ChemicalBook > CAS DataBase List > 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine

4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine

Product Name
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
CAS No.
71149-52-5
Chemical Name
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
Synonyms
-7H-pyrroL;4-Chloro-2-methyl-7H-pyr;4-Chloro-2-methyl-7H-pyrrolo;2-methyl-4-chloro-pyrrolopyrimidine;4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine;4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine;1H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-2-methyl-;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-2-methyl-;4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 98%
CBNumber
CB71094100
Molecular Formula
C7H6ClN3
Formula Weight
167.6
MOL File
71149-52-5.mol
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4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Property

Melting point:
207-208 °C
Boiling point:
290.5±50.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
11.49±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

Risk Statements 
36
Safety Statements 
26
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
JRD0183
Product name
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity
Aldrich
Packaging
1g
Price
$783
Updated
2025/07/31
TRC
Product number
C368283
Product name
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
073310
Product name
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC139697
Product name
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC139697
Product name
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging
250mg
Price
$75
Updated
2021/12/16
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4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

89792-11-0

71149-52-5

General procedure for the synthesis of 4-chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine using 2-methyl-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one as starting material: 90 mg (0.60 mmol) of hydroxypyrrolo[pyrimidin-4(7H)-one was suspended in 2 mL of phosphorochloridic acid chloride, and the reaction was heated and refluxed for 2 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation under reduced pressure. The residue was carefully quenched with an ice water bath and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography (eluent: 10% methanol/dichloromethane) to afford the target compound 4-chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine as a colorless solid (86 mg, 85% yield). Mass spectrometry result: (M + H)+ m/z = 168.

References

[1] Patent: WO2009/9740, 2009, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 36

4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Suppliers

China 110 India 5 United Kingdom 3 United States 10 Global 128
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View Lastest Price from 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine 71149-52-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 71149-52-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 71149-52-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

71149-52-5, 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidineRelated Search:

Pyrimidine Tribenuron methyl Methyl salicylate N-Methyl-2-pyrrolidone 1-Methylpyrrolidine Methylparaben Methyl acrylate Methanol Kresoxim-methyl Methyl METHYL-2-PYRROLIDONE Difluorochloromethane 4-CHLORO-7-MESITYL-2,5,6-TRIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDINE Ethyl 4-chloropyrrolo[2,3-d]pyrimidine-2-carboxylate 4-CHLORO-2,5-DIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-2-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDINE 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine 4-CHLORO-2-METHYL-9-(5-METHYLPYRIDIN-2-YL)-9H-PYRIMIDO[4,5-B]INDOLE

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  • 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
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  • 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 98%
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  • 71149-52-5
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