ChemicalBook > CAS DataBase List > 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE

2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE

Product Name: 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE
CAS No.: 195053-92-0
Chemical Name: 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE
Synonyms: 4-(2-Aminoethyl)-1-tritylimidazole;2-(1-tritylimidazol-4-yl)ethanamine;2-(1-Trityl-1H-iMidazol-4-yl)ethanaMine;2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE;N'-(3,4-dichlorophenyl)propane-1,5-diamine;2-(1-trityl-1H-imidazol-4-yl)ethan-1-amine;1-(Triphenylmethyl)-1H-Imidazole-4-ethanamine;1H-Imidazole-4-ethanamine, 1-(triphenylmethyl)-;2-(1-Trityl-1H-iMidazol-4-yl)ethanaMine hydrate;2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE
CBNumber: CB7119428
Molecular Formula: C24H23N3
Formula Weight: 353.46
MOL File: 195053-92-0.mol

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2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Off-white to light yellow Solid

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Safety

RIDADR: 3259
HazardClass: 8
PackingGroup: Ⅲ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0018561
Product name: 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $909.56
Updated: 2021/12/16

AK Scientific

Product number: 1017AJ
Product name: 2-(1-Trityl-1H-imidazol-4-yl)-ethylaminehydrate
Packaging: 5g
Price: $1072
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018561
Product name: 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE
Purity: 95.00%
Packaging: 5G
Price: $1485.62
Updated: 2021/12/16

Chemenu

Product number: CM117874
Product name: 4-(2-Aminoethyl)-1-tritylimidazole
Purity: 95+%
Packaging: 250mg
Price: $52
Updated: 2021/12/16

Crysdot

Product number: CD11174404
Product name: 2-(1-Trityl-1H-imidazol-4-yl)ethanamine
Purity: 97%
Packaging: 250mg
Price: $64
Updated: 2021/12/16

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2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE Chemical Properties,Usage,Production

Synthesis

312937-01-2

195053-92-0

Histamine dihydrochloride (20.47 g, 0.111 mol) was used as starting material and stirred with triethylamine (48 mL, 0.345 mol) in anhydrous methanol (400 mL) for 10 min at room temperature. Subsequently, a solution of ethyl trifluoroacetate (14.6 mL, 0.122 mol) in methanol (30 mL) was added slowly and dropwise over a period of 30 min at 0 °C. The reaction mixture was continued to be stirred at room temperature for 3.5 hours before the solvent was removed by vacuum evaporation. The residue was dissolved in dichloromethane (450 mL) and triethylamine (31 mL, 0.222 mol) was added. Next, triphenylmethyl chloride (34.1 g, 0.122 mol) was added in batches and the mixture was stirred overnight at room temperature. Upon completion of the reaction, chloroform (400 mL) and water (600 mL) were added to the mixture, the aqueous layer was separated and extracted with chloroform (3 x 400 mL). The organic layers were combined and dried with anhydrous magnesium sulfate. After evaporation of the solvent, the resulting beige solid was ground with hexane (1000 mL) and filtered to afford 2,2,2-trifluoro-N-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-acetamide as a white solid in a yield of 45.54 g (91% yield).1H NMR (300 MHz, CDCl3, δH): 8.44 (bs, 1H) , 7.43 (s, 1H), 7.41-7.33 (m, 9H), 7.19-7.10 (m, 6H), 6.65 (s, 1H), 3.66 (q, J = 5.9 Hz, 2H), 2.79 (t, J = 5.9 Hz, 2H). The above amide (45.54 g, 0.101 mol) was dissolved in tetrahydrofuran (1000 mL) and methanol (1200 mL) and a solution of sodium hydroxide (20.26 g, 0.507 mol) in water (500 mL) was added. The mixture was stirred at room temperature for 2 hours and then concentrated. The residue was partitioned between chloroform (1200 mL) and water (800 mL) and the aqueous layer was extracted with chloroform (3 x 400 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and the solvent was evaporated to give a brown oil, which was dried for 3 days to give the title product 2-(1-trityl-1H-imidazol-4-yl)ethylamine as a beige solid in a yield of 32.23 g (90% yield), 82% total yield. Melting point: 111-113 °C. 1H NMR (300 MHz, CDCl3, δH): 7.39 (d, J = 1.3 Hz, 1H), 7.38-7.32 (m, 9H), 7.20-7.12 (m, 6H), 6.61 (s, 1H), 3.00 (t, J = 6.6 Hz, 2H), 2.70 (t, J = 6.5 Hz , 2H), 1.93 (bs, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 9, p. 1269 - 1273
[2] Patent: EP3000482, 2016, A1. Location in patent: Paragraph 0261; 0263
[3] Patent: US2010/216854, 2010, A1. Location in patent: Page/Page column 24
[4] Patent: US6562823, 2003, B1
[5] Journal of Biological Inorganic Chemistry, 2016, vol. 21, # 5-6, p. 777 - 792

2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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195053-92-0, 2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATERelated Search:

N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester H-His(Trt)-OH Boc-His(Trt)-OH 3,5-DIIODO-D-TYROSINE HYDROCHLORIDE FMOC-D-HIS(MTT)-OH N-Fmoc-N'-trityl-D-histidine Fmoc-His(Trt)-OH D-HISTIDINE(1-TRT)-OME HCL H-His(Trt)-OMe · HCl AC-HIS(1-TRT)-OH N-α-Fmoc-N-im-trityl-L-histidine N-carboxyanhydride TRT-HIS(TRT)-OH H-HIS(1-TRT)-OTBU FMOC-HIS(MTT)-OH N-im-Trityl-D-histidine FMOC-D-HIS(1-TRT)-SASRIN(TM)-RESIN FMOC-HIS(TRT)-WANG RESIN FMOC-HIS(MMT)-OH

2-(1-Trityl-1H-iMidazol-4-yl)ethanaMine hydrate

2-(1-Trityl-1H-iMidazol-4-yl)ethanaMine

1H-Imidazole-4-ethanamine, 1-(triphenylmethyl)-

1-(Triphenylmethyl)-1H-Imidazole-4-ethanamine

2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE

2-(1-TRITYL-1H-IMIDAZOL-4-YL)-ETHYLAMINE HYDRATE

2-(1-tritylimidazol-4-yl)ethanamine

2-(1-trityl-1H-imidazol-4-yl)ethan-1-amine

N'-(3,4-dichlorophenyl)propane-1,5-diamine

4-(2-Aminoethyl)-1-tritylimidazole

2-(1-Trityl-1H-imidazol-4-yl)-ethylamine, CAS 195053-92-0

195053-92-0

C24H23N3

C24H23N3H2O