ChemicalBook > CAS DataBase List > Ki8751

Ki8751

Product Name
Ki8751
CAS No.
228559-41-9
Chemical Name
Ki8751
Synonyms
Ki8751;CS-532;Ki8751, >=98%;Ki8751 hydrate;KI 8751; KI-8751;Ki8751 USP/EP/BP;KI8751;KI 8751;KI-8751;VEGFR2 Kinase Inhibitor VI, Ki8751;VEGFR2 Kinase Inhibitor VI Ki8751 Ki-8751;VEGFR2 Kinase Inhibitor VI, Ki8751 - CAS 228559-41-9 - Calbiochem
CBNumber
CB71074331
Molecular Formula
C24H18F3N3O4
Formula Weight
469.41
MOL File
228559-41-9.mol
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Ki8751 Property

Melting point:
239℃
Density 
1.429
storage temp. 
−20°C
solubility 
Soluble in DMSO (15 mg/ml)
form 
Off-white solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-38
Safety Statements 
37
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
676484
Product name
VEGFR2 Kinase Inhibitor VI, Ki8751
Packaging
5mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
18004
Product name
Ki8751
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
18004
Product name
Ki8751
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
18004
Product name
Ki8751
Purity
≥98%
Packaging
25mg
Price
$234
Updated
2024/03/01
Cayman Chemical
Product number
18004
Product name
Ki8751
Purity
≥98%
Packaging
50mg
Price
$437
Updated
2024/03/01
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Ki8751 Chemical Properties,Usage,Production

Description

Ki8751 (228559-41-9) is a very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRα (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts @ 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFR?/GM3-dependent manner.2

Uses

Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

Uses

KI 8751 is a potent and selective inhibitor of VEGFR-2-tyrosine kinase which inhibits proliferation of human umbilical vein endothelial cells and inhibits tumor growth.

Definition

ChEBI: 1-(2,4-difluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea is an aromatic ether.

General Description

A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRα, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 μM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo.

Biological Activity

Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC 50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFR α and FGFR-2 (IC 50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC 50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo ; antiangiogenic.

storage

Store at +4°C

References

Kubo et al. (2005), Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N’{4-(4-quinolyloxy)phenyl}ureas; J. Med. Chem. 48 1359 Vrijens et al. (2019), Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor b signaling pathway; J. Gen. Virol. 100 583

Ki8751 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ki8751 Suppliers

China 96 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 19 Global 120
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
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58
MedChemExpress
Tel
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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Riedel-de Haen AG
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Country
United States
ProdList
6773
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87
Matrix Scientific
Tel
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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80
Selleck Chemicals LLC
Tel
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Email
info@selleckchem.com
Country
United States
ProdList
824
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60
Exlcusive Chemistry Ltd
Tel
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Country
United States
ProdList
446
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Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
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View Lastest Price from Ki8751 manufacturers

Career Henan Chemical Co
Product
Ki8751 228559-41-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 524
Release date
2019-09-01

228559-41-9, Ki8751Related Search:

KU57788(NU7441) RESINIFERATOXIN N-Eicosanoyl Serotonin ML335 AZD-4547 CP-673451 Nintedanib KRN 633 Lenvatinib Olaparib 4-Hydroxy-6,7-dimethoxyqunioline 4,7-DIMETHOXYQUINOLINE Ki8751 (2-fluoro-4-methoxyphenyl)methanamine 4,6-DIMETHOXYQUINOLINE

  • Ki8751 hydrate
  • Ki8751, >=98%
  • KI8751;KI 8751;KI-8751
  • VEGFR2 Kinase Inhibitor VI, Ki8751
  • Ki8751
  • 1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea hydrate
  • N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
  • 1-(2,4-difluorophenyl)-3-(4-(6,7-diMethoxyquinolin-4-yloxy)-2-fluorophenyl)urea
  • N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea KI8751
  • VEGFR2 Kinase Inhibitor VI, Ki8751 - CAS 228559-41-9 - Calbiochem
  • KI 8751; KI-8751
  • CS-532
  • Urea, N-(2,4-difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]-
  • Ki8751 USP/EP/BP
  • VEGFR2 Kinase Inhibitor VI Ki8751 Ki-8751
  • 228559-41-9
  • 28559-41-9
  • C24H18F3N3O4
  • Inhibitors