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H-His(Trt)-OH

Product Name
H-His(Trt)-OH
CAS No.
35146-32-8
Chemical Name
H-His(Trt)-OH
Synonyms
His(Trt);L-His(Trt);L-His(Trt)-OH;H-HIS(TRT)-OH;L-His(Trt)·H2O;H-L-HIS(TRT)-OH;H-HIS(T-TRT)-OH;H-HIS(1-TRT)-OH;H-His(tau-Trt)-OH;HISTIDINE(1-TRT)-OH
CBNumber
CB9185713
Molecular Formula
C25H23N3O2
Formula Weight
397.47
MOL File
35146-32-8.mol
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H-His(Trt)-OH Property

Melting point:
210℃
Boiling point:
584.8±50.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
1.78±0.10(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C25H23N3O2/c26-23(24(29)30)16-22-17-28(18-27-22)25(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,23H,16,26H2,(H,29,30)/t23-/m0/s1
InChIKey
BSZQZNOAYQCQFZ-QHCPKHFHSA-N
SMILES
C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)N
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Safety

WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H62779
Product name
1-Trityl-L-histidine, 98%
Packaging
1g
Price
$48.65
Updated
2024/03/01
Alfa Aesar
Product number
H62779
Product name
1-Trityl-L-histidine, 98%
Packaging
5g
Price
$171.65
Updated
2024/03/01
TRC
Product number
T808775
Product name
1-(Triphenylmethyl)-L-histidine
Packaging
10g
Price
$120
Updated
2021/12/16
Usbiological
Product number
285606
Product name
Nim-Trityl-histidine
Packaging
2g
Price
$333
Updated
2021/12/16
Activate Scientific
Product number
AS102790
Product name
H-His(Trt)-OH
Purity
97%
Packaging
1g
Price
$23
Updated
2021/12/16
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H-His(Trt)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-(Triphenylmethyl)-L-histidine is a reactant in the synthesis of falcitidin acyl tetrapeptides as antimalarial agent.

Preparation

The amino acid N(im)-trityl-D-histidine was dissolved in dichloromethane, followed by the addition of triethylamine and trimethylsilyl chloride (3.5 equivalents). After 2 hours of gentle reflux, the mixture was ready to be used for in situ coupling to the anhydride of the carboxylic acid. Thus, isovaleric acid was separately dissolved in THF and maintained at -20 ℃ using an ice-salt bath. N-methyl morpholine (1.2 equivalents) was added, followed by the addition of ethyl chloroformate (1.0 equivalent). After 15-20 minutes at -20 ℃, the bis-TMS amino acid reaction mixture was added directly to the anhydride solution and left stirring at room temperature overnight. After 8 hours, the reaction mixture was concentrated in vacuo. Finally, H-His(Trt)-OH was obtained after purification.

Definition

H-His(Trt)-OH, also known as 1-(Triphenylmethyl)-L-histidine, is a histidine derivative. It can be obtained by removing fmoc group protection from Fmoc-His(Trt)-OH. L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system.

H-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-His(Trt)-OH Suppliers

China 155 France 1 Germany 4 Hungary 1 India 2 Japan 2 South Korea 1 Switzerland 2 United Kingdom 1 United States 15 Global 184
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Senn Chemicals AG
Tel
--
Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
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View Lastest Price from H-His(Trt)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-His(trt)-OH 35146-32-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%;99%
Supply Ability
1T+
Release date
2023-09-08
Sichuan Jiaying Lai Technology Co.,LTD
Product
H-His(trt)-OH 35146-32-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-25
Career Henan Chemical Co
Product
H-HIS(TRT)-OH 35146-32-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

35146-32-8, H-His(Trt)-OHRelated Search:

Methyl L-histidinate dihydrochloride H-HIS(BZL)-OH 3-METHYL-L-HISTIDINE H-His(Trt)-OMe · HCl 3,5-DIIODO-D-TYROSINE HYDROCHLORIDE Fmoc-His(Trt)-OH N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester H-His(Trt)-OH Boc-His(Trt)-OH TRT-OH N-Boc-S-Trityl-L-cysteine N-Boc-N'-trityl-L-glutamine N-FMOC-GLY(TRT)-OH Z-GLN(TRT)-OH,Z-GLUTAMINE(TRT)-OH FMOC-D-PEN(TRT)-OH Z-ASN(TRT)-OH Fmoc-Asn(Trt)-OH H-GLN(TRT)-OH

  • N-τ-Trityl-L-histidine
  • 1-(Triphenylmethyl)-L-histidine
  • L-His(Trt)·H2O
  • L-His(Trt)-OH
  • Nim-Trityl-histidine≥ 98% (HPLC)
  • (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicacid
  • 1-Trityl-L-histidine, 98%
  • H-L-HIS(TRT)-OH
  • HISTIDINE(1-TRT)-OH
  • H-HIS(1-TRT)-OH
  • H-HIS(T-TRT)-OH
  • H-HIS(TRT)-OH
  • RARECHEM AL BE 1480
  • N-IM-TRITYL-HISTIDINE
  • N-IM-TRITYL-L-HISTIDINE
  • N-TAU-TRITYL-L-HISTIDINE
  • His(Trt)
  • N<T/(IM)>-TRITYL-L-HISTIDINE
  • H-His(tau-Trt)-OH
  • (2S)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
  • (2S)-2-amino-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid
  • L-His(Trt)
  • (2S)-2-ammonio-3-(1-trityl-1H-imidazol-4-yl)propanoate
  • (S)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)propanoicacid
  • L-Histidine, 1-(triphenylmethyl)-
  • (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicaci
  • H-HIS(TRT)-OH USP/EP/BP
  • 35146-32-8
  • C25H23N3O2
  • Histidine
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acid Derivatives
  • Histidine [His, H]
  • Amino Acids and Derivatives
  • Amino Acid Derivatives
  • Histidine
  • Peptide Synthesis