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trans-4-Aminocyclohexanol

Description Reference
Product Name
trans-4-Aminocyclohexanol
CAS No.
27489-62-9
Chemical Name
trans-4-Aminocyclohexanol
Synonyms
(1r,4r)-4-aminocyclohexanol;(1s,4s)-4-Aminocyclohexanol;trans-4-aminocyclohexan-1-ol;AURORA KA-7506;trans-4-AminocycL;TIMTEC-BB SBB005825;trans-4-Aminocyclohe;Ambroxol Impurity 36;4-(E)-aMino cyclohexano;Ammonia bromine AMB - F
CBNumber
CB7139383
Molecular Formula
C6H13NO
Formula Weight
115.17
MOL File
27489-62-9.mol
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trans-4-Aminocyclohexanol Property

Melting point:
108-113°C
Boiling point:
127 °C / 14mmHg
Density 
0.9837 (rough estimate)
refractive index 
1.4713 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Crystals
pka
15.12±0.40(Predicted)
color 
White to almost white
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
LogP
-0.4
CAS DataBase Reference
27489-62-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C,Xn
Risk Statements 
36/37/38-34-41-37/38-22
Safety Statements 
26-37/39-45-36/37/39-39
RIDADR 
3259
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A1160
Product name
trans-4-Aminocyclohexanol
Purity
>98.0%(GC)
Packaging
25g
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
A1160
Product name
trans-4-Aminocyclohexanol
Purity
>98.0%(GC)
Packaging
500g
Price
$363
Updated
2024/03/01
Alfa Aesar
Product number
B22365
Product name
trans-4-Aminocyclohexanol
Purity
98+%
Packaging
5g
Price
$42.65
Updated
2024/03/01
Alfa Aesar
Product number
B22365
Product name
trans-4-Aminocyclohexanol
Purity
98+%
Packaging
25g
Price
$138.65
Updated
2024/03/01
Alfa Aesar
Product number
B22365
Product name
trans-4-Aminocyclohexanol
Purity
98+%
Packaging
100g
Price
$408.65
Updated
2024/03/01
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trans-4-Aminocyclohexanol Chemical Properties,Usage,Production

Description

Trans-4-Aminocyclohexanol is also named as Cis-4-Aminocyclohexanol. It was a medical intermediate of ambroxol, which is used in the treatment of respiratory diseases associated with viscid or excessive mucus.1 It is used as a raw material in organic synthesis, such as in the synthesis of N-substituted 7-azabicyclo [2.2.1] hepatanes, which are good substrates for microbial oxidation of unactivated carbons by B.bassiana.2

Reference

  1. Y. Jian, Improved Process of the Synthesis of Trans-4-aminocyclohexanol, Fine Chemicals, 2000, vol. 2
  2. H. F. Olivo, M. S. Hemenway, M. H. Gezginci, Synthesis and Microbial Hydroxylation of Some Azabicycloalkanes, Tetrahedron Letters, 1998, vol. 39, pp. 1309-1312

Chemical Properties

white to light yellow crystal powder

Uses

trans-4-aminocyclohexanol be used as organic intermediates.

Uses

trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol.

trans-4-Aminocyclohexanol Preparation Products And Raw materials

Raw materials

1,4-Cyclohexanedione Lithium Aluminum Hydride

Preparation Products

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trans-4-Aminocyclohexanol Suppliers

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View Lastest Price from trans-4-Aminocyclohexanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Trans-4-Aminocyclohexanol 27489-62-9
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-23
airuikechemical co., ltd.
Product
Trans-4-aminocyclohexanol 27489-62-9
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Hebei Weibang Biotechnology Co., Ltd
Product
trans-4-Aminocyclohexanol 27489-62-9
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-21

27489-62-9, trans-4-AminocyclohexanolRelated Search:

Molasses 1-Methylcyclohexanol Cyclohexanol trans-4-Aminocyclohexanol hydrochloride 2-Aminocyclohexanol trans,trans-2,4-Undecadienal Cyclamic acid 4-Aminocyclohexanol Cyclohexanol, 4-amino-1-methyl-, trans- (9CI) (E,E)-2,4-Hexadien-1-ol TRANS-4-AMINO-CYCLOHEXANE CARBOXYLIC ACID HYDROCHLORIDE trans-4-Aminocyclohexanecarbonitrile Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride Trans-4-Propylcyclohexyl-Benzene Trans-1-(bromomethyl)-4-propylcyclohexane 4-(trans-4-Propylcyclohexyl)phenol trans-4-(4n-Heptylcyclohexyl)phenol trans-4-ethylcyclohexylbenzene

  • trans-4-Aminocyclohexanol,97%
  • trans-4-Aminocyclohexanol
  • (1r,4r)-4-aminocyclohexanol
  • (1s,4s)-4-Aminocyclohexanol
  • Trans-4-Amimocyclohexanol
  • Cyclohexanol, 4-amino-, trans-
  • (1α)-4β-Aminocyclohexanol
  • trans-4-Aminocyclohexanol ,99%
  • trans-4-Aminocyclohe
  • Trans-4-aMniocyclohexanol
  • 4-trans-Hydroxycyclohexylamine
  • 4-(E)-aMino cyclohexano
  • Trans-4-aMino cyclohexanol (TACH)
  • <i>trans</i>-4-Aminocyclohexanol
  • The trans-aminocyclohexanol
  • trans-1-amino-4-cyclohexanol
  • TIMTEC-BB SBB005825
  • TRANS-4-AMINO-1-HYDROXYCYCLOHEXANE
  • AMINOCYCLOHEXANOL(TRANS-4)
  • trans-4-aminocyclohexan-1-ol
  • 4-Trans amino cyclohexanol
  • trans-4-Aminocyclohexanol, 98+%
  • AURORA KA-7506
  • trans-4-hydroxycyclohexylamine
  • trans-4-Aminocyclohexanol 97%
  • Trans-4-Aminocyclohexanol ( For Ambroxol Hcl )
  • trans-4-AminocycL
  • Ambroxol Hydrochloride Impurity 4
  • trans-4-Aminocyclohexanol&gt
  • Ambroxol Impurity 36
  • Ammonia bromine AMB - F
  • Trans-4-Amonocyclohexanol
  • Trans-4-amino cyclohexyl phenol
  • Anti-4-amino cyclohexanol
  • rans-4-Aminocyclohexanol
  • (1r,4r)-4-aminocyclohexan-1-ol
  • (1r,4r)-4-aminocyclohexanol/trans-4-Aminocyclohexanol
  • 27489-62-9
  • 50910-58-5
  • 27489-63-9
  • chiral
  • Amines
  • blocks
  • BuildingBlocks
  • Ambroxol
  • 1