4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
- Product Name
- 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 71149-52-5
- Chemical Name
- 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- -7H-pyrroL;4-Chloro-2-methyl-7H-pyr;4-Chloro-2-methyl-7H-pyrrolo;2-methyl-4-chloro-pyrrolopyrimidine;4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine;4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine;1H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-2-methyl-;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-2-methyl-;4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 98%
- CBNumber
- CB71094100
- Molecular Formula
- C7H6ClN3
- Formula Weight
- 167.6
- MOL File
- 71149-52-5.mol
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Property
- Melting point:
- 207-208 °C
- Boiling point:
- 290.5±50.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 11.49±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JRD0183
- Product name
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $783
- Updated
- 2025/07/31
- Product number
- C368283
- Product name
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 073310
- Product name
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FC139697
- Product name
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC139697
- Product name
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
89792-11-0
71149-52-5
General procedure for the synthesis of 4-chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine using 2-methyl-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one as starting material: 90 mg (0.60 mmol) of hydroxypyrrolo[pyrimidin-4(7H)-one was suspended in 2 mL of phosphorochloridic acid chloride, and the reaction was heated and refluxed for 2 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation under reduced pressure. The residue was carefully quenched with an ice water bath and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography (eluent: 10% methanol/dichloromethane) to afford the target compound 4-chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine as a colorless solid (86 mg, 85% yield). Mass spectrometry result: (M + H)+ m/z = 168.
References
[1] Patent: WO2009/9740, 2009, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 36
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Suppliers
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View Lastest Price from 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine manufacturers
- Product
- 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine 71149-52-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 71149-52-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 71149-52-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08