4-Hydroxy-6,7-dimethoxyqunioline

Appearance

Product Name: 4-Hydroxy-6,7-dimethoxyqunioline
CAS No.: 13425-93-9
Chemical Name: 4-Hydroxy-6,7-dimethoxyqunioline
Synonyms: Lactic Acid Impurity 22;6,7-DIMETHOXYQUINOLINE-4-OL;4-Quinolinol,6,7-diMethoxy-;6,7-Dimethoxy-quinolin-4-ol;Cabozantinib Hydroxy Analog;6,7-DIMETHOXYQUINOLIN-4(1H)-ONE;4-HYDROXY-6,7-DIMETHOXYQUNIOLINE;4-HYDROXY-6,7-DIMETHOXYQUINOLINE;4-hydroxy-(6,7-dimethoxyqunioine;6,7-Dimethoxy-4-hydroxyquinoline
CBNumber: CB4704786
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 13425-93-9.mol

More

Less

4-Hydroxy-6,7-dimethoxyqunioline Property

Melting point:: 227.0 to 231.0 °C
Boiling point:: 370.9±37.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: powder to crystal
pka: 4.26±0.40(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C11H11NO3/c1-14-10-5-7-8(6-11(10)15-2)12-4-3-9(7)13/h3-6H,1-2H3,(H,12,13)
InChIKey: QOGPNCUTXVZQSL-UHFFFAOYSA-N
SMILES: N1C2C(=CC(OC)=C(OC)C=2)C(O)=CC=1
CAS DataBase Reference: 13425-93-9(CAS DataBase Reference)

More

Less

Safety

HS Code: 2933.49.7000
HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D4695
Product name: 6,7-Dimethoxy-4-hydroxyquinoline
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: D4695
Product name: 6,7-Dimethoxy-4-hydroxyquinoline
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $613
Updated: 2025/07/31

TRC

Product number: D480763
Product name: 6,7-Dimethoxy-4-quinolinol
Packaging: 50g
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: J54673
Product name: 4-Hydroxy-6,7-dimethoxyquinoline
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: 317928
Product name: 6,7-Dimethoxyquinolin-4-ol
Purity: 95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

More

Less

4-Hydroxy-6,7-dimethoxyqunioline Chemical Properties,Usage,Production

Appearance

4-Hydroxy-6,7-dimethoxyqunioline is a slightly pale yellow to yellow solid.

Uses

4-Hydroxy-6,7-dimethoxyqunioline, also called 6,7-Dimethoxy-4-quinolinol was used in the study of synthesis of ring-substituted 4-aminoquinolines and evaluation fo their antimalarial activities.

Synthesis

13436-14-1

13425-93-9

General procedure for the synthesis of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate (700 mg, 2.53 mmol) was added to potassium hydroxide (450 mg, 7.6 mmol) dissolved in 20 mL of H2O/EtOH (1:1, v /v) solution. The mixture was placed in a sealed container (XP-500 Plus container) and heated using microwaves (MARS 5 Microwave System) at 180°C, 260-280 psi pressure for 50 min. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a flask. Subsequently, the solution was acidified to pH about 6 with acetic acid (about 2 mL), saturated with sodium chloride, and extracted with tetrahydrofuran (3 x 100 mL). The organic layers were combined, washed with brine and concentrated to give 6,7-dimethoxyquinolin-4-ol in 90% yield.1H NMR (400 MHz, DMSO-d6) δ ppm: 3.81 (s, 3H), 3.84 (s, 3H), 5.93 (d, J=7.3 Hz, 1H), 7.05 (s, 1H), 7.42 (s, 1H), and 7.76 (d, J=7.3 Hz, 1H).

storage

Store at room temperature.

References

[1] Patent: WO2005/121125, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1264

4-Hydroxy-6,7-dimethoxyqunioline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Hydroxy-6,7-dimethoxyqunioline Suppliers

Americas 1 China 278 Europe 2 India 18 Japan 1 United Kingdom 5 United States 21 Global 326

Shandong Xuande Pharmaceutical Technology Co. LTD

Tel: 18866895588
Fax: 0531-82777287
Email: dingjiaying@shiningpharm.com
Country: China
ProdList: 163
Advantage: 55

Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd.

Tel: 18001856580
Fax: QQ：2415195517
Email: 2415195517@qq.com
Country: China
ProdList: 44
Advantage: 58

Ningbo jinuo chemical co., LTD

Tel: 0574-87314919 057487319282
Email: info@nbinno.com
Country: China
ProdList: 7047
Advantage: 58

shanghai huiyu

Tel: 15380804498
Email: 330062898@qq.com
Country: China
ProdList: 241
Advantage: 58

Anhui Shuangmai Intelligent Technology Co., LTD

Tel: 19956280676
Email: sales@nbinno.com
Country: China
ProdList: 101
Advantage: 58

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from 4-Hydroxy-6,7-dimethoxyqunioline manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-21

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Henan Fengda Chemical Co., Ltd

Product: 4-Hydroxy-6,7-dimethoxyquinoline 13425-93-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

13425-93-9, 4-Hydroxy-6,7-dimethoxyquniolineRelated Search:

8-Hydroxyquinoline Ethoxyquin Dimethyldimethoxysilane 1,1-Dimethoxyethane CHLOROPHOSPHONAZO III 7-Methoxy-4-quinolinol Quinhydrone 4-Hydroxyquinoline Dimethoxymethane Decoquinate buquinolate Ciproquinate Proquinolate 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid 6,7-DIMETHOXY-4-HYDROXY-3-NITROQUINOLINE KOKUSAGININE Ki8751 4-Hydroxy-6,7-dimethoxyqunioline

6,7-Dimethoxy-4-hydroxyquinoline

4-hydroxy-(6,7-dimethoxyqunioine

6,7-DIMETHOXYQUINOLIN-4(1H)-ONE

4-HYDROXY-6,7-DIMETHOXYQUINOLINE

4-HYDROXY-6,7-DIMETHOXYQUNIOLINE

6,7-Dimethoxy-quinolin-4-ol

4-Quinolinol,6,7-diMethoxy-

6,7-DIMETHOXYQUINOLINE-4-OL

4-Cydroxy-6,7-dimethoxyqunioline

6,7-Dimethoxy-4-hydroxyquinoline&gt

4-Hydroxy-6,7-dimethoxyqunioline ISO 9001：2015 REACH

Cabozantinib Hydroxy Analog

4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9

Lactic Acid Impurity 22

13425-93-9

134325-93-9

Quinoline series

Heterocycles