5-Hydroxymethyluracil
- Product Name
- 5-Hydroxymethyluracil
- CAS No.
- 4433-40-3
- Chemical Name
- 5-Hydroxymethyluracil
- Synonyms
- NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL
- CBNumber
- CB7122987
- Molecular Formula
- C5H6N2O3
- Formula Weight
- 142.11
- MOL File
- 4433-40-3.mol
5-Hydroxymethyluracil Property
- Melting point:
- >300 °C(lit.)
- Density
- 1.401±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
- pka
- 8.46±0.10(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol.
- BRN
- 125482
- InChI
- InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
- InChIKey
- JDBGXEHEIRGOBU-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(CO)C(=O)N1
- CAS DataBase Reference
- 4433-40-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 852589
- Product name
- 5-(Hydroxymethyl)uracil
- Purity
- 97%
- Packaging
- 1g
- Price
- $28.6
- Updated
- 2024/03/01
- Product number
- L01682
- Product name
- 5-(Hydroxymethyl)uracil, 98%
- Packaging
- 1g
- Price
- $38.65
- Updated
- 2024/03/01
- Product number
- L01682
- Product name
- 5-(Hydroxymethyl)uracil, 98%
- Packaging
- 5g
- Price
- $129.65
- Updated
- 2024/03/01
- Product number
- 89360
- Product name
- Hydroxymethyl Uracil
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $12
- Updated
- 2024/03/01
- Product number
- 89360
- Product name
- Hydroxymethyl Uracil
- Packaging
- 1000mg
- Price
- $37
- Updated
- 2024/03/01
5-Hydroxymethyluracil Chemical Properties,Usage,Production
Description
5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
Chemical Properties
White Powder
Uses
5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.
Definition
ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.
Biosynthesis
5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.
Biotechnological Production
5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.
5-Hydroxymethyluracil Preparation Products And Raw materials
Raw materials
Preparation Products
5-Hydroxymethyluracil Suppliers
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- tech@alfa.com
- Country
- India
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- 6905
- Advantage
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View Lastest Price from 5-Hydroxymethyluracil manufacturers
- Product
- 5-hydroxymethyluracil 4433-40-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 5-Hydroxymethyluracil 4433-40-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 5-Hydroxymethyluracil 4433-40-3
- Price
- US $20.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-08-01