ETHYL 3-(N-METHYLAMINO) PROPIONATE

Product Name: ETHYL 3-(N-METHYLAMINO) PROPIONATE
CAS No.: 2213-08-3
Chemical Name: ETHYL 3-(N-METHYLAMINO) PROPIONATE
Synonyms: Ethyl 3-(MethylaMino)propanoate;114537;Ethyl N-Methyl-β-alaninate;Ethyl N-methyl-beta-alaninate;N-Methyl-b-alanine ethyl ester;ethyl N-methyl-2-aminopropionate;β-Alanine, N-methyl-, ethyl ester;ETHYL 3-(N-METHYLAMINO) PROPIONATE;.beta.-Alanine, N-methyl-, ethyl ester;3-methylaminopropionic acid ethyl ester
CBNumber: CB7128338
Molecular Formula: C6H13NO2
Formula Weight: 131.18
MOL File: 2213-08-3.mol

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ETHYL 3-(N-METHYLAMINO) PROPIONATE Property

Boiling point:: 242.49°C (rough estimate)
Density: 1.0070
refractive index: 1.4443 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Oil
pka: 9.55±0.10(Predicted)
color: Colourless
InChI: InChI=1S/C6H13NO2/c1-3-9-6(8)4-5-7-2/h7H,3-5H2,1-2H3
InChIKey: XVIJMHJTEHBUJI-UHFFFAOYSA-N
SMILES: C(=O)(OCC)CCNC

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: TRC-E923360-5G
Product name: Ethyl N-Methyl-b-alaninate
Packaging: 5g
Price: $670
Updated: 2026/06/03

TRC

Product number: TRC-E923360-1G
Product name: Ethyl N-Methyl-b-alaninate
Packaging: 1g
Price: $167
Updated: 2026/06/03

TRC

Product number: TRC-E923360-10G
Product name: Ethyl N-Methyl-b-alaninate
Packaging: 10g
Price: $1257
Updated: 2026/06/03

Matrix Scientific

Product number: 080927
Product name: Ethyl N-methyl-beta-alaninate
Packaging: 500.00mg
Price: $336
Updated: 2026/05/18

Matrix Scientific

Product number: 080927
Product name: Ethyl N-methyl-beta-alaninate
Packaging: 1.00g
Price: $420
Updated: 2026/05/18

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ETHYL 3-(N-METHYLAMINO) PROPIONATE Chemical Properties,Usage,Production

Uses

Ethyl N-Methyl-beta-alaninate is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2124, 1949 DOI: 10.1021/ja01174a061

Synthesis

74-89-5

140-88-5

2213-08-3

1. cool 33% methylamine ethanol solution (100 mL, 805 mmol) in an ice bath at 0 °C. 2. Ethyl acrylate (11.0 mL, 10.1 g, 101 mmol) was added slowly, keeping the reaction temperature at 0 °C with continuous stirring for 2 hours. 3. Gradually warm the reaction mixture to room temperature and continue stirring for 15 minutes. 4. All volatiles were removed by distillation under reduced pressure. 5. The resulting residue (ethyl 3-(methylamino)propionate crude, 11.2 g) was used directly in the subsequent reaction without further purification.

References

[1] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1055 - 1059
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980, p. 1739 - 1745
[3] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 87 - 91
[4] Liebigs Annalen der Chemie, 1980, # 9, p. 1438 - 1447
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 2129

ETHYL 3-(N-METHYLAMINO) PROPIONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3-(N-METHYLAMINO) PROPIONATE Suppliers

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2213-08-3, ETHYL 3-(N-METHYLAMINO) PROPIONATERelated Search:

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ETHYL 3-(N-METHYLAMINO) PROPIONATE

Ethyl N-methyl-beta-alaninate

.beta.-Alanine, N-methyl-, ethyl ester

3-(Methylamino)propionic acid ethyl ester

3-methylaminopropanoic acid ethyl ester

3-methylaminopropionic acid ethyl ester

N-Methyl-b-alanine ethyl ester

114537

β-Alanine, N-methyl-, ethyl ester

Ethyl N-Methyl-β-alaninate

ethyl N-methyl-2-aminopropionate

Ethyl 3-(MethylaMino)propanoate

2213-08-3