2,6-Dioxopiperidine-3-ammonium chloride

Description

Product Name: 2,6-Dioxopiperidine-3-ammonium chloride
CAS No.: 24666-56-6
Chemical Name: 2,6-Dioxopiperidine-3-ammonium chloride
Synonyms: 3-Amino-2,6-piperidinedione hydrochloride;2,6-dioxopiperidin-3-aminium chloride;RSYY（Avanafil)-31;Pomalidomide Impurity 6;Lenalidomide/Pomadoamine;Lenalidomide EP Impurity-A;Lenalidomide Impurity 6 HCl;Lenalidomide Impurity 9 HCl;Lenalidomide Impurity 2 HCl;2,6-Dioxopiperidine-3-ammonium
CBNumber: CB71113128
Molecular Formula: C5H9ClN2O2
Formula Weight: 164.59016
MOL File: 24666-56-6.mol

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2,6-Dioxopiperidine-3-ammonium chloride Property

Melting point:: 120 °C (approx)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Sparingly, Sonicated)
form: powder
color: White
InChI: InChI=1S/C5H8N2O2.ClH/c6-3-1-2-4(8)7-5(3)9;/h3H,1-2,6H2,(H,7,8,9);1H
InChIKey: YCPULGHBTPQLRH-UHFFFAOYSA-N
SMILES: C1CC(N)C(=O)NC1=O.Cl

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Safety

Risk Statements: 20/21/22
Safety Statements: 3/9-36/37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2691
Product name: 3-Amino-2,6-piperidinedione Hydrochloride
Packaging: 5G
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: A2691
Product name: 3-Amino-2,6-piperidinedione Hydrochloride
Packaging: 25G
Price: $141
Updated: 2025/07/31

TRC

Product number: A632980
Product name: 3-Aminopiperidine-2,6-dioneHydrochloride
Packaging: 5g
Price: $95
Updated: 2021/12/16

TRC

Product number: A632980
Product name: 3-Aminopiperidine-2,6-dioneHydrochloride
Packaging: 25g
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 075215
Product name: 3-Aminopiperidine-2,6-dione hydrochloride
Purity: 95+%
Packaging: 1g
Price: $19
Updated: 2021/12/16

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2,6-Dioxopiperidine-3-ammonium chloride Chemical Properties,Usage,Production

Description

2,6-Dioxopiperidine-3-ammonium chloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del (5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation. Moreover, it is also a metabolite of thalidomide (T338850) that inhibits FGF-induced angiogenesis.

Chemical Properties

White crystal

Uses

2,6-Dioxopiperidine-3-ammonium chloride can be used as an important intermediate of antineoplastic drug lenalidomide.

Synthesis

24666-55-5

24666-56-6

General procedure for the synthesis of 3-aminopiperidine-2,6-dione hydrochloride from benzyl (2,6-dioxopiperidin-3-yl)carbamate: Benzyl (2,6-dioxopiperidin-3-yl)carbamate (4.00 g, 15.0 mmol) was dissolved in methanol (200 mL) and 2N HCl solution (15 mL) was added. Subsequently, 5% Pd-C catalyst (100 mg) was added and the hydrogenation reaction was carried out at 60 psi hydrogen pressure for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness to afford 3-aminopiperidine-2,6-dione hydrochloride as a white solid (2.61 g, 100% yield) with a melting point of 245 °C (decomposition, ignition temperature 235 °C).1H NMR (400 MHz, DMSO-D6) δ ppm: 11.22 (br s, 1H), 8.68 (br s, 3H), 4.20 (dd, J = 13.0, 5.3 Hz, 1H), 2.77-2.65 (m, 1H), 2.64-2.56 (m, 1H), 2.27-2.19 (m, 1H), 2.09-1.97 (m, 1H).

References

[1] Patent: WO2008/7979, 2008, A1. Location in patent: Page/Page column 13
[2] Patent: CN108218833, 2018, A. Location in patent: Paragraph 0043; 0044; 0057; 0058; 0063; 0071; 0072
[3] Patent: WO2018/154516, 2018, A1. Location in patent: Page/Page column 7-8
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 11, p. 1625 - 1630

2,6-Dioxopiperidine-3-ammonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dioxopiperidine-3-ammonium chloride Suppliers

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View Lastest Price from 2,6-Dioxopiperidine-3-ammonium chloride manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 3-aminopiperidine-2,6-dione hydrochloride 24666-56-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

Shaanxi Xianhe Biotech Co., Ltd

Product: 3-Amino-2,6-piperidinedione hydrochloride 24666-56-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

Henan Aochuang Chemical Co.,Ltd.

Product: 2,6-Dioxopiperidine-3-ammonium chloride 24666-56-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

24666-56-6, 2,6-Dioxopiperidine-3-ammonium chlorideRelated Search:

Methyl 2-(chloromethyl)-3-nitrobenzoate 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinecarboxylic acid ethyl ester N-Acetyl Lenalidomide cis-1,2,3,6-Tetrahydrophthalic anhydride Argatroban Bumetanide Citalopram Methyl 2-bromomethyl-5-nitrobenzoate Lenalidomide Impurity 13 Lenalidomide Impurity 11 (3R,5R)-3-(Boc-amino)-5-methylpiperidine Lenalidomide Impurity 3 tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate Lenalidomide Impurity 14 Lenalidomide Impurity 12 Lenalidomide Impurity 7 Lenalidomide Impurity (2) Lenalidomide Glucosides

2,6-Dioxopiperidine-3-ammonium chloride

2,6-Dioxopiperidine-3-ammonium

Lenalidomide Impurity 6 HCl

Pomalidomide/lenalidomide INT II

3-Amino-piperidine-2,6-dione [2353-44-8] at 262 USD, please be noted, what we provide is HCl salt form

2,6-dioxopiperidin-3-aminium chloride

Pomalidomide Impurity 6

6-piperidinedione hydrochloride

2-Amino-glutarimide Hydrochloride

3-Aminopiperidine-2,6-dione Monohydrochloride

DL-Glutamic Acid Imide Hydrochloride

2,6-Piperidinedione, 3-amino-, hydrochloride

Glutamic acid imide hydrochloride

3-Amino-2,6-dioxo-piperidine hydrochloride ,99%

3-AMino-2,6-Piperidinedione HCl

3-AMino-2,6-dioxo-piperidine hydrochloride

2,6-Piperidinedione,3-aMino-, hydrochloride (1:1)

3-amino piperdine-2,6-dion hydrochloride

3-Amino-2,6-piperidinedione hydrochloride

2,6-Dioxopiperidine-3-ammonium chloride###3-aminopiperidine-2,6-dione hydrochloride

3-Aminopiperidine-2,6-dione hydrochL

(+-)-3-Amino-2,6-piperidinedione monohydrochloride

2,6-Dioxopiperidine-3-ammonium chloride ISO 9001：2015 REACH

6-Dioxopiperidine-3-ammonium chloride

(2,6-dioxopiperidin-3-yl)azanium

Lenalidomide/Pomadoamine

RSYY（Avanafil)-31

3-amino-2,6-Piperidinedione hydrochloride (1:1)

3-Aminopiperidine-2,6-dione hydrochloride (3AP)

rac-α-aminoglutarimide hydrochloride

Lenalidomide EP Impurity-A

Lenalidomide Impurity 9 HCl

Lenalidomide Impurity 26(Hydrochloride)

3-Aminopiperidine-2,6-dione hydrochloride salt

Lenalidomide Impurity 2 HCl

24666-56-6

C5H8N2O2ClH

Pyrrolidines

24666-56-6