eperezolid

Product Name: eperezolid
CAS No.: 165800-04-4
Chemical Name: eperezolid
Synonyms: U 100592;PNU 100592;eperezolid;Eperezolid-d3;Eperezolid (PNU-100592;PNU-100592;PNU100592;U-100592;PNU-100592; PNU100592; PNU 100592;Bacterial,PNU100592,Inhibitor,inhibit,Eperezolid,PNU 100592,Antibiotic;(S)-N-[[3-[3-Fluoro-4-[4-(hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CBNumber: CB71074285
Molecular Formula: C18H23FN4O5
Formula Weight: 394.4
MOL File: 165800-04-4.mol

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eperezolid Property

Melting point:: 174-176℃
Boiling point:: 701.2±60.0 °C(Predicted)
Density: 1.370±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.05 mg/mL in DMSO
form: Powder
pka: 13.84±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E565742
Product name: Eperezolid-d3
Packaging: 1mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-2793
Product name: Eperezolid
Purity: 96.23%
Packaging: 5mg
Price: $348
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0136369
Product name: ACETAMIDE, N-[[(5S)-3-[3-FLUORO-4-[4-(2-HYDROXYACETYL)-1-PIPERAZINYL]PHENYL]-2-OXO-5-OXAZOLIDINYL]METHYL]-
Purity: 95.00%
Packaging: 5MG
Price: $499.75
Updated: 2021/12/16

ChemScene

Product number: CS-2793
Product name: Eperezolid
Purity: 96.23%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611774
Product name: Eperezolid
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

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eperezolid Chemical Properties,Usage,Production

Uses

Antibacterial.

Uses

Eperezolid is an antimicrobial.

Biological Activity

mic50: 0.5, 1.0, 2.0, 1.0, 16.0 and 2.0 mg/l for pcptostreptococcus, propionibacterium acnes, ciostridium pefringens, clostridium dijiicile, bactrroidesjagilis, and fusobacterium, respectivleyanaerobic bacteria are a common cause of serious infections. anaerobic species which predominate in clinical infections include the bacteroides fragilis group, clostridium spp. and peptostreptococcus spp. the oxazolidinones are a novel class of synthetic antimicrobials inhibiting the initiation of protein synthesis. two compounds of this class, eperezolid and linezolid have been shown to inhibit enterococcus faecalis and enterococcus faecium.

in vitro

ninety per cent of all tested propionibacterium acnes (30 strains), peptostreptococccuj spp. (50 strains), c. perjringens (50 strains) and c. dficile (50 strains) were inhibited by <2 mg/l eperezolid. linezolid showed higher activity (mic90 4.0 mg/l) against b. jragilis (100 strains) compared to eperezolid (mic90 16 mg/l) [1].

in vivo

the in vivo effectiveness of eperezolid and linezolid against one strain each of enterococcus faecalis and vancomycin-resistant enterococcus faecium was examined in a rat intraabdominal abscess model. eperezolid was ineffective at doses of 25 mg/kg of body weight twice daily for the reductions in abscess bacterial density for e. faecalis. against e. faecium infections, intravenous eperezolid was effective, reducing densities approximately 2 log10 cfu/g [2].

References

[1] edlund c, oh h, nord ce. in vitro activity of linezolid and eperezolid against anaerobic bacteria. clin microbiol infect. 1999;5(1):51-53.
[2] schülin t, thauvin-eliopoulos c, moellering rc jr, eliopoulos gm. activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to enterococcus faecalis or vancomycin-resistant enterococcus faecium. antimicrob agents chemother. 1999;43(12):2873-6.
[3] schaadt rd, batts dh, daley-yates pt, pawsey sd, stalker dj, zurenko ge. serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid. diagn microbiol infect dis. 1997;28(4):201-4.

eperezolid Preparation Products And Raw materials

Raw materials

Preparation Products

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eperezolid Suppliers

China 54 Germany 1 India 1 United Kingdom 1 United States 14 Global 71

AdooQ BioScience, LLC

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Musechem

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Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alchem Pharmtech,Inc.

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Country: United States
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ApexBio Technology

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Abblis Chemicals LLC

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Alfa Chemistry

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2A PharmaChem USA

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3B Scientific Corporation

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United States Biological

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MedChemExpress

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Matrix Scientific

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Waterstone Technology, LLC

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165800-04-4, eperezolidRelated Search:

Ethambutol diHCl Ethyl 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropane-1-carboxylate 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE 2-FLUORO-BENZENE-1,4-DIAMINE (S)-N-[[3-(3-Fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol ETHYL (4-AMINOPHENYL)CARBAMATE N1,N1-DIETHYL-2-FLUORO-1,4-BENZENEDIAMINE 3-PHENYL-2-OXAZOLIDINONE Dimethyl-(4-piperazin-1-yl-phenyl)-amine 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 2-FLUORO-N1,N1-DIMETHYL-1,4-BENZENEDIAMINE (S)-5-(AMINOMETHYL)-3-(3-FLUOROPHENYL)OXAZOLIDIN-2-ONE eperezolid

eperezolid

N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-Acetamide

PNU 100592

(S)-N-[[3-[3-Fluoro-4-[4-(hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

U 100592

Eperezolid-d3

Eperezolid (PNU-100592

(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

PNU-100592;PNU100592;U-100592

PNU-100592; PNU100592; PNU 100592

Acetamide, N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]-

N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Bacterial,PNU100592,Inhibitor,inhibit,Eperezolid,PNU 100592,Antibiotic

165800-04-4

C18H23FN4O5