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NU6140

Product Name
NU6140
CAS No.
444723-13-1
Chemical Name
NU6140
Synonyms
NU6140;NU6140, 10 mM in DMSO;4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide;4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide;Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-;CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
CBNumber
CB71114327
Molecular Formula
C23H30N6O2
Formula Weight
422.52
MOL File
444723-13-1.mol
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NU6140 Property

Boiling point:
707.8±70.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form 
White to off-white solid.
pka
9.41±0.10(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1323
Product name
NU6140
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1323
Product name
NU6140
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$467
Updated
2025/07/31
Cayman Chemical
Product number
17271
Product name
NU 6140
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17271
Product name
NU 6140
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
17271
Product name
NU 6140
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
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NU6140 Chemical Properties,Usage,Production

Uses

NU 6140 is a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.

Biological Activity

NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.', 'NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.

IC 50

cdk2-cyclin A: 0.41 μM (IC50); CDK1-Cyclin B: 6.6 μM (IC50); CDK4-Cyclin D: 5.5 μM (IC50); cdk5-p25: 15 μM (IC50); cdk7-cyclin H: 3.9 μM (IC50); Aurora A: 67 nM (IC50); Aurora B: 35 nM (IC50)

storage

Desiccate at +4°C

NU6140 Preparation Products And Raw materials

Raw materials

Preparation Products

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NU6140 Suppliers

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444723-13-1, NU6140Related Search:

Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II AMINOPURVALANOL A SU 9516 NU6102 OLOMOUCINE

  • NU6140
  • 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
  • 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
  • Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-
  • CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
  • NU6140, 10 mM in DMSO
  • 444723-13-1