ChemicalBook > CAS DataBase List > 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)

Product Name: 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
CAS No.: 252061-66-8
Chemical Name: 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
Synonyms: 5-hydroxyisoindolin-1-one;5-Hydroxy-2,3-dihydroisoindol-1-one;5-Hydroxy-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
CBNumber: CB71087658
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 252061-66-8.mol

Less

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Property

Boiling point:: 519.4±50.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 9.03±0.20(Predicted)
form: solid
color: White

Less

Safety

HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

TRC

Product number: H805135
Product name: 5-Hydroxyisoindolin-1-one
Packaging: 100mg
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR305282
Product name: 5-Hydroxyisoindolin-1-one
Packaging: 250mg
Price: $101
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-08
Product name: 5-Hydroxy-2,3-dihydro-1H-isoindol-1-one
Packaging: 250mg
Price: $122
Updated: 2021/12/16

AK Scientific

Product number: Z4499
Product name: 5-Hydroxyisoindolin-1-one
Packaging: 250mg
Price: $158
Updated: 2021/12/16

Apolloscientific

Product number: OR305282
Product name: 5-Hydroxyisoindolin-1-one
Packaging: 1g
Price: $248
Updated: 2021/12/16

Less

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Chemical Properties,Usage,Production

Uses

5-Hydroxyisoindolin-1-one, can be used in the synthesis of chemical compounds, such as in design and Synthesis of Pyrrolo[3,2-d]pyrimidine Human Epidermal Growth Factor Receptor.

Synthesis

22246-66-8

252061-66-8

General procedure for the synthesis of 5-hydroxy-isoindolin-1-one from 5-methoxy-2,3-dihydroisoindol-1-one: To a suspension of 5-methoxy-2,3-dihydroisoindol-1-one (5.65 g, 34.6 mmol) in dichloromethane (300 mL) was added slowly and dropwise over a period of 20 min boron tribromide (25.1 g, 100 mmol, 1.0 M dichloromethane solution). After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. Subsequently, the reaction was quenched with methanol (100 mL) at 0 °C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction solution was concentrated, water (500 mL) was added, heated to 60 °C and kept for 1 hour. After cooling, the solid product 5-hydroxy-2,3-dihydroisoindol-1-one was obtained by filtration (4.10 g, 79% yield, CAS No. 252061-66-8). Mass spectrometry (electrospray ionization): m/z 150.0 [M+H]+ (calculated value: 149.0).

References

[1] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 35-36
[2] Patent: WO2004/14856, 2004, A1. Location in patent: Page 9; 14-15
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 8, p. 3975 - 3991
[4] Journal of Medicinal Chemistry, 1999, vol. 42, # 23, p. 4875 - 4889
[5] Chemical and Pharmaceutical Bulletin, 2011, vol. 59, # 1, p. 96 - 99

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Suppliers

China 65 Europe 1 India 1 United Kingdom 1 United States 5 Global 73

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Heterochem

Tel: 027-88041443 13072715837
Fax: 027-51829379
Email: sales@hetero-chem.com
Country: China
ProdList: 696
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai ChriChem Co., Ltd.

Tel: 021-54880687
Fax: 021-54880687
Country: China
ProdList: 511
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.

Tel: 02161555100
Fax: -
Country: China
ProdList: 820
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4895
Advantage: 55

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Shanghai Chenzhu Pharmaceutical Co., Ltd.

Tel: 13162380607
Fax: QQ:1696175688
Email: 1696175688@qq.com
Country: China
ProdList: 817
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

LinkChem Technology Co., Ltd.

Tel: 021-58950110 13124863828
Fax: 021-20922272
Email: sales@linkchem.cn
Country: China
ProdList: 3000
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai silk sail pharmaceutical technology co., LTD

Tel: 18916696128
Email: service@snowpharm.com
Country: China
ProdList: 1369
Advantage: 58

Shanghai Sealing Biotechnology Co. Ltd..

Tel: 15721176654
Email: 1815535157@qq.com
Country: China
ProdList: 881
Advantage: 58

wuhan Dekray Biomedical Technology Co.,Ltd

Tel: 027-69573188 18221423799
Email: 1503407886@qq.com
Country: China
ProdList: 1726
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Shanghai Xiushi Biomedical Co., LTD

Tel: 15002184385 15021598081 15002184385
Email: product001@xiushipharm.com
Country: China
ProdList: 4719
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Ruipu Medical Technology Co., Ltd

Tel: 15895968936
Fax: qq 1018762393
Email: 1018762393@qq.com
Country: China
ProdList: 9999
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 15870833005
Email: 2232044025@qq.com
Country: China
ProdList: 8206
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Huasige Pharmaceutical Technology Co., LTD

Tel: 13611612777
Email: 3627377363@qq.com
Country: China
ProdList: 4015
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188 13327728092
Email: sales@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Shanghai Shengxiu Biotechnology Co., Ltd.

Tel: 13761144602
Email: 3896578657@qq.com
Country: China
ProdList: 4483
Advantage: 58

Changzhou Extraordinary Pharmatech co., LTD.

Tel: 0519-82111935 15195055733
Fax: 051982611250
Email: info@feifanchem.com
Country: China
ProdList: 618
Advantage: 58

Less

View Lastest Price from 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) manufacturers

Career Henan Chemical Co

Product: 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) 252061-66-8
Price: US $1.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2019-12-20

252061-66-8, 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)Related Search:

Falipamil 2,2-BIS[4-(N-METHYLPHTHALIMIDO-4-OXY)PHENYL]PROPANE 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) 6-METHOXYISOINDOLIN-1-ONE 4,5-DIMETHOXY-ISOINDOLIN-1-ONE 5,6-DIMETHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE 5-HYDROXY-1H-ISOINDOLE-1,3(2H)-DIONE DPS-CL AKOS 227-93 AKOS 245-26 AKOS 200-57 AKOS 237-117 AKOS 212-82 SALOR-INT L170852-1EA 5-(4-AMINOPHENOXY)-2-(4-METHYLPHENYL)-1H-ISOINDOLE-1,3(2H)-DIONE AKOS 220-68 AKOS 213-160 AKOS 213-64

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)

1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-

5-Hydroxy-2,3-dihydro-1H-isoindol-1-one

5-Hydroxy-2,3-dihydroisoindol-1-one

5-hydroxyisoindolin-1-one

252061-66-8

ALCOHOL