1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
- Product Name
- 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
- CAS No.
- 252061-66-8
- Chemical Name
- 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
- Synonyms
- 5-hydroxyisoindolin-1-one;5-Hydroxy-2,3-dihydroisoindol-1-one;5-Hydroxy-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy-;1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI)
- CBNumber
- CB71087658
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 252061-66-8.mol
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Property
- Boiling point:
- 519.4±50.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.03±0.20(Predicted)
- form
- solid
- color
- White
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- H805135
- Product name
- 5-Hydroxyisoindolin-1-one
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR305282
- Product name
- 5-Hydroxyisoindolin-1-one
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 4H48-1-08
- Product name
- 5-Hydroxy-2,3-dihydro-1H-isoindol-1-one
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- Z4499
- Product name
- 5-Hydroxyisoindolin-1-one
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- OR305282
- Product name
- 5-Hydroxyisoindolin-1-one
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Chemical Properties,Usage,Production
Uses
5-Hydroxyisoindolin-1-one, can be used in the synthesis of chemical compounds, such as in design and Synthesis of Pyrrolo[3,2-d]pyrimidine Human Epidermal Growth Factor Receptor.
Synthesis
22246-66-8
252061-66-8
General procedure for the synthesis of 5-hydroxy-isoindolin-1-one from 5-methoxy-2,3-dihydroisoindol-1-one: To a suspension of 5-methoxy-2,3-dihydroisoindol-1-one (5.65 g, 34.6 mmol) in dichloromethane (300 mL) was added slowly and dropwise over a period of 20 min boron tribromide (25.1 g, 100 mmol, 1.0 M dichloromethane solution). After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. Subsequently, the reaction was quenched with methanol (100 mL) at 0 °C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction solution was concentrated, water (500 mL) was added, heated to 60 °C and kept for 1 hour. After cooling, the solid product 5-hydroxy-2,3-dihydroisoindol-1-one was obtained by filtration (4.10 g, 79% yield, CAS No. 252061-66-8). Mass spectrometry (electrospray ionization): m/z 150.0 [M+H]+ (calculated value: 149.0).
References
[1] Patent: WO2008/20306, 2008, A2. Location in patent: Page/Page column 35-36
[2] Patent: WO2004/14856, 2004, A1. Location in patent: Page 9; 14-15
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 8, p. 3975 - 3991
[4] Journal of Medicinal Chemistry, 1999, vol. 42, # 23, p. 4875 - 4889
[5] Chemical and Pharmaceutical Bulletin, 2011, vol. 59, # 1, p. 96 - 99
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) manufacturers
- Product
- 1H-Isoindol-1-one, 2,3-dihydro-5-hydroxy- (9CI) 252061-66-8
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2019-12-20