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Fmoc-His(Trt)-OH

Product Name
Fmoc-His(Trt)-OH
CAS No.
109425-51-6
Chemical Name
Fmoc-His(Trt)-OH
Synonyms
FMOC-HIS(TRT)-OH;FMOC-HIS(TRT);FMOC-L-HIS(TRT)-OH;Fomc-His(Trt)-OH;FMOC-HIS(TRITYL)-OH;N-FMOC-N-TRITYL-L-HISTIDINE;CAS:109425-51-6;Fmoc-L-His(Trt);N-Fmoc-N'-trityL;Fmoc-His(Trt)-0H
CBNumber
CB8444769
Molecular Formula
C40H33N3O4
Formula Weight
619.71
MOL File
109425-51-6.mol
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Fmoc-His(Trt)-OH Property

Melting point:
150-155 °C(lit.)
alpha 
+86.0 °(D/25)(c=5%inCHCl3)
Boiling point:
811.7±65.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
refractive index 
97 ° (C=5, CHCl3)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
3.06±0.10(Predicted)
color 
White to off-white
optical activity
[α]/D 87±5°, c = 1 in chloroform
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
BRN 
5204720
Major Application
peptide synthesis
InChIKey
XXMYDXUIZKNHDT-QNGWXLTQSA-N
SMILES
OC(=O)[C@H](Cc1cn(cn1)C(c2ccccc2)(c3ccccc3)c4ccccc4)NC(=O)OCC5c6ccccc6-c7ccccc57
CAS DataBase Reference
109425-51-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-24/25
WGK Germany 
3
F 
10-21
HS Code 
2933 29 90
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52032
Product name
Fmoc-His(Trt)-OH
Purity
Novabiochem?
Packaging
25g
Price
$74.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52032
Product name
Fmoc-His(Trt)-OH
Purity
Novabiochem?
Packaging
100g
Price
$188
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52032
Product name
Fmoc-His(Trt)-OH
Purity
Novabiochem?
Packaging
250g
Price
$375
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52032
Product name
Fmoc-His(Trt)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$718
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52032
Product name
Fmoc-His(Trt)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$718
Updated
2025/07/31
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Fmoc-His(Trt)-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid powder, soluble in water but poorly soluble in ethanol and insoluble in ether. Its structure contains a unique imidazole unit. The imidazole group can form a coordination compound with Fe2+ or other metal ions to promote the absorption of iron, so it can be used to prevent and treat anemia.

Uses

Fmoc-His(Trt)-OH is used in the synthesis and application of Fmoc-His(3-Bum)-OH.

General Description

Fmoc-His(Trt)-OH has fmoc group to protect -αNH2, it can be used as a building block in solid-phase peptide synthesis (SPPS).

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

In a dry reaction flask, N-deprotected amino acids were dissolved in 0.15 M sodium carbonate (2~3 equiv.), and then an acetone solution ( 0.1 M) of 9-fluorenylmethyl-N-succinimidyl carbonate (1~1.2 equiv.) was added to the above reaction mixture. Water was added to the reaction system to adjust the pH of the reaction system to 9~10. The resulting reaction mixture was stirred at room temperature for 4 h. At the end of the reaction, the resulting reaction mixture was concentrated at 30 ??C under reduced pressure to remove the acetone, and the resulting residue was diluted with H2O and the pH of the solution was adjusted to 9~10 with sodium carbonate 0.6 M. The resultant solution was extracted twice with ether. The pH of the aqueous phase was adjusted to 4-5 by slowly adding 10 % citric acid to the resulting organic solution, the organic layer was separated and dried with anhydrous sodium sulfate, the desiccant was removed by filtration and the resulting filtrate was concentrated under vacuum, and the resulting crude product was purified by silica gel column chromatography to obtain the molecules of N-Fmoc-N'-trityl-L-histidine.

Fmoc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-His(Trt)-OH Suppliers

Americas 1 Belgium 1 Canada 3 China 412 Europe 5 France 3 Germany 7 Hungary 2 India 13 Italy 2 Japan 7 Poland 1 South Korea 1 Switzerland 6 United Kingdom 15 United States 62 Global 541
Chengdu Tachem Co., Ltd
Tel
19983060238
Email
sales@tachem.cn
Country
China
ProdList
103
Advantage
58
Gill polypeptide biopharmaceutical (dalian) co., LTD
Tel
021-61263455 13167021076
Email
amy@glschina.com
Country
China
ProdList
9920
Advantage
58
Lanxi Xingnuo Import and Export Trading Co., Ltd
Tel
0579-8831088 15888978871
Email
994350525@qq.com
Country
China
ProdList
23
Advantage
58
Lianhe Aigen Pharmatech Co.,Ltd.
Tel
18918657159
Email
sales-Aigen@lianhetech.com
Country
China
ProdList
3000
Advantage
58
Nantong Enwang New Materials Co.,Ltd
Tel
18912257866
Email
739904460@qq.com
Country
China
ProdList
56
Advantage
58
GenChem & GenPharm (Changzhou) Co., Ltd.
Tel
0519-85720003 18861157602
Fax
0519-85720007
Email
410649415@qq.com
Country
China
ProdList
111
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58
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD
Tel
0838-2809458 13350585791
Email
pharm@biots.cn
Country
China
ProdList
620
Advantage
58
Wuhan Grand Hoyo Co., Ltd.
Tel
15377006636
Email
670196467@qq.com
Country
China
ProdList
31
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from Fmoc-His(Trt)-OH manufacturers

R&D Scientific Inc.
Product
Fmoc-His(Trt)-OH 109425-51-6
Price
US $490.00/g
Min. Order
1g
Purity
99 %
Supply Ability
5000 Kg
Release date
2025-06-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fmoc-His(Trt)-OH 109425-51-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-26
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-His(Trt)-OH 109425-51-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-13

109425-51-6, Fmoc-His(Trt)-OHRelated Search:

L-Fmoc-Aspartic acid alpha-tert-butyl ester Trityl candesartan Nalpha-Fmoc-Ndelta-trityl-L-glutamine Trityl Irbesartan Trityl candesartan cilexetil Fmoc-Lys(Boc)-OH 9-Fluorenylmethyl chloroformate Fmoc-Asp(OtBu)-OH L-Histidine Triphenylmethyl Chloride p-Toluic acid Fmoc-Phe-OH N-Fmoc-N'-trityl-D-histidine Fmoc-D-Asn(Trt)-OH N-Fmoc-N'-tosyl-L-arginine N-Fmoc-S-trityl-D-cysteine Fmoc-OSu N-Boc-N'-trityl-L-glutamine

  • FMOC-N-IM-TRITYL-L-HISTIDINE
  • FMOC-HISTIDINE(1-TRT)-OH
  • FMOC-HIS(TRITYL)-OH
  • FMOC-HIS(TRT)
  • FMOC-HIS(TRT)-OH
  • FMOC-HIS(T-TRT)-OH
  • FMOC-HIS(1-TRT)-OH
  • FMOC-L-HIS(TRITYL)
  • FMOC-L-HIS(TRT)-OH
  • FMOC-L-HISTIDINE(TRITYL)
  • FMOC-L-HISTIDINE (TRT)
  • N<SUB>α</SUB>-Fmoc-N<SUB>(im)</SUB>-trityl-L-histidine
  • N-α-Fmoc-N-im-trityl-L-histidine
  • NALPHA-9-Fluorenylmethoxycarbonyl-N-imidazole-(trityl)-L-histidine
  • FMOC-N-IM-TRITYL-L-HISTIDINE (FMOC-L-HIS(TRT)-OH)
  • N-(ALPHA)-FMOC-N-(TRITYL)-L-HISTIDINE
  • Fmoc-His(trityl resin)-NH2
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-L-HISTIDINE
  • Fmoc-His(tau-Trt)-OH
  • Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine
  • Nα-Fmoc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)
  • Fmoc-L-His(trityl resin)-NH2
  • Fmoc-L-histidine(2-chlorotrityl resin)amide
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl His(Trt)-OH
  • Fomc-His(Trt)-OH
  • (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1-trityl-1H-iMidazol-4-yl)propanoic acid
  • N-FMoc-1-trityl-L-histidine, 98%
  • Fmoc-His(Trt)-OH >=98.0% (sum of enantiomers, HPLC)
  • -trityl-L-histidine
  • (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
  • Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine
  • Nalpha-Fmoc-tele-trityl-L-histidine
  • Fmoc-His(Trt)-OH ,99%
  • N-FMOC-HIS(TRITYL RESIN)-NH2
  • N-FMOC-N-TRITYL-L-HISTIDINE
  • Nalpha-(9-fluorenylmethoxycarbonyl)-N-trityl-L-histidine
  • Fmoc-his(trityl)-OH, Fmoc-His(Trt)-OH, Nα-Fmoc-N(im)-trityl-L-histidine
  • Nalpha-FMOC-N-trityl-L-histidine,95%
  • NA-FMOC-NIM-TRITYL-L-HISTIDINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-TAU-TRITYL-L-HISTIDINE
  • N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIM-TRITYL-L-HISTIDINE
  • N-9-Fluorenylmethoxycarbonyl-N'-trityl-L-histidine
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IM-TRITYL-L-HISTIDINE
  • N-ALPHA-FMOC-N-IM-TRITYL-L-HISTIDINE
  • N-Fmoc-N'-trityl-L-h
  • Fmoc-Histidine-(trt)-OH
  • L-HISTIDINE-N-FMOC, N-IM-TRITYL
  • FMoc-His(Trt)-OH N-α-FMoc-N-iM-trityl-L-histidine
  • Nalpha-Fmoc-tele-trityl-L-histidine Fmoc-His(Trt)-OH
  • N^a-FMoc-1-trityl-L-histidine, 98%
  • 2-[[4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid
  • Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine&gt
  • FMOC-HIS(TRT)-OH 250 G
  • FMOC-HIS(TRT)-OH 100 G
  • FMOC-HIS(TRT)-OH 25 G
  • N-Fmoc-N'-trityL
  • L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-
  • (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid