artemisic acid
- Product Name
- artemisic acid
- CAS No.
- 80286-58-4
- Chemical Name
- artemisic acid
- Synonyms
- Qinghao acid;Qing Hau acid;Artemisia Acid;artemisic acid;Artimisinic Acid;ARTEMISININIC ACID;(+)-artemisinicaci;(+)-Artemisinic Acid;Artemisic acid, 10 mM in DMSO;4,11(13)-Cadinadien-12-oic acid
- CBNumber
- CB71371483
- Molecular Formula
- C15H22O2
- Formula Weight
- 234.33
- MOL File
- 80286-58-4.mol
artemisic acid Property
- Melting point:
- 129-131℃
- Boiling point:
- 373.6±11.0 °C(Predicted)
- Density
- 1.019
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.32±0.11(Predicted)
- form
- Solid
- color
- White to Pale Yellow
- InChI
- InChI=1/C15H22O2/c1-9-4-6-12-10(2)5-7-13(14(12)8-9)11(3)15(16)17/h8,10,12-14H,3-7H2,1-2H3,(H,16,17)/t10-,12+,13+,14+/s3
- InChIKey
- PLQMEXSCSAIXGB-OGGOGTMWNA-N
- SMILES
- [C@]12([H])C=C(CC[C@@]1([H])[C@@H](CC[C@H]2C(=C)C(=O)O)C)C |&1:0,6,8,11,r|
- LogP
- 5.086 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 25059
- Product name
- Artemisinic Acid
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $43
- Updated
- 2024/03/01
- Product number
- 25059
- Product name
- Artemisinic Acid
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 25059
- Product name
- Artemisinic Acid
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 25059
- Product name
- Artemisinic Acid
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 299948
- Product name
- Artemisic acid
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
artemisic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the Asteraceae plant Artemisia annua.
Uses
Artemisic Acid is a derivative of Artemisinin (A777500), an antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial.
Definition
ChEBI: A monocarboxylic acid that is prop-2-enoic acid which is substituted at position 2 by a 4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl group (the 1S,4R,4aS,8aR diastereoisomer). I is a sesquiterpenoid precursor of artemisinin, obtained from sweet wormwood, Artemisia annua.
Synthesis
125184-95-4
80286-58-4
Jones reagent (1.4 M CrO3 in 2.2 M H2SO4 aqueous solution) was added dropwise to a 1 mL acetone solution containing 0.2 mmol of compound 6 (CAS: 125184-95-4) at 0 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously until complete consumption of Feedstock 6 was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, water and dichloromethane (CH2Cl2) were added to the mixture for extraction. The organic layer was separated and washed with distilled water and subsequently dried with anhydrous magnesium sulfate (MgSO4). The solvent was evaporated under reduced pressure to afford the target product 2-((1R,4R,4aS,8aR)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl)acrylic acid in quantitative yield (confirmed by LC/MS). Compound 2 can be further converted to DHAA (3) according to Roth and Acton in Journal of the Chemical Society, Chemical Communications (1989, 24, 1998) or by catalytic hydrogenation (see Example 4).
References
[1] Patent: US2006/270863, 2006, A1. Location in patent: Page/Page column 19
artemisic acid Preparation Products And Raw materials
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View Lastest Price from artemisic acid manufacturers
- Product
- Dihydroartemisinic Artemisic Acid 80286-58-4
- Price
- US $11.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- Artemisinic acid 80286-58-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-11
- Product
- artemisic acid 80286-58-4
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2018-08-20