3542; FI3542;Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542;(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide;Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
CBNumber
CB71074199
Molecular Formula
C14H17BrN6O2S3
Formula Weight
477.42
MOL File
100981-43-9.mol
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Ebrotidine Property

Melting point:
142.5-146℃
Boiling point:
633.0±65.0 °C(Predicted)
Density 
1.73±0.1 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
5.25±0.40(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E320550
Product name
Ebrotidine
Packaging
500mg
Price
$1455
Updated
2021/12/16
ChemScene
Product number
CS-1391
Product name
Ebrotidine
Purity
99.43%
Packaging
50mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE65014
Product name
Ebrotidine
Packaging
50mg
Price
$333
Updated
2021/12/16
ApexBio Technology
Product number
A3380
Product name
Ebrotidine
Packaging
50mg
Price
$441
Updated
2021/12/16
ChemScene
Product number
CS-1391
Product name
Ebrotidine
Purity
99.43%
Packaging
5mg
Price
$72
Updated
2021/12/16
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Ebrotidine Chemical Properties,Usage,Production

Description

Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H+), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.

Originator

Ferrer (Spain)

Uses

Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.

Definition

ChEBI: Ebrotidine is a sulfonamide.

brand name

Ebrocit

References

[1]. patel s s, wilde m i. ebrotidine. drugs, 1996, 51(6): 974-80; discussion 981.
[2]. romero a, gómez f, villamayor f, et al. study of the population of enterochromaffin-like cells in mouse gastric mucosa after long-term treatment with ebrotidine. toxicologic pathology, 1996, 24(2): 160-165.

Ebrotidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ebrotidine Suppliers

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J & K SCIENTIFIC LTD.
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100981-43-9, EbrotidineRelated Search:

Escin, monosodium salt Roxatidine Bromoacetonitrile Cimetidine Bromocriptine Proglumide Ebrotidine 2-GIANIDINOTHIAZOLE-4-METHYLTHIOL

  • FI 3542
  • FI3542
  • FI-3542
  • Ulsanic
  • Ebrotidine
  • N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
  • (E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
  • FI 3542; ULSANIC; FI-3542; FI3542
  • Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
  • Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542
  • 100981-43-9
  • C14H17BrN6O2S3