5-Hydroxymethyluracil

Product Name: 5-Hydroxymethyluracil
CAS No.: 4433-40-3
Chemical Name: 5-Hydroxymethyluracil
Synonyms: NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL
CBNumber: CB7122987
Molecular Formula: C5H6N2O3
Formula Weight: 142.11
MOL File: 4433-40-3.mol

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5-Hydroxymethyluracil Property

Melting point:: >300 °C(lit.)
Density: 1.401±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
pka: 8.46±0.10(Predicted)
form: Solid
color: White
Water Solubility: Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol.
BRN: 125482
InChI: InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChIKey: JDBGXEHEIRGOBU-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(CO)C(=O)N1
CAS DataBase Reference: 4433-40-3(CAS DataBase Reference)
EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: YR0513000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 852589
Product name: 5-(Hydroxymethyl)uracil
Purity: 97%
Packaging: 1g
Price: $28.6
Updated: 2024/03/01

Alfa Aesar

Product number: L01682
Product name: 5-(Hydroxymethyl)uracil, 98%
Packaging: 1g
Price: $38.65
Updated: 2024/03/01

Alfa Aesar

Product number: L01682
Product name: 5-(Hydroxymethyl)uracil, 98%
Packaging: 5g
Price: $129.65
Updated: 2024/03/01

Cayman Chemical

Product number: 89360
Product name: Hydroxymethyl Uracil
Purity: ≥98%
Packaging: 250mg
Price: $12
Updated: 2024/03/01

Cayman Chemical

Product number: 89360
Product name: Hydroxymethyl Uracil
Packaging: 1000mg
Price: $37
Updated: 2024/03/01

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5-Hydroxymethyluracil Chemical Properties,Usage,Production

Description

5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

Chemical Properties

White Powder

Uses

5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

Definition

ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.

Biosynthesis

5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.

Biotechnological Production

5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.

5-Hydroxymethyluracil Preparation Products And Raw materials

Raw materials

Potassium hydroxide Formaldehyde Hydrochloric acid Uracil

Preparation Products

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5-Hydroxymethyluracil Suppliers

Austria 1 Canada 1 China 174 Europe 1 Germany 6 India 4 Russia 1 Switzerland 2 United Kingdom 6 United States 28 Global 224

SIGMA-RBI

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Country: Switzerland
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Alexis Corporation

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Country: Switzerland
ProdList: 3599
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View Lastest Price from 5-Hydroxymethyluracil manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-hydroxymethyluracil 4433-40-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Hydroxymethyluracil 4433-40-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 5-Hydroxymethyluracil 4433-40-3
Price: US $20.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-01

4433-40-3, 5-HydroxymethyluracilRelated Search:

Silver sulfadiazine (Hydroxymethyl)urea Thymine Cytosine Sulfadiazine Uracil Fluorocytosine Pseudouridine 5-CARBETHOXYURACIL 5-HYDROXYMETHYL-2'-DEOXYURIDINE 2,4-Dihydroxypyrimidine-5-carboxylic acid 4-methyl-5-hydroxymethyluraci 2,4-DIMETHOXY-5-PYRIMIDINECARBOXYLIC ACID 5-Hydroxymethyluracil AURORA KA-4984 AURORA KA-4986 methyl 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate AURORA KA-548

3h)-pyrimidinedione,5-(hydroxymethyl)-4(1h

5-(hydroxymethyl)-uraci

RARECHEM AH CK 0115

TIMTEC-BB SBB000084

AURORA KA-547

HYDROXYMETHYL URACIL

5-HYDROXYMETHYLURACIL

5-(HYDROXYMETHYL)URACIL HYDRATE

5-HYDROXYMETHYLURACYL

5-(HYDROXYMETHYL)-2,4(1H,3H)PYRIMIDINEDIONE

2,4-DIHYDROXY-5-HYDROXYMETHYLPYRIMIDINE

2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (9CI)

5-(Hydroxymethyl)uracil,98%

5-(hydroxymethyl)pyrimidine-2,4-dione

uracil-5-methanol

5-(hydroxymethyl)-1H-pyrimidine-2,4-dione

5-methyloluracil

5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione, 5-(Hydroxymethyl)pyrimidine-2,4-diol

5-(hydroxyMethyl)pyriMidine-2

5-(HydroxyMethyl)-1,3-dihydropyriMidine-2,4-dione

NSC 20901

α-HydroxythyMine

5-(hydroxymethyl)pyrimidine-2,4-diol

5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione|5-Hydroxymethyluracil

5-(Hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

a-Hydroxythymine

2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-

4433-40-3

PYRIMIDINE

Nucleotides and Nucleosides

Nucleic acids

5-FOA

Bases & Related Reagents

Nucleotides

Building Blocks

Heterocyclic Building Blocks

Pyrimidines