NOCARDAMINE
- Product Name
- NOCARDAMINE
- CAS No.
- 26605-16-3
- Chemical Name
- NOCARDAMINE
- Synonyms
- Nocardamin;NOCARDAMINE;deferrioxamine E;PROFERRIOXAMIN E;Desferrioxamine E;Desferri-ferrioxamine E;Nocardamine (Deferrioxamine E);1,12,23-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone;6,17,28-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexaone;1,6,12,17,23,28-Hexaazacyclotritriacontane-2,5,13,16,24,27-hexone, 1,12,23-trihydroxy-
- CBNumber
- CB7117055
- Molecular Formula
- C27H48N6O9
- Formula Weight
- 600.7
- MOL File
- 26605-16-3.mol
NOCARDAMINE Property
- Melting point:
- 192-195°
- Density
- 1.162±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (5 mg/ml)
- form
- solid
- pka
- 8?+-.0.20(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 28745
- Product name
- Nocardamine
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- N634083
- Product name
- Nocardamine
- Packaging
- 1mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 1037CB
- Product name
- Nocardamine
- Packaging
- 1mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- AG-CN2-0150-M005
- Product name
- Nocardamine
- Purity
- ≥95%(HPLC)
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- API0019192
- Product name
- NOCARDAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $515.55
- Updated
- 2021/12/16
NOCARDAMINE Chemical Properties,Usage,Production
Description
Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 μM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.
Uses
Nocardamine is a cyclic siderophore.
Definition
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.
storage
+4°C
References
Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741 Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34 Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49 Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654 Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
NOCARDAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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