5-Hydroxymethyluracil

Product Name: 5-Hydroxymethyluracil
CAS No.: 4433-40-3
Chemical Name: 5-Hydroxymethyluracil
Synonyms: NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL
CBNumber: CB7122987
Molecular Formula: C5H6N2O3
Formula Weight: 142.11
MOL File: 4433-40-3.mol

More

Less

5-Hydroxymethyluracil Property

Melting point:: >300 °C(lit.)
Density: 1.401±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
pka: 8.46±0.10(Predicted)
form: Solid
color: White
Water Solubility: Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol.
BRN: 125482
InChI: InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChIKey: JDBGXEHEIRGOBU-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(CO)C(=O)N1
CAS DataBase Reference: 4433-40-3(CAS DataBase Reference)
EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3)

More

Less

Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: YR0513000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 852589
Product name: 5-(Hydroxymethyl)uracil
Purity: 97%
Packaging: 1g
Price: $28.6
Updated: 2024/03/01

Alfa Aesar

Product number: L01682
Product name: 5-(Hydroxymethyl)uracil, 98%
Packaging: 1g
Price: $38.65
Updated: 2024/03/01

Alfa Aesar

Product number: L01682
Product name: 5-(Hydroxymethyl)uracil, 98%
Packaging: 5g
Price: $129.65
Updated: 2024/03/01

Cayman Chemical

Product number: 89360
Product name: Hydroxymethyl Uracil
Purity: ≥98%
Packaging: 250mg
Price: $12
Updated: 2024/03/01

Cayman Chemical

Product number: 89360
Product name: Hydroxymethyl Uracil
Packaging: 1000mg
Price: $37
Updated: 2024/03/01

More

Less

5-Hydroxymethyluracil Chemical Properties,Usage,Production

Description

5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

Chemical Properties

White Powder

Uses

5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

Definition

ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.

Biosynthesis

5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.

Biotechnological Production

5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.

5-Hydroxymethyluracil Preparation Products And Raw materials

Raw materials

Potassium hydroxide Formaldehyde Hydrochloric acid Uracil

Preparation Products

More

Less

5-Hydroxymethyluracil Suppliers

Austria 1 Canada 1 China 174 Europe 1 Germany 6 India 4 Russia 1 Switzerland 2 United Kingdom 6 United States 28 Global 224

Hangzhou Cheminspire Technology Co., Ltd.

Tel: 0571-89081561; 10006559855
Fax: 0571 89081561
Email: info@cheminspire.com
Country: China
ProdList: 412
Advantage: 58

Shanghai Hengmao Biotechnology Co. , Ltd.

Tel: 18817538189
Email: hmbsales@163.com
Country: China
ProdList: 82
Advantage: 58

Foshan Yuhang New Materials Co., Ltd

Tel: 0757-18928797409 13078814179
Email: 1670287326@qq.com
Country: China
ProdList: 971
Advantage: 58

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1686
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

More

Less

View Lastest Price from 5-Hydroxymethyluracil manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-hydroxymethyluracil 4433-40-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Hydroxymethyluracil 4433-40-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 5-Hydroxymethyluracil 4433-40-3
Price: US $20.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-01

4433-40-3, 5-HydroxymethyluracilRelated Search:

Silver sulfadiazine (Hydroxymethyl)urea Thymine Cytosine Sulfadiazine Uracil Fluorocytosine Pseudouridine 5-CARBETHOXYURACIL 5-HYDROXYMETHYL-2'-DEOXYURIDINE 2,4-Dihydroxypyrimidine-5-carboxylic acid 4-methyl-5-hydroxymethyluraci 2,4-DIMETHOXY-5-PYRIMIDINECARBOXYLIC ACID 5-Hydroxymethyluracil AURORA KA-4984 AURORA KA-4986 methyl 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate AURORA KA-548

3h)-pyrimidinedione,5-(hydroxymethyl)-4(1h

5-(hydroxymethyl)-uraci

RARECHEM AH CK 0115

TIMTEC-BB SBB000084

AURORA KA-547

HYDROXYMETHYL URACIL

5-HYDROXYMETHYLURACIL

5-(HYDROXYMETHYL)URACIL HYDRATE

5-HYDROXYMETHYLURACYL

5-(HYDROXYMETHYL)-2,4(1H,3H)PYRIMIDINEDIONE

2,4-DIHYDROXY-5-HYDROXYMETHYLPYRIMIDINE

2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (9CI)

5-(Hydroxymethyl)uracil,98%

5-(hydroxymethyl)pyrimidine-2,4-dione

uracil-5-methanol

5-(hydroxymethyl)-1H-pyrimidine-2,4-dione

5-methyloluracil

5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione, 5-(Hydroxymethyl)pyrimidine-2,4-diol

5-(hydroxyMethyl)pyriMidine-2

5-(HydroxyMethyl)-1,3-dihydropyriMidine-2,4-dione

NSC 20901

α-HydroxythyMine

5-(hydroxymethyl)pyrimidine-2,4-diol

5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione|5-Hydroxymethyluracil

5-(Hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

a-Hydroxythymine

2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-

4433-40-3

PYRIMIDINE

Nucleotides and Nucleosides

Nucleic acids

5-FOA

Bases & Related Reagents

Nucleotides

Building Blocks

Heterocyclic Building Blocks

Pyrimidines