H-His(Trt)-OH

Product Name: H-His(Trt)-OH
CAS No.: 35146-32-8
Chemical Name: H-His(Trt)-OH
Synonyms: His(Trt);L-His(Trt);L-His(Trt)-OH;H-HIS(TRT)-OH;L-His(Trt)·H2O;H-L-HIS(TRT)-OH;H-HIS(T-TRT)-OH;H-HIS(1-TRT)-OH;H-His(tau-Trt)-OH;HISTIDINE(1-TRT)-OH
CBNumber: CB9185713
Molecular Formula: C25H23N3O2
Formula Weight: 397.47
MOL File: 35146-32-8.mol

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H-His(Trt)-OH Property

Melting point:: 210℃
Boiling point:: 584.8±50.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 1.78±0.10(Predicted)
form: Solid
InChI: InChI=1S/C25H23N3O2/c26-23(24(29)30)16-22-17-28(18-27-22)25(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,23H,16,26H2,(H,29,30)/t23-/m0/s1
InChIKey: BSZQZNOAYQCQFZ-QHCPKHFHSA-N
SMILES: C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)N

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Safety

WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H62779
Product name: 1-Trityl-L-histidine, 98%
Packaging: 1g
Price: $48.65
Updated: 2024/03/01

Alfa Aesar

Product number: H62779
Product name: 1-Trityl-L-histidine, 98%
Packaging: 5g
Price: $171.65
Updated: 2024/03/01

TRC

Product number: T808775
Product name: 1-(Triphenylmethyl)-L-histidine
Packaging: 10g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 285606
Product name: Nim-Trityl-histidine
Packaging: 2g
Price: $333
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002849
Product name: H-HIS(TRT)-OH
Purity: 95.00%
Packaging: 1G
Price: $151.83
Updated: 2021/12/16

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H-His(Trt)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-(Triphenylmethyl)-L-histidine is a reactant in the synthesis of falcitidin acyl tetrapeptides as antimalarial agent.

Preparation

The amino acid N(im)-trityl-D-histidine was dissolved in dichloromethane, followed by the addition of triethylamine and trimethylsilyl chloride (3.5 equivalents). After 2 hours of gentle reflux, the mixture was ready to be used for in situ coupling to the anhydride of the carboxylic acid. Thus, isovaleric acid was separately dissolved in THF and maintained at -20 ℃ using an ice-salt bath. N-methyl morpholine (1.2 equivalents) was added, followed by the addition of ethyl chloroformate (1.0 equivalent). After 15-20 minutes at -20 ℃, the bis-TMS amino acid reaction mixture was added directly to the anhydride solution and left stirring at room temperature overnight. After 8 hours, the reaction mixture was concentrated in vacuo. Finally, H-His(Trt)-OH was obtained after purification.

Definition

H-His(Trt)-OH, also known as 1-(Triphenylmethyl)-L-histidine, is a histidine derivative. It can be obtained by removing fmoc group protection from Fmoc-His(Trt)-OH. L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system.

H-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-His(Trt)-OH Suppliers

China 150 France 1 Germany 4 Hungary 1 India 2 Japan 2 South Korea 1 Switzerland 2 United Kingdom 1 United States 15 Global 179

J & K SCIENTIFIC LTD.

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Alfa Aesar

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Energy Chemical

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Chemsky (shanghai) International Co.,Ltd

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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View Lastest Price from H-His(Trt)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-His(trt)-OH 35146-32-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%;99%
Supply Ability: 1T+
Release date: 2023-09-08

Sichuan Jiaying Lai Technology Co.,LTD

Product: H-His(trt)-OH 35146-32-8
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-25

Career Henan Chemical Co

Product: H-HIS(TRT)-OH 35146-32-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

35146-32-8, H-His(Trt)-OHRelated Search:

Methyl L-histidinate dihydrochloride H-HIS(BZL)-OH 3-METHYL-L-HISTIDINE H-His(Trt)-OMe · HCl 3,5-DIIODO-D-TYROSINE HYDROCHLORIDE Fmoc-His(Trt)-OH N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester H-His(Trt)-OH Boc-His(Trt)-OH TRT-OH N-Boc-S-Trityl-L-cysteine N-Boc-N'-trityl-L-glutamine N-FMOC-GLY(TRT)-OH Z-GLN(TRT)-OH,Z-GLUTAMINE(TRT)-OH FMOC-D-PEN(TRT)-OH Z-ASN(TRT)-OH Fmoc-Asn(Trt)-OH H-GLN(TRT)-OH

N-τ-Trityl-L-histidine

1-(Triphenylmethyl)-L-histidine

L-His(Trt)·H2O

L-His(Trt)-OH

Nim-Trityl-histidine≥ 98% (HPLC)

(2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicacid

1-Trityl-L-histidine, 98%

H-L-HIS(TRT)-OH

HISTIDINE(1-TRT)-OH

H-HIS(1-TRT)-OH

H-HIS(T-TRT)-OH

H-HIS(TRT)-OH

RARECHEM AL BE 1480

N-IM-TRITYL-HISTIDINE

N-IM-TRITYL-L-HISTIDINE

N-TAU-TRITYL-L-HISTIDINE

His(Trt)

N<T/(IM)>-TRITYL-L-HISTIDINE

H-His(tau-Trt)-OH

(2S)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid

(2S)-2-amino-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid

L-His(Trt)

(2S)-2-ammonio-3-(1-trityl-1H-imidazol-4-yl)propanoate

(S)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)propanoicacid

L-Histidine, 1-(triphenylmethyl)-

(2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicaci

H-HIS(TRT)-OH USP/EP/BP

35146-32-8

C25H23N3O2

Histidine

Peptide Synthesis

Specialty Synthesis

Amino Acid Derivatives

Histidine [His, H]

Amino Acids and Derivatives

Amino Acid Derivatives

Histidine

Peptide Synthesis