Tandospirone citrate

ChemicalBook > CAS DataBase List > Tandospirone citrate

Physical Form

Product Name: Tandospirone citrate
CAS No.: 112457-95-1
Chemical Name: Tandospirone citrate
Synonyms: andospironecitrate;SM 3997;Methanospirone;SM-3997 citrate;tandospirone citrate;Tandopsirone citrate;Tandospirone-d8 Citrate;Tandospirone citrate (SM 3997);2-(Dicyclohexylphosphanyl)-1-(2-methoxy-6-(triethylsilyl)phenyl)-1H-pyrrole;(3aR,4R,7S,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
CBNumber: CB71270043
Molecular Formula: C21H29N5O2.C6H8O7
Formula Weight: 575.615
MOL File: 112457-95-1.mol

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Tandospirone citrate Property

Melting point:: 169.5-170°
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: Solid
color: White to off-white
Water Solubility: Water: 10.4 mg/mL (18.07 mM)
InChIKey: DMLGUJHNIWGCKM-DPFKZJTMNA-N
SMILES: [C@@]12(C(=O)N(CCCCN3CCN(C4=NC=CC=N4)CC3)C(=O)[C@]1([C@@]1(CC[C@]2(C1)[H])[H])[H])[H].C(O)(C(=O)O)(CC(=O)O)CC(=O)O |&1:0,22,23,26,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4598
Product name: Tandospirone(citrate)
Purity: 98.87%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-4598
Product name: Tandospirone(citrate)
Purity: 98.87%
Packaging: 10mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-4598
Product name: Tandospirone(citrate)
Purity: 98.87%
Packaging: 25mg
Price: $336
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015552
Product name: TANDOSPIRONE CITRATE
Purity: 95.00%
Packaging: 5MG
Price: $503.76
Updated: 2021/12/16

Crysdot

Product number: CD31004535
Product name: Tandospironecitrate
Purity: 98+%
Packaging: 25mg
Price: $194
Updated: 2021/12/16

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Tandospirone citrate Chemical Properties,Usage,Production

Physical Form

solid

Uses

Tandospirone citrate is a potent 5-HT1A partial agonist with a Ki value of 27 nM. Tandospirone citrate is approximately two to three orders of magnitude less potent at 5-HT2, 5-HT1C, alpha 1-adrenergic, alpha 2-adrenergic, and dopamine D1 and D2 receptors (Ki values ranging from 1300 to 41000 nM).
Anti-anxiety agent.

Definition

ChEBI: Tandospirone citrate is a citrate salt of tandospirone , comprising equimolar amounts of citric acid and tandospirone. It is an anxiolytic drug used in the treatment of anxiety disorders. It has a role as an anxiolytic drug and an antidepressant. It contains a tandospirone(1+).

Pharmacology

Tandospirone citrate is a partial agonist of the 5-hydroxytryptamine type 1A (5-HT1A) receptor,which selectively binds to the 5-HT1A receptor in the brain. The anti-anxiety effect is exerted by inhibiting the activities of the 5-HT1A system via selectively stimulating the 5-HT1A receptor widely distributed in these sites.

Side effects

The most common adverse reactions to Tandospirone citrate include drowsiness, dizziness, headache, nausea, malaise, rash, urticaria and pruritus. In addition, there are some symptoms that require special attention, such as those related to hepatic insufficiency and jaundice: general malaise, loss of appetite, yellowing of the skin and whites of the eyes. Excitement, sweating and trembling associated with serotonin syndrome. Fever, impaired consciousness, sweating associated with malignant syndrome. These symptoms are rarely considered initial symptoms of the indicated adverse reaction. However, if you experience discomfort, contact your doctor immediately.

Tandospirone citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tandospirone citrate manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Tandospirone citrate 112457-95-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-04

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Tandospirone citrate 112457-95-1
Price: US $85.00-850.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-20

Biopole Pharmatech Co., Ltd.

Product: Tandospirone citrate 2563433
Price: US $0.00/g
Min. Order: 1g
Purity: 99.99%HPLC
Supply Ability: 200kg
Release date: 2024-02-04

112457-95-1, Tandospirone citrateRelated Search:

(2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ 696 Impurity C LCZ 696 Impurity B rac-Lipoic Acid Impurity 1 (S-Oxide) 3-(3-fluorobenzyl)-4-(3-fluoro-benzyloxy)benzaldehyde 4-Benzyl Albuterol [R(R*,R*]-2-amino-1-[p-(methylsulphonyl)phenyl]propane-1,3-diol PWKRNMKZGWGSDV-UHFFFAOYSA-N Tandospirone citrate Tandospirone 1,2-Cyclohexanedicarboximide Ammonium citrate tribasic cis-Octahydroisoindole 2-AZACYCLOOCTANONE cis-7-Azabicyclo[3.3.0]octane PIPERAZINE DL-MALATE N-Butyl-2-methyl-succinimide 4-AZA-TRICYCLO[5.2.1.0 2,6 ]DECANE

4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI)

SM 3997

tandospirone citrate

(3aα,4β,7β,7aα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione·citric acid

Methanospirone

Tandopsirone citrate

3aalpha,4alpha,5,6,7alpha,7aalpha-Hexahydro-2-[4- [4-(2-pyriMidinyl)-1-piperazinyl]butyl]-4,7-Methano-1H-isoindole-1,3(2H)-dione dihydrogen citrate

(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

SM-3997 citrate

rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate

andospironecitrate

Tandospirone citrate (SM 3997)

Tandospirone-d8 Citrate

SM3997,SM-3997,Tandospirone,Tandospirone citrate,Inhibitor,Serotonin Receptor,SM 3997,5-hydroxytryptamine Receptor,inhibit,5-HT Receptor

2-(Dicyclohexylphosphanyl)-1-(2-methoxy-6-(triethylsilyl)phenyl)-1H-pyrrole

4-((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate

(1S,2R,3S,4R)-3-((4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid

(3aR,3a'R,4S,4'S,7R,7aS,7'R,7a'S)-2,2'-(piperazine-1,4-diylbis(butane-4,1-diyl))bis(hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione)

(3aR,4R,7S,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate

112457-95-1

C21H29N5O2C6H8O7

112457-95-1

API