ChemicalBook > CAS DataBase List > PD158780

PD158780

Product Name
PD158780
CAS No.
171179-06-9
Chemical Name
PD158780
Synonyms
PD 158780 solution;PD 158780; PD-158780;InSolution? PD 158780;PD 158780 - CAS 171179-06-9 - Calbiochem;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference);PD158780,Inhibitor,Epidermal growth factor receptor,inhibit,HER1,EGFR,PD 158780,ErbB-1,PD-158780
CBNumber
CB71074528
Molecular Formula
C14H12BrN5
Formula Weight
330.18
MOL File
171179-06-9.mol
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PD158780 Property

Melting point:
174.0 to 178.0 °C
Boiling point:
499.6±45.0 °C(Predicted)
Density 
1.611±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: ≥20mg/mL
form 
Yellow solid
pka
5.80±0.30(Predicted)
color 
yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2912.49.2600
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
513035
Product name
PD 158780 - CAS 171179-06-9 - Calbiochem
Purity
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM).
Packaging
500μg
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
513036
Product name
InSolution PD 158780 - CAS 171179-06-9 - Calbiochem
Packaging
500μg
Price
$195
Updated
2023/01/07
TCI Chemical
Product number
P2567
Product name
PD 158780
Purity
>97.0%(HPLC)
Packaging
10mg
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
P2567
Product name
PD 158780
Purity
>97.0%(HPLC)
Packaging
50mg
Price
$808
Updated
2024/03/01
Cayman Chemical
Product number
13329
Product name
PD 158780
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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PD158780 Chemical Properties,Usage,Production

Uses

PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.

Definition

ChEBI: PD158780 is a pyridopyrimidine that is pyrido[3,4-d]pyrimidine-4,6-diamine in which the amino groups at positions 4 and 6 are substituted by a m-bromophenyl group and a methyl group, respectively. It is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity [IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4)]. It does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a pyridopyrimidine, a secondary amino compound, a member of bromobenzenes, a diamine and an aromatic amine.

General Description

A potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.

Biological Activity

Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

PD158780 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD158780 Suppliers

China 52 Germany 1 India 2 Japan 1 United Kingdom 2 United States 13 Global 71
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from PD158780 manufacturers

Career Henan Chemical Co
Product
PD158780 171179-06-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

171179-06-9, PD158780Related Search:

PD153035 HCl PD 98059 2-Bromopyridine Phenylimidazole 2-Phenylpyridine Pyridine PD158780

  • N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
  • Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference)
  • Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-
  • PD 158780 solution
  • InSolution? PD 158780
  • PD 158780 - CAS 171179-06-9 - Calbiochem
  • InSolution PD 158780 - CAS 171179-06-9 - Calbiochem
  • PD 158780; PD-158780
  • PD158780,Inhibitor,Epidermal growth factor receptor,inhibit,HER1,EGFR,PD 158780,ErbB-1,PD-158780
  • 171179-06-9