2-Chloro-3-nitro-5-pyridinecarboxylic acid
- Product Name
- 2-Chloro-3-nitro-5-pyridinecarboxylic acid
- CAS No.
- 7477-10-3
- Chemical Name
- 2-Chloro-3-nitro-5-pyridinecarboxylic acid
- Synonyms
- 6-Chloro-5-nitronicotinic acid;NSC 404695;6-Chloro-5-Nitro Niacin;6-Chloro-5-nitronicotinicAci;5-Nitro-6-chloronicotinic acid;6-Chloro-5-nitropyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-5-nitro-;6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine;6-Chloro-5-nitronicotinic acid 2 kgs;2-Chloro-3-nitropyridine-5-carboxylic acid, 6-Chloro-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-chloro-3-nitropyridine
- CBNumber
- CB71457569
- Molecular Formula
- C6H3ClN2O4
- Formula Weight
- 202.55
- MOL File
- 7477-10-3.mol
2-Chloro-3-nitro-5-pyridinecarboxylic acid Property
- Boiling point:
- 401.3±45.0 °C(Predicted)
- Density
- 1.702
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 2.62±0.10(Predicted)
- Appearance
- Light brown to gray Solid
- InChI
- InChI=1S/C6H3ClN2O4/c7-5-4(9(12)13)1-3(2-8-5)6(10)11/h1-2H,(H,10,11)
- InChIKey
- HCRHNMXCDNACMH-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C([N+]([O-])=O)C=C1C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381103
- Product name
- 6-Chloro-5-nitronicotinicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C381103
- Product name
- 6-Chloro-5-nitronicotinicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C381103
- Product name
- 6-Chloro-5-nitronicotinicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-W008886
- Product name
- 6-Chloro-5-nitro-3-pyridinecarboxylicacid
- Purity
- 99.63%
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FC140472
- Product name
- 6-Chloro-5-nitronicotinic acid
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
2-Chloro-3-nitro-5-pyridinecarboxylic acid Chemical Properties,Usage,Production
Uses
2-Chloro-3-nitro-5-pyridinecarboxylic acid is mainly used in organic synthesis and experimental research.
Reactions
2-Chloro-3-nitro-5-pyridinecarboxylic acid is a heterocyclic organic compound characterized by a pyridine ring substituted with a chlorine atom, a nitro group, and a carboxylic acid functional group. The presence of the chlorine atom at the 6-position and the nitro group at the 5-position contributes to its reactivity and potential applications in various chemical syntheses. The carboxylic acid group at the 3-position enhances its solubility in polar solvents and allows for further functionalization.
Synthesis
23056-40-8
7477-10-3
General procedure for the synthesis of 6-chloro-5-nitronicotinic acid from 2-chloro-3-nitro-5-methylpyridine: Sodium dichromate (2.5 g) was slowly added to a mixture of 2-chloro-3-nitro-5-methylpyridine (1.0 g, 6.5 mmol) and concentrated sulfuric acid (27 mL). The reaction mixture was stirred at room temperature for 15 hours and then slowly poured into crushed ice to quench the reaction. The mixture was extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 6-chloro-5-nitronicotinic acid (product) as a green solid (1.0 g, 85% yield).1H NMR (300 MHz, DMSO-d6) δ: 13.32 (s, 1H, carboxylate proton), 8.64 (d, J = 2.4Hz, 1H, pyridine ring proton), 8.37 ( d, J = 2.4Hz, 1H, pyridine ring proton).
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 9
2-Chloro-3-nitro-5-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-nitro-5-pyridinecarboxylic acid Suppliers
- Tel
- --
- Fax
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- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from 2-Chloro-3-nitro-5-pyridinecarboxylic acid manufacturers
- Product
- 2-Chloro-3-nitro-5-pyridinecarboxylic acid 7477-10-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-11
- Product
- 6-Chloro-5-nitronicotinic acid 7477-10-3
- Price
- US $7.50/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10kg
- Release date
- 2021-11-26
- Product
- 6-Chloro-5-nitronicotinic acid 7477-10-3
- Price
- US $7.50/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-11-26