ChemicalBook > CAS DataBase List > 5-BROMO-2-CHLORO-3-IODO-PYRIDINE
5-BROMO-2-CHLORO-3-IODO-PYRIDINE
- Product Name
- 5-BROMO-2-CHLORO-3-IODO-PYRIDINE
- CAS No.
- 928653-73-0
- Chemical Name
- 5-BROMO-2-CHLORO-3-IODO-PYRIDINE
- Synonyms
- 2-chloro -5-broMo-3-iodopyridine;Pyridine, 5-bromo-2-chloro-3-iodo-;5-Bromo-2-chloro-3-iodopyridine 98%
- CBNumber
- CB71229304
- Molecular Formula
- C5H2BrClIN
- Formula Weight
- 318.34
- MOL File
- 928653-73-0.mol
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5-BROMO-2-CHLORO-3-IODO-PYRIDINE Property
- Boiling point:
- 301.0±42.0 °C(Predicted)
- Density
- 2.395±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -3.09±0.10(Predicted)
- form
- solid
- color
- Off-white to grey
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- ADE000303
- Product name
- 5-Bromo-2-chloro-3-iodo-pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B6219
- Product name
- 5-Bromo-2-chloro-3-iodopyridine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $85
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B6219
- Product name
- 5-Bromo-2-chloro-3-iodopyridine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $254
- Updated
- 2025/07/31
TRC
- Product number
- B682478
- Product name
- 5-Bromo-2-chloro-3-iodo-pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- B682478
- Product name
- 5-Bromo-2-chloro-3-iodo-pyridine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
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5-BROMO-2-CHLORO-3-IODO-PYRIDINE Chemical Properties,Usage,Production
Synthesis
381233-75-6
928653-73-0
General procedure for the synthesis of 5-bromo-2-chloro-3-iodopyridine from 5-bromo-3-iodopyridin-2(1H)-one: 5-bromo-3-iodopyridin-2(1H)-one (9 g, 30 mmol) was dissolved in 90% phenylphosphonic dichloride (100 mL, 0.3 mol). The reaction mixture was heated with stirring at 160 °C for 4 h and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature, followed by slow dripping into a vessel containing 1 L of water and cooled at 0 °C. The reaction solution was neutralized with NH4OH solution to neutral. The aqueous phase was extracted with ethyl acetate and the organic phase was combined. After treatment, the target product 5-bromo-2-chloro-3-iodopyridine was obtained as a white solid in 82% yield.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1644 - 1668
[2] Patent: WO2015/132727, 2015, A1. Location in patent: Page/Page column 22; 23; 28
5-BROMO-2-CHLORO-3-IODO-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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