ChemicalBook > CAS DataBase List > Ebrotidine
Ebrotidine
- Product Name
- Ebrotidine
- CAS No.
- 100981-43-9
- Chemical Name
- Ebrotidine
- Synonyms
- FI3542;Ulsanic;FI-3542;FI 3542;Ebrotidine;FI 3542; ULSANIC; FI-3542; FI3542;Ebrotidine,FI 3542,Histamine Receptor,inhibit,Inhibitor,FI-3542;(E)-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide;Benzenesulfonamide, N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-, [N(E)]-
- CBNumber
- CB71074199
- Molecular Formula
- C14H17BrN6O2S3
- Formula Weight
- 477.42
- MOL File
- 100981-43-9.mol
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Ebrotidine Property
- Melting point:
- 142.5-146℃
- Boiling point:
- 633.0±65.0 °C(Predicted)
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 5.25±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Light Sensitive
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N-Bromosuccinimide Price
TRC
- Product number
- E320550
- Product name
- Ebrotidine
- Packaging
- 500mg
- Price
- $1455
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-1391
- Product name
- Ebrotidine
- Purity
- 99.43%
- Packaging
- 50mg
- Price
- $300
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FE65014
- Product name
- Ebrotidine
- Packaging
- 50mg
- Price
- $333
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3380
- Product name
- Ebrotidine
- Packaging
- 50mg
- Price
- $441
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-1391
- Product name
- Ebrotidine
- Purity
- 99.43%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
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Ebrotidine Chemical Properties,Usage,Production
Description
Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus production, enhanced physiochemical properties (decreased permeability of H+), and an increase in mucin glycosylation and sulfation. It acts on gastric mucosal EGF and PDGF receptor expression. Nitric oxide was also found to be involved. Ebrocit caused enhanced mucosal blood flow with anti H.pylori activity. It has diminished P450 binding which eliminates the possibility of mutagenic nitrosoamine formation.
Originator
Ferrer (Spain)
Uses
Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.
Definition
ChEBI: Ebrotidine is a sulfonamide.
brand name
Ebrocit
References
[1]. patel s s, wilde m i. ebrotidine. drugs, 1996, 51(6): 974-80; discussion 981.
[2]. romero a, gómez f, villamayor f, et al. study of the population of enterochromaffin-like cells in mouse gastric mucosa after long-term treatment with ebrotidine. toxicologic pathology, 1996, 24(2): 160-165.
Ebrotidine Preparation Products And Raw materials
Raw materials
Preparation Products
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