ChemicalBook > CAS DataBase List > 2-Methylthiophenylboronic acid

2-Methylthiophenylboronic acid

Product Name
2-Methylthiophenylboronic acid
CAS No.
168618-42-6
Chemical Name
2-Methylthiophenylboronic acid
Synonyms
3-BORONOTHIOANISOLE;2-BORONOTHIOANISOLE;RARECHEM AH PB 0143;RARECHEM AH PB 0144;2-Methylthiophenylbo;2-Methylthiophenylboronic;2-THIOANISOLEBORONIC ACID;2-thioanisolephenylborate;THIOANISOLE-2-BORONIC ACID;THIOANISOLE-3-BORONIC ACID
CBNumber
CB7116432
Molecular Formula
C7H9BO2S
Formula Weight
168.02
MOL File
168618-42-6.mol
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2-Methylthiophenylboronic acid Property

Melting point:
77-83 °C (lit.)
Boiling point:
215C
Density 
1,087g/cm
refractive index 
1,423-1,425
storage temp. 
Inert atmosphere,2-8°C
Water Solubility 
Slightly soluble in water
form 
Crystalline Powder
pka
8.50±0.58(Predicted)
color 
White
BRN 
8309529
InChI
InChI=1S/C7H9BO2S/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5,9-10H,1H3
InChIKey
QXBWTYBCNFKURT-UHFFFAOYSA-N
SMILES
B(C1=CC=CC=C1SC)(O)O
CAS DataBase Reference
168618-42-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-36-7/9-37/39-22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
521248
Product name
2-(Methylthio)phenylboronic acid
Packaging
10g
Price
$92.7
Updated
2025/07/31
TCI Chemical
Product number
M1570
Product name
2-(Methylthio)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
M1570
Product name
2-(Methylthio)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$180
Updated
2025/07/31
TRC
Product number
M218800
Product name
2-(Methylthio)phenylboronic acid
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J91260
Product name
2-(Methylthio)phenylboronic acid
Packaging
1g
Price
$15
Updated
2021/12/16
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2-Methylthiophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powde

Uses

suzuki reaction

Uses

Reactant for:

  • Palladium-catalyzed cross-coupling reactions
  • Suzuki-Miyaura coupling reactions

Synthesis

5419-55-6

19614-16-5

168618-42-6

Part A: Preparation of 2-methylthiophenylboronic acid. 2-Bromothioanisole (29.0 g, 143 mmol) was dissolved in anhydrous tetrahydrofuran (400 mL) and the solution was cooled to -75°C. n-Butyllithium (62.0 mL, 2.5 M hexane solution, 155 mmol) was added slowly over 50 minutes. After stirring for 25 min, triisopropyl borate (46 mL, 199 mmol) was added dropwise over 35 min. The cold bath was removed and the reaction mixture was stirred at room temperature for 16 hours. The resulting solution was cooled in an ice bath and 6 M hydrochloric acid (100 mL) was added. The mixture was stirred at room temperature for 5 hours and then concentrated to half the original volume. The concentrate was partitioned between ether and water. The organic layer was extracted with 2 M sodium hydroxide solution, subsequently acidified with 6 M hydrochloric acid, concentrated again, and extracted several times with ether. The ether extracts were combined, dried with sodium sulfate, filtered and the solvent evaporated to give a beige solid product (20.4 g, 85% yield).1H-NMR (CDCl3) δ: 8.01 (dd, 1H, J = 7.3, J' = 1.4), 7.53 (dd, 1H, J = 7.7, J' = 1.1), 7.43 (td, 1H, J = 7.3, J' = 1.8), 7.34 (td, 1H, J = 7.3, J'= 1.5), 6.22 (s, 2H), 2.50 (s, 3H).

References

[1] Patent: EP946508, 2009, B1. Location in patent: Page/Page column 60
[2] Patent: EP1491187, 2004, A1. Location in patent: Page 26

2-Methylthiophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methylthiophenylboronic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Methylthiophenylboronic acid 168618-42-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-27
Hebei Xinsheng New Material Technology Co., LTD.
Product
2-Methylthiophenylboronic acid 168618-42-6
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 Ton
Release date
2023-10-31
Hebei Xinsheng New Material Technology Co., LTD.
Product
2-Methylthiophenylboronic acid 168618-42-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
30000 Kg
Release date
2023-11-15

168618-42-6, 2-Methylthiophenylboronic acidRelated Search:

ISOMETHIOZIN Phenylboronic acid Albendazole 4-Methylsulphonyl benzaldehyde Ethyl 2-(Chlorosulfonyl)acetate Febantel Phenyl isothiocyanate 4-(Trifluoromethylthio)phenol 4-Tolylboronic acid Folic acid Citric acid Ascoric Acid THIANTHRENE-1-BORONIC ACID 2-(Methanesulfonyl)phenylboronic acid 2-(METHYLSULFINYL)PHENYLBORONIC ACID 2-ETHYLTHIOPHENYLBORONIC ACID 2-ETHYLSULFINYLPHENYLBORONIC ACID 2-ETHYLSULFONYLPHENYLBORONIC ACID

  • 2-Methylthiophenylbo
  • 2-THIOANISOLEBORONIC ACID; (2-THIOMETHYLPHENYL)BORONIC ACID
  • Methylthio)phenylboronic ac
  • (contains varying aMounts of Anhydride)
  • 2-(Methylthio)phenylboronic Acid&nbsp
  • B-[2-(methylthio)phenyl]boronic acid
  • (2-METHYLSULFANYL-PHENYL)-BORONIC ACID
  • 2-(METHYLTHIO)PHENYLBORONIC ACID
  • 2-(METHYLTHIO)BENZENEBORONIC ACID
  • (3-THIOMETHYLPHENYL)BORONIC ACID
  • 3-(METHYLTHIO)BENZENEBORONIC ACID
  • 3-(METHTHIO)PHENYLBORONIC ACID
  • 3-BORONOTHIOANISOLE
  • 2-(Methylthio)phenylboronic acid~2-Thioanisoleboronic acid
  • 2-Methylthiopenylboronic Acid
  • 2-Methylthiophenylboronic
  • 2-(METHYLMERCAPTO)-PHENYLBORONIC ACID
  • Boronic acid, [2-(methylthio)phenyl]-
  • 2-(METHYLTHIO)BENZENEBORONIC ACID, 98+%
  • 2-(Methylthio)phenylboronic Acid (contains varying amounts of Anhydride)
  • 2-BORONOTHIOANISOLE
  • 2-THIOANISOLEBORONIC ACID
  • (2-THIOMETHYLPHENYL)BORONIC ACID
  • 2-(Methylthio)phenylboronic acid ,98%
  • M-(METHYLTHIO)PHENYLBORONIC ACID
  • O-(METHYLTHIO)PHENYLBORONIC ACID
  • RARECHEM AH PB 0143
  • RARECHEM AH PB 0144
  • THIOANISOLE-2-BORONIC ACID
  • THIOANISOLE-3-BORONIC ACID
  • 2-thioanisolephenylborate
  • Boronic acid, B-[2-(methylthio)phenyl]-
  • 2-Methylthiophenylboronicaci
  • 2-Thioansole Phenyl Boronic Acid
  • 2-(Methylthio)phenylboronic acid - [M4620]
  • 168618-42-6
  • 168618-48-6
  • 128317-11-8
  • C7H11IN2OSi
  • C7H9O2BS
  • CH3SC6H4BOH2
  • C7H9BO2S
  • C13H19O2BS
  • Organometallic Reagents
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Aryl
  • BORONIC ACID
  • Boronate Ester
  • Potassium Trifluoroborate
  • Aryl
  • Organoborons
  • Boronic Acids
  • Boronic Acids and Derivatives
  • B (Classes of Boron Compounds)
  • Boronic acids
  • Boronic Acid
  • blocks