Bipenquinate
- Product Name
- Bipenquinate
- CAS No.
- 96201-88-6
- Chemical Name
- Bipenquinate
- Synonyms
- CS-340;Dup-785;NSC-368390;Bipenquinate;Brequinar sodium;Brequinar sodium (DuP-785;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylate;SODIUM 6-FLUORO-2-(2-FLUORO-[1,1-BIPHENYL]-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLATE;Sodium 6-fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylate;6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
- CBNumber
- CB71178121
- Molecular Formula
- C23H14F2NNaO2
- Formula Weight
- 0
- MOL File
- 96201-88-6.mol
Bipenquinate Property
- Melting point:
- >360°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 15 mg/ml with warming)
- form
- solid
- color
- Off-white or white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6196
- Product name
- Brequinarsodium
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 6196
- Product name
- Brequinarsodium
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $436
- Updated
- 2021/12/16
- Product number
- B677455
- Product name
- BrequinarSodium
- Packaging
- 10mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- INB0005314
- Product name
- BREQUINAR SODIUM
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- INB0005314
- Product name
- BREQUINAR SODIUM
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $4209.98
- Updated
- 2021/12/16
Bipenquinate Chemical Properties,Usage,Production
Description
Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2?with IC50’s between 0.2 and 5.8 μM in various cell lines3?and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4?Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5-7
Uses
Antineoplastic.
Definition
ChEBI: Brequinar sodium is an organic sodium salt of brequinar. It has a role as an anticoronaviral agent, an antineoplastic agent, an antiviral agent, an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an antimetabolite. It contains a brequinar(1-).
storage
Store at +4°C
References
1) Chen?et al.?(1986)?Mechanism of action of the novel anticancer agent 6-fluoro-2-(2’-fluoro-1,1’-biohenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis;?Cancer Res.,?46?5014 2) Peters?et al.?(1990)?In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic aicd dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients;?Cancer Res.,?50?4644 3) De Kant?et al.?(1989) The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium; Cancer Lett.,?46?123 4) Sykes?et al.?(2016)?Inhibition of Dihydroorotate Overcomes Differentiation Blockade in Acute Myeloid Leukemia;?Cell,?167?171 5) Qing?et al. (2010)?Characterization of Dengue Virus Resistance to Brequinar in Cell Culture;?Antimicrob. Agents Chemother.,?54?3686 6) Andersen?et al.?(2019)?Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine;?Viruses,?11?E964 7) Park?et al.?(2020)?Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses;?J. Virol.,?94?e02149
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