ChemicalBook > CAS DataBase List > 4-Hydroxy-6,7-dimethoxyqunioline

4-Hydroxy-6,7-dimethoxyqunioline

Appearance

Product Name: 4-Hydroxy-6,7-dimethoxyqunioline
CAS No.: 13425-93-9
Chemical Name: 4-Hydroxy-6,7-dimethoxyqunioline
Synonyms: Lactic Acid Impurity 22;6,7-DIMETHOXYQUINOLINE-4-OL;4-Quinolinol,6,7-diMethoxy-;6,7-Dimethoxy-quinolin-4-ol;Cabozantinib Hydroxy Analog;6,7-DIMETHOXYQUINOLIN-4(1H)-ONE;4-HYDROXY-6,7-DIMETHOXYQUNIOLINE;4-HYDROXY-6,7-DIMETHOXYQUINOLINE;4-hydroxy-(6,7-dimethoxyqunioine;6,7-Dimethoxy-4-hydroxyquinoline
CBNumber: CB4704786
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 13425-93-9.mol

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4-Hydroxy-6,7-dimethoxyqunioline Property

Melting point:: 227.0 to 231.0 °C
Boiling point:: 370.9±37.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: powder to crystal
pka: 4.26±0.40(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C11H11NO3/c1-14-10-5-7-8(6-11(10)15-2)12-4-3-9(7)13/h3-6H,1-2H3,(H,12,13)
InChIKey: QOGPNCUTXVZQSL-UHFFFAOYSA-N
SMILES: N1C2C(=CC(OC)=C(OC)C=2)C(O)=CC=1
CAS DataBase Reference: 13425-93-9(CAS DataBase Reference)

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Safety

HS Code: 2933.49.7000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4695
Product name: 6,7-Dimethoxy-4-hydroxyquinoline
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: D4695
Product name: 6,7-Dimethoxy-4-hydroxyquinoline
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $613
Updated: 2025/07/31

TRC

Product number: D480763
Product name: 6,7-Dimethoxy-4-quinolinol
Packaging: 50g
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: J54673
Product name: 4-Hydroxy-6,7-dimethoxyquinoline
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: 317928
Product name: 6,7-Dimethoxyquinolin-4-ol
Purity: 95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-Hydroxy-6,7-dimethoxyqunioline Chemical Properties,Usage,Production

Appearance

4-Hydroxy-6,7-dimethoxyqunioline is a slightly pale yellow to yellow solid.

Uses

4-Hydroxy-6,7-dimethoxyqunioline, also called 6,7-Dimethoxy-4-quinolinol was used in the study of synthesis of ring-substituted 4-aminoquinolines and evaluation fo their antimalarial activities.

Synthesis

13436-14-1

13425-93-9

General procedure for the synthesis of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate (700 mg, 2.53 mmol) was added to potassium hydroxide (450 mg, 7.6 mmol) dissolved in 20 mL of H2O/EtOH (1:1, v /v) solution. The mixture was placed in a sealed container (XP-500 Plus container) and heated using microwaves (MARS 5 Microwave System) at 180°C, 260-280 psi pressure for 50 min. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a flask. Subsequently, the solution was acidified to pH about 6 with acetic acid (about 2 mL), saturated with sodium chloride, and extracted with tetrahydrofuran (3 x 100 mL). The organic layers were combined, washed with brine and concentrated to give 6,7-dimethoxyquinolin-4-ol in 90% yield.1H NMR (400 MHz, DMSO-d6) δ ppm: 3.81 (s, 3H), 3.84 (s, 3H), 5.93 (d, J=7.3 Hz, 1H), 7.05 (s, 1H), 7.42 (s, 1H), and 7.76 (d, J=7.3 Hz, 1H).

storage

Store at room temperature.

References

[1] Patent: WO2005/121125, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1264

4-Hydroxy-6,7-dimethoxyqunioline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Hydroxy-6,7-dimethoxyqunioline manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-21

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Henan Fengda Chemical Co., Ltd

Product: 4-Hydroxy-6,7-dimethoxyquinoline 13425-93-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

13425-93-9, 4-Hydroxy-6,7-dimethoxyquniolineRelated Search:

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6,7-Dimethoxy-4-hydroxyquinoline

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6,7-DIMETHOXYQUINOLIN-4(1H)-ONE

4-HYDROXY-6,7-DIMETHOXYQUINOLINE

4-HYDROXY-6,7-DIMETHOXYQUNIOLINE

6,7-Dimethoxy-quinolin-4-ol

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6,7-Dimethoxy-4-hydroxyquinoline&gt

4-Hydroxy-6,7-dimethoxyqunioline ISO 9001：2015 REACH

Cabozantinib Hydroxy Analog

4-Hydroxy-6,7-dimethoxyqunioline 13425-93-9

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13425-93-9

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