2-Chloro-5-methyl-3-nitropyridine

Application

Product Name: 2-Chloro-5-methyl-3-nitropyridine
CAS No.: 23056-40-8
Chemical Name: 2-Chloro-5-methyl-3-nitropyridine
Synonyms: 6-CHLORO-5-NITRO-3-PICOLINE;2-CHLORO-3-NITRO-5-PICOLINE;2-Chloro-3-nitro-5-picoline,98%;2-chloro-5-methyl-3-nitropyridne;2-CHLORO-3-NITRO-5-METHYLPYRIDINE;2-CHLORO-5-METHYL-3-NITROPYRIDINE;2-Chloro-5-methyl-3-nitropyrinedi;2-Chloro-5-metnyl-3-nitropyridine;Pyridine, 2-chloro-5-Methyl-3-nitro-;2-Chloro-5-methyl-3-nitropyridine 97%
CBNumber: CB9319455
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 23056-40-8.mol

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2-Chloro-5-methyl-3-nitropyridine Property

Melting point:: 45-50 °C
Boiling point:: 290.8±35.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: -2.20±0.10(Predicted)
color: White to Orange to Green
Sensitive: Hygroscopic
BRN: 138198
CAS DataBase Reference: 23056-40-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-21/22-41-37/38-22
Safety Statements: 36/37/39-26-36-39
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 705918
Product name: 2-Chloro-5-methyl-3-nitropyridine
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2023/06/20

Sigma-Aldrich

Product number: 705918
Product name: 2-Chloro-5-methyl-3-nitropyridine
Purity: 97%
Packaging: 1g
Price: $64.4
Updated: 2023/01/07

TCI Chemical

Product number: C2022
Product name: 2-Chloro-5-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: C2022
Product name: 2-Chloro-5-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $118
Updated: 2025/07/31

TRC

Product number: C993775
Product name: 2-Chloro-5-methyl-3-nitropyridine
Packaging: 10g
Price: $90
Updated: 2021/12/16

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2-Chloro-5-methyl-3-nitropyridine Chemical Properties,Usage,Production

Application

2-Chloro-5-methyl-3-nitropyridine is an organic intermediate that can be obtained by chlorination of 5-methyl-3-nitropyridine-2(1H)-one. The chlorination reagent can be selected from phosphorus oxychloride. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.

Chemical Properties

Beige powder

Synthesis

7464-14-4

23056-40-8

a) General procedure for the synthesis of 2-chloro-5-methyl-3-nitropyridine: 5-methyl-3-nitropyridin-2-ol (5 g, 32.4 mmol) and benzyltrimethylammonium chloride (3.01 g, 16.2 mmol) were dissolved in acetonitrile, followed by addition of phosphorochloridic acid (9.0 ml, 97.2 mmol). The reaction mixture was stirred at 80 °C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to quench the reaction. The aqueous phase was extracted with dichloromethane and the organic layers were combined, washed with saturated brine solution and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent. The fraction containing the target compound was collected and concentrated under reduced pressure to give 2-chloro-5-methyl-3-nitropyridine as a yellow solid (5.39 g, 97% yield). The product was confirmed by 1H-NMR (CDCl3, 300 MHz) and mass spectrometry (ESI): 1H-NMR δ= 8.45 (d, 1H, J = 2.3Hz), 8.04 (d, 1H, J = 2.3Hz), 2.46 (s, 3H); MS (ESI) m/z: 173.0 ([M+H]+).

References

[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 51
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[3] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 9
[4] Patent: WO2015/73528, 2015, A1. Location in patent: Page/Page column 118
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 3504

2-Chloro-5-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Calcium oxide Phosphorus oxitrichloride Sodium nitrite Diethyl ether Nitric acid Sodium hydroxide Sulfuric acid

Preparation Products

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2-Chloro-5-methyl-3-nitropyridine Suppliers

Americas 1 Belgium 1 China 200 Europe 1 France 3 Germany 3 India 35 Japan 1 Jordan 1 The Netherlands 1 United Kingdom 8 United States 38 Global 293

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View Lastest Price from 2-Chloro-5-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-5-methyl-3-nitropyridine 23056-40-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-5-methyl-3-nitropyridine 23056-40-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 2-Chloro-3-nitro-5-picoline 23056-40-8
Price: US $14.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 21
Release date: 2022-01-12

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23056-40-8

Chloropyridines

Halopyridines

pyridine series

Building Blocks

C5 to C6

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Chloropyridines

Halopyridines

blocks

NitroCompounds

Pyridines

Pyridine

C6