ChemicalBook > CAS DataBase List > PRUNINDIHYDROCHALCONE

PRUNINDIHYDROCHALCONE

Product Name
PRUNINDIHYDROCHALCONE
CAS No.
4192-90-9
Chemical Name
PRUNINDIHYDROCHALCONE
Synonyms
trilobin;Trilobatin;p-Phlorizin;p-Phloridzin;Trilobatin-RM;TRILOBATIN(SH);TRILOBATIN(AS) 10mg;PRUNINDIHYDROCHALCONE;Phloretin 4'-glucoside;Trilobatin, 10 mM in DMSO
CBNumber
CB71426381
Molecular Formula
C21H24O10
Formula Weight
436.41
MOL File
4192-90-9.mol
More
Less

PRUNINDIHYDROCHALCONE Property

Melting point:
170-173 °C
Boiling point:
787.9±60.0 °C(Predicted)
Density 
1.555±0.06 g/cm3(Predicted)
FEMA 
4674 | TRILOBATIN
storage temp. 
4°C, protect from light
solubility 
DMF: 20 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.1 mg/ml
form 
A crystalline solid
pka
6.85±0.40(Predicted)
color 
White to off-white
JECFA Number
2171
InChIKey
GSTCPEBQYSOEHV-LKLLPNDVNA-N
SMILES
C(C1C(=CC(O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=1O)O)(=O)CCC1C=CC(O)=CC=1 |&1:6,7,8,10,12,r|
LogP
1.36
More
Less

Safety

HS Code 
29329990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
T4092
Product name
Trilobatin
Packaging
100MG
Price
$178
Updated
2025/07/31
Cayman Chemical
Product number
25837
Product name
Trilobatin
Packaging
1mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
25837
Product name
Trilobatin
Packaging
10mg
Price
$323
Updated
2024/03/01
Cayman Chemical
Product number
25837
Product name
Trilobatin
Packaging
5mg
Price
$242
Updated
2024/03/01
Usbiological
Product number
301076
Product name
Trilobatin
Packaging
20mg
Price
$390
Updated
2021/12/16
More
Less

PRUNINDIHYDROCHALCONE Chemical Properties,Usage,Production

Chemical Properties

Soluble in organic solvents such as methanol, ethanol, and DMSO.

Uses

Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd[1], Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

Definition

ChEBI: Trilobatin is an aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties. It has a role as an anti-inflammatory agent, a sweetening agent, an antioxidant and a plant metabolite. It is an aryl beta-D-glucoside, a member of dihydrochalcones and a monosaccharide derivative. It is functionally related to a phloretin.

IC 50

HIV-1; SGLT1; SGLT2

References

[1] Gao J, et al. Trilobatin?Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci.?2018 Jul 30;11:267. DOI:10.3389/fnmol.2018.00267
[2] Yin S,?et al. Trilobatin?as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett.?2018 Jul;592(13):2361-2377. DOI:10.1002/1873-3468.13113

PRUNINDIHYDROCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PRUNINDIHYDROCHALCONE Suppliers

China 162 United Kingdom 1 United States 13 Global 176
Nanjing Duolong Bio-tech Co.,Ltd.
Tel
18905173768
Fax
025-83263139
Email
52513593@qq.com
Country
China
ProdList
2331
Advantage
50
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Chengdu Herbpurify Co.Ltd.
Tel
2355253622; 18981954830
Fax
086-28-85377358
Email
2355253622@qq.com;
Country
China
ProdList
1103
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9979
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Hubei kangen Pharmaceutical Chemical Co., Ltd
Tel
153-15337215803 15337215803
Fax
027-89771658
Email
3357312443@qq.com
Country
China
ProdList
695
Advantage
56
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4808
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Yihe Biological Technology Co., Ltd.
Tel
021-68882955 17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
4991
Advantage
58
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5093
Advantage
55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5095
Advantage
55
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-028-85370565-229-229 18080489829
Email
18080489829@163.com
Country
China
ProdList
8250
Advantage
60
LinkChem Technology Co., Ltd.
Tel
021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
2998
Advantage
58
Chengdu Alfa Biotechnology Co.,Ltd.
Tel
028-85142057, 18030712385
Fax
028-85142057 QQ:3591697873
Email
sales@alfabiotech.com
Country
China
ProdList
1925
Advantage
58
Shanghai Standard Technology Co.,Ltd.
Tel
021-021-57127007-6622-6622 17621252073
Fax
+86 (21) 5132-0077
Email
luzh@nature-standard.com
Country
China
ProdList
3021
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Shanghai Innovative Reseach Center Of Traditional
Tel
86-21-50801717-301
Fax
86-21-50800509
Email
wangjh@sirc-tcm.sh.cn
Country
China
ProdList
2070
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
Linyi Azelasi Biological Co., Ltd.
Tel
17753923223
Fax
0539-6222546
Email
2805221329@qq.com
Country
China
ProdList
1474
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shanghai Medicil Biomedical Co., Ltd.
Tel
021-50822001
Email
marketing@medicilon.com.cn
Country
China
ProdList
1152
Advantage
58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
Email
2399235533@qq.com
Country
China
ProdList
4933
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Nanjing Yuanzhi Biotechnology Co. Ltd.
Tel
15805159960
Email
1211550495@qq.com
Country
China
ProdList
1796
Advantage
58
Chengdu Glip Biotechnology Co., Ltd.
Tel
028-87075086 18030859262
Email
2851503756@qq.com
Country
China
ProdList
1928
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11784
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Hubei Ipure Biology Co., Ltd
Tel
+8613367258412
Fax
18062427325
Email
ada@ipurechemical.com
Country
China
ProdList
10237
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Fax
86-28-85159085 Ex:604
Email
info@aktinchem.com
Country
CHINA
ProdList
1025
Advantage
58
Wuhan ChemNorm Biotech Co.,Ltd.
Tel
+86-27-8439 4403 18971486879
Fax
+86-27-8439 4403
Email
sales@chemnorm.com
Country
CHINA
ProdList
2935
Advantage
58
Chengdu Gupte Biotechnology Co., Ltd.
Tel
13881890404
Fax
028-81711798
Email
2851503757@qq.com
Country
China
ProdList
2283
Advantage
58
Shanghai Standard Technology Co., Ltd.
Tel
18502101150
Fax
+86-21-57127007-6606
Email
ft-sales@nature-standard.com
Country
CHINA
ProdList
1923
Advantage
58
Chengdu Alfa Biotechnology Co.,Ltd.
Tel
028-028-85142057 19983342022
Fax
028-85142057
Email
3005359975@qq.com
Country
China
ProdList
1991
Advantage
58
Shanghai jingkang bioengineering co., ltd.
Tel
021-54721350 13524668266
Fax
021-5
Email
2881505714@qq.com
Country
China
ProdList
7872
Advantage
58
More
Less

View Lastest Price from PRUNINDIHYDROCHALCONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PRUNINDIHYDROCHALCONE 4192-90-9
Price
US $1.00-50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-31
Shanghai Standard Technology Co., Ltd.
Product
Trilobatin 4192-90-9
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-05-08
Career Henan Chemical Co
Product
PRUNINDIHYDROCHALCONE 4192-90-9
Price
US $5.50/g
Min. Order
1g
Purity
98%min
Supply Ability
10g,100g,1kg
Release date
2020-01-09

4192-90-9, PRUNINDIHYDROCHALCONERelated Search:

ISOBAVACHALCONE Dihydropashanone Bavachalcone Naringin dihydrochalcone 2'-O-Methylisoliquiritigenin 4,4'-DIHYDROXY-2-METHOXYCHALCONE 4'-Hydroxy-2,4-dimethoxychalcone Hydroxysafflor yellow A NARINGENIN CHALCONE 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Phlorizin Phloretin

  • PRUNINDIHYDROCHALCONE
  • 1-[4-(β-D-Glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
  • Phloretin 4'-glucoside
  • p-Phloridzin
  • p-Phlorizin
  • Trilobatin
  • TRILOBATIN(SH)
  • Trilobatin, 98%, from leaf of strigose hydrangea
  • 1-[2,6-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
  • 1-Propanone, 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • 1-(2,6-Dihydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(4-hydroxyphenyl)propan-1-one
  • trilobin
  • TRILOBATIN(AS) 10mg
  • Trilobatin-RM
  • Trilobatin, 10 mM in DMSO
  • 3,5-dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside
  • 4192-90-9