ChemicalBook > CAS DataBase List > 3-Bromo-1,5-naphthyridine

3-Bromo-1,5-naphthyridine

Product Name
3-Bromo-1,5-naphthyridine
CAS No.
17965-71-8
Chemical Name
3-Bromo-1,5-naphthyridine
Synonyms
3-broMo-1;5-naphthyridine;3-Bromo-1,5phthyridine;3-bromo-1, 5-naphthidine;3-bromo-1,5-naphthyridine;1,5-Naphthyridine,3-bromo-
CBNumber
CB71457099
Molecular Formula
C8H5BrN2
Formula Weight
209.04
MOL File
17965-71-8.mol
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3-Bromo-1,5-naphthyridine Property

Boiling point:
289 °C
Density 
1.656
Flash point:
129 °C
storage temp. 
Sealed in dry,Room Temperature
pka
1.43±0.10(Predicted)
Appearance
Brown to black Solid
InChI
InChI=1S/C8H5BrN2/c9-6-4-8-7(11-5-6)2-1-3-10-8/h1-5H
InChIKey
DQTDPFYKQAQVJU-UHFFFAOYSA-N
SMILES
N1C2C(=NC=CC=2)C=C(Br)C=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB140801
Product name
3-Bromo-1,5-naphthyridine
Packaging
100mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140801
Product name
3-Bromo-1,5-naphthyridine
Packaging
250mg
Price
$140
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140801
Product name
3-Bromo-1,5-naphthyridine
Packaging
500mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
W3903
Product name
3-Bromo-1,5-naphthyridine
Packaging
1g
Price
$261
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140801
Product name
3-Bromo-1,5-naphthyridine
Packaging
1g
Price
$418.75
Updated
2021/12/16
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3-Bromo-1,5-naphthyridine Chemical Properties,Usage,Production

Synthesis

254-79-5

17965-71-8

General procedure for the synthesis of 3-bromo-1,5-naphthyridine from 1,5-naphthyridine: To a 10 mL solution of glacial acetic acid containing compound 4 (2.7 g, 20.76 mmol) and NaOAc (3.41 g, 41.52 mmol), stirred at 85 °C, 1 M of bromine in acetic acid (35 mL) was slowly added, and the reaction lasted for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the acetic acid was removed by vacuum concentration. The product was purified by column chromatography (petroleum ether/ethyl acetate = 2:1) to give compound 5 (2.36 g, 55% yield) as a white solid. Melting point: 107-108 °C (literature value: 108-109 °C).1H NMR (400 MHz, CDCl3): δ 8.96 (d, J = 2.1 Hz, 2H), 8.56 (s, 1H), 8.36 (d, J = 8.5 Hz, 1H), 7.69-7.56 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Patent: WO2011/149937, 2011, A1. Location in patent: Page/Page column 39; 75
[3] Patent: WO2013/78441, 2013, A1. Location in patent: Paragraph 00143; 00305
[4] Patent: WO2008/82487, 2008, A2. Location in patent: Page/Page column 108
[5] Patent: WO2011/15343, 2011, A1. Location in patent: Page/Page column 40

3-Bromo-1,5-naphthyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-1,5-naphthyridine manufacturers

Career Henan Chemical Co
Product
3-Bromo-1,5-naphthyridine 17965-71-8
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-08

17965-71-8, 3-Bromo-1,5-naphthyridineRelated Search:


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