Pexiganan

Product Name: Pexiganan
CAS No.: 147664-63-9
Chemical Name: Pexiganan
Synonyms: Pexiganan Acetate;Pexiganan USP/EP/BP;L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-
CBNumber: CB71179476
Molecular Formula: C122H210N32O22
Formula Weight: 2477.17
MOL File: 147664-63-9.mol

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Pexiganan Property

Boiling point:: 2261.8±65.0 °C(Predicted)
Density: 1.180±0.06 g/cm3(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Pexiganan Chemical Properties,Usage,Production

Uses

Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].

Synthesis

Pexiganan is synthesized using a combination of liquid-phase and solid-phase methods. Step 1: The dipeptide fragment Fmoc-Lys(Boc)-Lys(Boc)-OH is synthesized via liquid-phase method. Specifically, Fmoc-Lys(Boc)-OH is activated with HOSu and DCC to form the active ester, which then reacts with H-Lys(Boc)-OH. Step 2: Solid-phase synthesis is employed. Starting with an amino resin, N-terminal Fmoc-protected and side-chain protected amino acids are coupled sequentially according to the pexiganan backbone sequence. The lysine residues at positions 7&8, 10&11, and 21&22 are coupled using the dipeptide fragment prepared in step 1 to simplify the synthesis. Step 3: The peptide resin is cleaved with a cleavage cocktail. The resulting crude peptide is purified and lyophilized to obtain the final pexiganan product.

in vivo

Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse^[3].
Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock^[4].

Animal Model:	H. pylori-infected mouse^[3].
Dosage:	1, 3, 10 or 30 mg/kg
Administration:	Oral administration, daily for three consecutive days.
Result:	Lowered H. pylori urease activities in mouse stomachs.

Animal Model:	Rat models of Gram-negative septic shock (induced by E.coli ATCC 25922)^[4].
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Displayed antimicrobial activities and survival rates of 67.7%.

References

[1] Lamb HM, et al. Pexiganan acetate. Drugs. 1998 Dec;56(6):1047-52; discussion 1053-4. DOI:10.2165/00003495-199856060-00011
[2] Ge Y, et al. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43(4):782-8. DOI:10.1128/AAC.43.4.782
[3] Zhang XL, et al. The synthetic antimicrobial peptide pexiganan and its nanoparticles (PNPs) exhibit the anti-helicobacter pylori activity in vitro and in vivo. Molecules. 2015 Mar 2;20(3):3972-85. DOI:10.3390/molecules20033972
[4] Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005 Feb;26(2):207-16. DOI:10.1016/j.peptides.2004.09.012

Pexiganan Preparation Products And Raw materials

Raw materials

Preparation Products

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Pexiganan Suppliers

China 42 United States 2 Global 44

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
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Avantpbc Chemical Tech(Shanghai) Co,Ltd.

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Nanjing Leon Biological Technology Co., Ltd.

Tel: 025-84523390 -127; 17705183659
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Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
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Email: zhao.xu@njpeptide.com
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Chengdu Youngshe Chemical Co., Ltd.

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Email: Caroline@youngshechem.com
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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Zhejiang J&C Biological Technology Co.,Limited

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AFINE CHEMICALS LIMITED

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Shaanxi Dideu Medichem Co. Ltd

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147664-63-9, PexigananRelated Search:

PalMitoyl Tripeptide-1 PALMITOYL OLIGOPEPTIDE Abaloparatide Etelcalcetide Acetyl Hexapeptide-1 GLUCAGON (1-37) (PORCINE) N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine omiganan pentahydrochloride ACETYL PENTAPEPTIDE-1 Pexiganan

Pexiganan Acetate

L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan USP/EP/BP

147664-63-9

C122H210N32O22