PD158780
- Product Name
- PD158780
- CAS No.
- 171179-06-9
- Chemical Name
- PD158780
- Synonyms
- PD 158780 solution;PD 158780; PD-158780;InSolution? PD 158780;PD 158780 - CAS 171179-06-9 - Calbiochem;PD 158780, ErbB receptor tyrosine kinase inhibitor;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference);PD158780,Inhibitor,Epidermal growth factor receptor,inhibit,HER1,EGFR,PD 158780,ErbB-1,PD-158780
- CBNumber
- CB71074528
- Molecular Formula
- C14H12BrN5
- Formula Weight
- 330.18
- MOL File
- 171179-06-9.mol
PD158780 Property
- Melting point:
- 174.0 to 178.0 °C
- Boiling point:
- 499.6±45.0 °C(Predicted)
- Density
- 1.611±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: ≥20mg/mL
- form
- Yellow solid
- pka
- 5.80±0.30(Predicted)
- color
- yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 513035
- Product name
- PD 158780 - CAS 171179-06-9 - Calbiochem
- Purity
- A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM).
- Packaging
- 500μg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 513036
- Product name
- InSolution PD 158780 - CAS 171179-06-9 - Calbiochem
- Packaging
- 500μg
- Price
- $195
- Updated
- 2023/01/07
- Product number
- P2567
- Product name
- PD 158780
- Purity
- >97.0%(HPLC)
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- P2567
- Product name
- PD 158780
- Purity
- >97.0%(HPLC)
- Packaging
- 50mg
- Price
- $808
- Updated
- 2024/03/01
- Product number
- 13329
- Product name
- PD 158780
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
PD158780 Chemical Properties,Usage,Production
Uses
PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.
Definition
ChEBI: PD158780 is a pyridopyrimidine that is pyrido[3,4-d]pyrimidine-4,6-diamine in which the amino groups at positions 4 and 6 are substituted by a m-bromophenyl group and a methyl group, respectively. It is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity [IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4)]. It does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a pyridopyrimidine, a secondary amino compound, a member of bromobenzenes, a diamine and an aromatic amine.
General Description
A potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
Biological Activity
Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
PD158780 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PD158780 manufacturers
- Product
- PD158780 171179-06-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-28