ChemicalBook > CAS DataBase List > Perfluorooctyl iodide

Perfluorooctyl iodide

Product Name
Perfluorooctyl iodide
CAS No.
507-63-1
Chemical Name
Perfluorooctyl iodide
Synonyms
HEPTADECAFLUORO-1-IODOOCTANE;1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoro-8-iodooctane;TI-8;C1014NH7;uorooctyL;1-IODOPERFLUOROOCTANE;PERFLUOROOCTYL IODIDE;Perfluorooctyl iodine;Perfluoro-1-iodooctane;Perfluorooctyliodide98%
CBNumber
CB7135961
Molecular Formula
C8F17I
Formula Weight
545.96
MOL File
507-63-1.mol
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Perfluorooctyl iodide Property

Melting point:
25 °C
Boiling point:
160-161 °C(lit.)
Density 
2.067 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.329(lit.)
Flash point:
160-161°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Liquid After Melting
color 
Clear colorless to yellow or light pink
Sensitive 
Light Sensitive
BRN 
1717141
Exposure limits
ACGIH: TWA 0.01 ppm
InChIKey
KWXGJTSJUKTDQU-UHFFFAOYSA-N
CAS DataBase Reference
507-63-1(CAS DataBase Reference)
NIST Chemistry Reference
Perfluorooctyl iodide(507-63-1)
EPA Substance Registry System
Octane, 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodo- (507-63-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 2922
WGK Germany 
3
RTECS 
RG9700050
F 
8
Hazard Note 
Harmful
TSCA 
T
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29037800
Toxicity
LD50 ivn-mus: 7500 mg/kg MIVRA6 8,320,74
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
262544
Product name
Heptadecafluoro-1-iodooctane
Purity
98%
Packaging
5g
Price
$53.9
Updated
2024/03/01
Sigma-Aldrich
Product number
262544
Product name
Heptadecafluoro-1-iodooctane
Purity
98%
Packaging
25g
Price
$99.5
Updated
2024/03/01
TCI Chemical
Product number
P1084
Product name
Heptadecafluoro-n-octyl Iodide
Purity
>98.0%(GC)
Packaging
25g
Price
$118
Updated
2023/06/20
Alfa Aesar
Product number
B20207
Product name
Perfluoro-1-iodooctane, 98%
Packaging
10g
Price
$62.65
Updated
2024/03/01
Alfa Aesar
Product number
B20207
Product name
Perfluoro-1-iodooctane, 98%
Packaging
50g
Price
$214.65
Updated
2024/03/01
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Perfluorooctyl iodide Chemical Properties,Usage,Production

Chemical Properties

clear light pink liquid after melting

Uses

Perfluorooctyl Iodide is a perfluoroalkyl iodide used in organocatalysis via substrate activation by halogen bonding. Perfluorooctyl Iodide is a potential candidate substitute for banned Halon fire extinguishers.

Uses

Heptadecafluoro-1-iodooctane has been used as monodentate donor to investigate anion receptor complexes of mono-, bi- and tridentate donors with a variety of anions in the gas phase using both experimental and theoretical approaches.

Reactivity Profile

1H,1H,2H,2H-1Iodide-Perfluorodecane was synthesized using perfluorooctyl iodide and ethylene as materials, then reacted with sodium methoxide /methanol to gain 1H,1H,2H-Heptadecafluorodecene. Influence factors such as the kinds of solvents, raw material configuration, concentration, and time used in the process of dehydrogen iodide were studied mainly. Optimization was using 1,1,2-Trichloro-1,2,2-trifluoroethane as solvent, sodium methoxide /methanol (2mol/L ), 1H,1H,2H,2H-1Iodide-Perfluorodecane( M1 ): sodium methoxide( M2 ) =1:2, reacted 12 hours, the yield of 1H,1H,2H-Heptadecafluorodecene was up to 80%[4-5].

Cytotoxicity

Exposure of H295R cells to Perfluorooctyl iodide (PFOI) (<100 μM) and Perfluorooctanoic acid (PFOA) (<100 μM) did not cause significant toxicity within the concentration ranges tested (p > 0.05). However, 125 μM PFOI and PFOA induced significant toxicity in H295R cells (p < 0.05). No obvious morphological alterations were observed in the cells treated with PFOI or PFOA at levels lower than 100 μM upon microscopic examination[1].

Biochem/physiol Actions

Levels of aldosterone production, cortisol, and 17β-estradiol were elevated significantly, and the level of testosterone generation decreased upon treatment with 100 μM PFOI. Similar to the effect induced by forskolin (AC activator), expression of all 10 genes involved in synthesizing steroid hormones was upregulated significantly upon exposure to 100 μM PFOI. PFOA had no effect on steroid hormone production or steroidogenic gene expression, even though it is highly structurally similar to PFOI. Therefore, the terminal -CF2I group in PFOI could be a critical factor for the mediation of steroidogenesis. PFOI increased AC activity and cAMP levels in H295R cells, which implied an underlying mechanism for the disturbance of steroidogenesis. These data suggest that PFOI may act as an AC activator, thereby stimulating steroidogenesis by activating a cAMP signaling pathway[3].

Safety Profile

Slightly toxic by intravenous route. When heated to decomposition it emits toxic vapors of Fí and Ií.

Environmental considerations

Production of perfluorooctyl iodide (PFOI) has great commercial value. PFOI is a potential estrogenic compound. Studies have shown that the concentration of PFOI is relatively higher in the air and soil than the concentrations of the other derivatives of Perfluorinated iodine alkanes (PFIs). In addition, the degradation of PFIs can cause the formation of other Perfluorinated iodine alkanes (PFCs), thereby resulting in environmental behaviors similar to those of FTOHs. Release of PFIs may increase the environmental burden of PFCs[1-2].

References

[1] Chang Wang. "Perfluorooctyl Iodide Stimulates Steroidogenesis in H295R Cells via a Cyclic Adenosine Monophosphate Signaling Pathway." Chemical Research in Toxicology 28 5 (2015): 848–854.
[2] WangYichen. "Estrogen-like response of perfluorooctyl iodide in male medaka (Oryzias latipes) based on hepatic vitellogenin induction." Environmental Toxicology 28 10 (2013): 571–8.
[3] Chang Wang. “Perfluorooctyl Iodide Stimulates Steroidogenesis in H295R Cells via a Cyclic Adenosine Monophosphate Signaling Pathway.” Chemical Research in Toxicology 28 5 (2015): 848–854.
[4] Maria Lumbierres, Adelina Vallribera, Marcial Moreno-Ma?as. “Addition of perfluorooctyl iodide to alkenes. Catalysis by triphenylphosphane.” Tetrahedron 58 20 (2002): Pages 4061-4065.
[5] X. Wang, Ai Fu, G. Chang. “Study on Preparation of 1H,1H,2H-Heptadecafluorodecene.” Advanced Materials Research 19 1 (2013): 2332–2335.

Perfluorooctyl iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Perfluorooctyl iodide manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Perfluorooctyl iodide 507-63-1
Price
US $25.60/KG
Min. Order
1KG
Purity
96%
Supply Ability
5000kg
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
Perfluorooctyl iodide 507-63-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-26
Wuhan Silworld Chemical Co.,Ltd
Product
Perfluorooctyl iodide 507-63-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000
Release date
2023-04-28

507-63-1, Perfluorooctyl iodideRelated Search:

Propidium iodide Potassium iodide Povidone iodine 2-Iodo-1,1,1-trifluoroethane Trifluoromethyl iodide Iodine 1H,1H,2H,2H-PERFLUOROOCTYL IODIDE,1H,1H,2H,2H-Perfluorooctyl iodide 97% 1-BROMOPERFLUOROHEXANE 1-BroMoheptadecafluorooctane 1H,1H,2H,2H-Perfluorohexyl iodide 1H,1H,2H-Perfluoro-1-decene Perfluoro-1-iodohexane 1H,1H,2H,2H-Perfluorooctyl acrylate 1H,1H,2H,2H-Perfluorooctanesulfonic acid Perfluoroalkyl Ethylenes (Perfluorobutyl)ethylene (Perfluorohexyl)ethylene Perfluoroalkylethyl acrylate

  • HEPTADECAFLUOROOCTYL IODIDE
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  • HEPTADECAFLUORO-1-IODOOCTANE
  • PERFLUOROOCTYL IODIDE 97%
  • 1-IODOPERFLUOROOCTANE
  • 1-Iodoperfluorooctane, Heptadecafluorooctyl iodide, Perfluorooctyl iodide
  • Perfluorooctyliodide98%
  • Perfluorooctyl iodide, 99% 10GR
  • Perfluorooctyl iodide, 99% 1GR
  • 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-1-iodooctane
  • Perfluorooctyl iodide,99%
  • Heptadecafluoro-1-iodooctane,1-Iodoperfluorooctane, Heptadecafluorooctyl iodide, Perfluorooctyl iodide
  • 1-Iodo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
  • Perfluoro-1-iodooctane, 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoro-8-iodooctane
  • 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodo-octan
  • 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoro-8-iodooctane
  • 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodo-Octane
  • 1-Iodoheptadecafluorooctane
  • 1-iodoperfluorooctane98%
  • heptadecafluoro-1-iodo-octan
  • Octane, 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodo-
  • Octane, heptadecafluoro-1-iodo-
  • Perfluoro-1-iodooctane
  • Heptadecafluoro-n-octyl Iodide, 98.0%(GC)
  • PERFLUORO-N-OCTYL IODIDE
  • PERFLUOROOCTYL IODIDE
  • C1014NH7
  • uorooctyL
  • Heptadecafluoro-n-octylIodide&gt
  • Perfluoro-n-Octyl Iodide,98%
  • Perfluorooctyl iodine
  • Perfluorooctyl iodide ISO 9001：2015 REACH
  • Perfluorooctyl Iodide Cas NO.: 507-63-1
  • TI-8
  • 507-63-1
  • CF3CF27I
  • C8F17I
  • Alkyl
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