Methyl 3-hydroxy-4-methoxybenzoate
- Product Name
- Methyl 3-hydroxy-4-methoxybenzoate
- CAS No.
- 6702-50-7
- Chemical Name
- Methyl 3-hydroxy-4-methoxybenzoate
- Synonyms
- METHYL ISOVANILLATE;RARECHEM AL BF 0068;Methyl 3-hydroxy-4-m;MethylIsovanillate>3-hydroxy-4-methoxybenzoate;Isovanillic Acid Methyl Ester;METHYL 3-HYDROXY-4-METHOXYBENZOATE;Methyl 3-hydroxy-4-methoxylbenzoate;Methyl 3-hydroxy-4-methoxybenzoate,98%;Methyl 3-hydroxy-4-methoxybenzoate 98%
- CBNumber
- CB7139040
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 6702-50-7.mol
Methyl 3-hydroxy-4-methoxybenzoate Property
- Melting point:
- 64-67 °C (lit.)
- Boiling point:
- 102 °C(Press: 0.1 Torr)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 9.15±0.10(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C9H10O4/c1-12-8-4-3-6(5-7(8)10)9(11)13-2/h3-5,10H,1-2H3
- InChIKey
- QXOXUEFXRSIYSW-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(OC)C(O)=C1
- LogP
- 1.750 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 470708
- Product name
- Methyl 3-hydroxy-4-methoxybenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $28
- Updated
- 2023/06/20
- Product number
- M2205
- Product name
- Methyl Isovanillate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- M2205
- Product name
- Methyl Isovanillate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- M323475
- Product name
- Methyl 3-hydroxy-4-methoxybenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M323475
- Product name
- Methyl 3-hydroxy-4-methoxybenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Methyl 3-hydroxy-4-methoxybenzoate Chemical Properties,Usage,Production
Chemical Properties
Off-white to beige crystalline powder
Uses
Methyl 3-hydroxy-4-methoxybenzoate may be used as starting reagent in the novel synthesis of gefitinib. Synthesis involves the alkylation of starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. It may be used as starting reagent in the synthesis of methyl 5-(benzo[d][1,3]dioxol-5-yl)-4-methoxy-2-nitrobenzoate.
Synthesis
67-56-1
645-08-9
6702-50-7
To a dry 100 mL three-necked flask, 10 g of 3-hydroxy-4-methoxybenzoic acid, 110 mL of methanol, and 360 μL of concentrated sulfuric acid were sequentially added, and the mixture was heated to 65 °C and reacted under magnetic stirring overnight. The reaction process was monitored by thin layer chromatography (unfolding agent: ethyl acetate/dichloromethane=1:1). Upon completion of the reaction, the reaction mixture was transferred to a round bottom flask and methanol was removed by distillation under reduced pressure. The residue was extracted with 25 mL of ethyl acetate and neutralized with 15 mL of saturated sodium bicarbonate solution. After evaporation of ethyl acetate, the solid product methyl 3-hydroxy-4-methoxybenzoate was obtained as 9.06 g in 83.6% yield.
References
[1] Patent: WO2005/9389, 2005, A2. Location in patent: Page/Page column 139
[2] Patent: WO2005/9389, 2005, A2. Location in patent: Page/Page column 139
[3] Journal of Organic Chemistry, 1985, vol. 50, # 2, p. 217 - 231
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2893 - 2897
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 11, p. 3061 - 3068
Methyl 3-hydroxy-4-methoxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-hydroxy-4-methoxybenzoate manufacturers
- Product
- methyl 3-hydroxy-4-methoxybenzoate 6702-50-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26