ChemicalBook > CAS DataBase List > 2-Chloro-3-nitro-5-pyridinecarboxylic acid

2-Chloro-3-nitro-5-pyridinecarboxylic acid

Product Name: 2-Chloro-3-nitro-5-pyridinecarboxylic acid
CAS No.: 7477-10-3
Chemical Name: 2-Chloro-3-nitro-5-pyridinecarboxylic acid
Synonyms: 6-Chloro-5-nitronicotinic acid;NSC 404695;6-Chloro-5-Nitro Niacin;6-Chloro-5-nitronicotinicAci;5-Nitro-6-chloronicotinic acid;6-Chloro-5-nitropyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-5-nitro-;6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine;6-Chloro-5-nitronicotinic acid 2 kgs;2-Chloro-3-nitropyridine-5-carboxylic acid, 6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine
CBNumber: CB71457569
Molecular Formula: C6H3ClN2O4
Formula Weight: 202.55
MOL File: 7477-10-3.mol

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2-Chloro-3-nitro-5-pyridinecarboxylic acid Property

Boiling point:: 401.3±45.0 °C(Predicted)
Density: 1.702
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 2.62±0.10(Predicted)
Appearance: Light brown to gray Solid
InChI: InChI=1S/C6H3ClN2O4/c7-5-4(9(12)13)1-3(2-8-5)6(10)11/h1-2H,(H,10,11)
InChIKey: HCRHNMXCDNACMH-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C([N+]([O-])=O)C=C1C(O)=O

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C381103
Product name: 6-Chloro-5-nitronicotinicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C381103
Product name: 6-Chloro-5-nitronicotinicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C381103
Product name: 6-Chloro-5-nitronicotinicacid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-W008886
Product name: 6-Chloro-5-nitro-3-pyridinecarboxylicacid
Purity: 99.63%
Packaging: 10g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC140472
Product name: 6-Chloro-5-nitronicotinic acid
Packaging: 5G
Price: $100
Updated: 2021/12/16

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2-Chloro-3-nitro-5-pyridinecarboxylic acid Chemical Properties,Usage,Production

Uses

2-Chloro-3-nitro-5-pyridinecarboxylic acid is mainly used in organic synthesis and experimental research.

Reactions

2-Chloro-3-nitro-5-pyridinecarboxylic acid is a heterocyclic organic compound characterized by a pyridine ring substituted with a chlorine atom, a nitro group, and a carboxylic acid functional group. The presence of the chlorine atom at the 6-position and the nitro group at the 5-position contributes to its reactivity and potential applications in various chemical syntheses. The carboxylic acid group at the 3-position enhances its solubility in polar solvents and allows for further functionalization.

Synthesis

23056-40-8

7477-10-3

General procedure for the synthesis of 6-chloro-5-nitronicotinic acid from 2-chloro-3-nitro-5-methylpyridine: Sodium dichromate (2.5 g) was slowly added to a mixture of 2-chloro-3-nitro-5-methylpyridine (1.0 g, 6.5 mmol) and concentrated sulfuric acid (27 mL). The reaction mixture was stirred at room temperature for 15 hours and then slowly poured into crushed ice to quench the reaction. The mixture was extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 6-chloro-5-nitronicotinic acid (product) as a green solid (1.0 g, 85% yield).1H NMR (300 MHz, DMSO-d6) δ: 13.32 (s, 1H, carboxylate proton), 8.64 (d, J = 2.4Hz, 1H, pyridine ring proton), 8.37 ( d, J = 2.4Hz, 1H, pyridine ring proton).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 9

2-Chloro-3-nitro-5-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-3-nitro-5-pyridinecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-3-nitro-5-pyridinecarboxylic acid 7477-10-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-11

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 6-Chloro-5-nitronicotinic acid 7477-10-3
Price: US $7.50/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10kg
Release date: 2021-11-26

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 6-Chloro-5-nitronicotinic acid 7477-10-3
Price: US $7.50/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

7477-10-3, 2-Chloro-3-nitro-5-pyridinecarboxylic acidRelated Search:

Ethyl 2-chloronicotinate Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate 2,5-Dichloronicotnic acid 2-Chloro-5-methyl-3-nitropyridine 3-AMINO-2-CHLORO-5-PICOLINE Methyl-6-chloro-5-nitronicotinate 4,6-Dichloro-5-nitronicotinic acid ethyl ester LABOTEST-BB LT01148420 2-Chloro-3-nitro-5-pyridinecarboxylic acid

2-Chloro-3-nitropyridine-5-carboxylic acid, 6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine

6-Chloro-5-nitronicotinic acid 2 kgs

NSC 404695

6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine

6-Chloro-5-nitronicotinic acid

3-Pyridinecarboxylic acid, 6-chloro-5-nitro-

6-Chloro-5-Nitro Niacin

5-Nitro-6-chloronicotinic acid

6-Chloro-5-nitronicotinicAci

6-Chloro-5-nitropyridin-3-carboxylic acid

7477-10-3

blocks

Carboxes

Pyridines