amitriptyline N-oxide

Product Name: amitriptyline N-oxide
CAS No.: 4317-14-0
Chemical Name: amitriptyline N-oxide
Synonyms: D07449;amitriptyline N-oxide;Amitriptylinoxide (inn);Amitriptyline Impurity 8;Nortriptyline EP Impurity J;ZPMKQFOGINQDAM-UHFFFAOYSA-N;Amitriptyline N-Oxide (Nortriptyline EP Impurity J);Nortriptyline EP Impurity J (Amitriptyline N-Oxide);Nortriptyline Impurity 10 (Nortriptyline EP Impurity J);3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine oxide
CBNumber: CB71386966
Molecular Formula: C20H23NO
Formula Weight: 293.4
MOL File: 4317-14-0.mol

More

Less

amitriptyline N-oxide Property

Melting point:: 228-230°; mp 102-103°
Boiling point:: 435.25°C (rough estimate)
Density: 1.0552 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Amber Vial, -86°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Light and Temperature Sensitive

More

Less

Safety

Toxicity: LD50 in mice, guinea pigs, rabbits, dogs (mg/kg): between 330-460 orally; in mice, rats: 87, 25 i.v.; 320, 110 i.p. (Friehe, Fontaine).

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015938
Product name: AMITRIPTYLINE-N-OXIDE
Purity: 95.00%
Packaging: 5MG
Price: $501.93
Updated: 2021/12/16

More

Less

amitriptyline N-oxide Chemical Properties,Usage,Production

Originator

Equilibrin,Nattermann,W. Germany,1980

Uses

Amitriptyline N-oxide is used in biological studies to metabolize drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS. This compound is also used in the development of antidepressant drugs.

Definition

ChEBI: Amitriptylinoxide is an organic tricyclic compound.

Manufacturing Process

31.3 g (0.1 mol) of 3-(3'-dimethylaminopropylidene)dibenzo[a,d]cyclohepta- 1,4-diene hydrochloride are dissolved in water, and the free base is liberated by means of a 28% aqueous solution of sodium hydroxide. The free base is sucked off, washed with water, and dissolved in 100 ml of methanol. To the solution are added 31 ml of 30% hydrogen peroxide. After 7 days, the reaction mixture is diluted with 200 ml of water, and the major part of the methanol is evaporated in vacuum. The precipitated N-oxide crystals are filtered off, washed with water, and dried, yielding 27 g of the dihydrate of 3- (3'-dimethylaminopropylidene)dibenzo[a,d]cyclohepta-1,4-diene N-oxide with melting point of 102° to 103°C. In dehydrated state the melting point is 228°C to 230°C.
By dissolving the N-oxide in acetone, and bubbling dry hydrogen chlorine gas through the solution until slightly acid reaction, the hydrochloride of the Noxide is precipitated as a white crystalline substance with melting point of 172°C to 173.6°C.
The starting material can be prepared in known manner from dibenzo[a,d]cyclohepta-1,4-diene-5-one by a Grignard reaction with 3- dimethylaminopropyl magnesium chloride, hydrolysis and dehydration of the resulting carbinol.

Therapeutic Function

Antidepressant

Safety Profile

Poison by ingestion,intraperitoneal, and intravenous routes. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx.

amitriptyline N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

amitriptyline N-oxide Suppliers

China 18 India 7 United States 5 Global 30

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

Shanghai ring qi biological technology co., LTD

Tel: 13524106587
Email: sales@hq-chem.com
Country: China
ProdList: 225
Advantage: 58

Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.

Tel: 029-88380327 17691182729
Fax: 029-88380327
Email: 1018@dideu.com
Country: China
ProdList: 1993
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8647
Advantage: 58

Xi'an MC Biotech, Co., Ltd.

Tel: 029-89275612 +8618991951683
Fax: 8618991951683
Email: mcbio_sales@163.com
Country: China
ProdList: 2251
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Shanghai Chino Pharmaceutical Technology Co., Ltd

Tel: 021-021-51557188 15901710861
Fax: QQ: 569058060
Email: sales@channelpharm.com
Country: China
ProdList: 1210
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3006
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940; 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 10005
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627753421 18627756402
Fax: QQ：3001051413
Email: 3001009495@qq.com
Country: China
ProdList: 19063
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43340
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

4317-14-0, amitriptyline N-oxideRelated Search:

Amitriptyline NORTRIPTYLINE Trimethylamine N-oxide 1,1-DI(O-TOLYL)ETHYLENE 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE amitriptyline N-oxide AMITRIPTYLINE-D3 HCL (N-METHYL-D3) 10-hydroxyamitriptyline 5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL DIBENZOSUBERENOL NORTRIPTYLINE HYDROCHLORIDE Dibenzosuberone Cyclobenzaprine hydrochloride AMITRIPTYLINE HCL (D6) DIBENZOSUBEROL 10-Hydroxy Amitriptyline Oxalate Amitriptyline EP Impurity E HCl (Mixture of Diastereomers) amitriptyline N-glucuronide

ZPMKQFOGINQDAM-UHFFFAOYSA-N

Nortriptyline EP Impurity J

amitriptyline N-oxide

Amitriptylinoxide (inn)

D07449

1-?Propanamine, 3-?(10,?11-?dihydro-?5H-?dibenzo[a,?d]?cyclohepten-?5-?ylidene)?-?N,?N-?dimethyl-?, N-?oxide

Amitriptyline N-Oxide (Nortriptyline EP Impurity J)

Nortriptyline Impurity 10 (Nortriptyline EP Impurity J)

Nortriptyline EP Impurity J (Amitriptyline N-Oxide)

Amitriptyline Impurity 8

3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl]dimethylamine N-oxide (amitriptyline-N-oxide)

3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine oxide

4317-14-0