ChemicalBook > CAS DataBase List > 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

Product Name: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
CAS No.: 878671-96-6
Chemical Name: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
Synonyms: 2,3-Butanedione,4-bromo-;3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-napht...;3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol;3-Amino-4-(4-cyclopropyl-1-naphthyl)-1H-1,2,4-triazole-5(4H)-thione;3-amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5-thione;5-AMINO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-2H-1,2,4-TRIAZOLE-3-THIONE;3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione;3-amino-4 - (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5-thione;3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-phthalenyl)-2,4-dihydro;5-amino-4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CBNumber: CB71465755
Molecular Formula: C15H14N4S
Formula Weight: 282.36
MOL File: 878671-96-6.mol

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3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Property

Boiling point:: 475.2±38.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 8.22±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A602180
Product name: 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
Packaging: 25g
Price: $525
Updated: 2021/12/16

AK Scientific

Product number: 4000AC
Product name: 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
Packaging: 5g
Price: $455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0098434
Product name: 3H-1,2,4-TRIAZOLE-3-THIONE, 5-AMINO-4-(4-CYCLOPROPYL-1-NAPHTHALENYL)-2,4-DIHYDRO
Purity: 95.00%
Packaging: 1G
Price: $1210.32
Updated: 2021/12/16

AK Scientific

Product number: 4000AC
Product name: 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
Packaging: 1g
Price: $185
Updated: 2021/12/16

Chemenu

Product number: CM119266
Product name: 3-Amino-4-(4-cyclopropyl-1-naphthyl)-1H-1,2,4-triazole-5(4H)-thione
Purity: 95%
Packaging: 5g
Price: $281
Updated: 2021/12/16

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3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Chemical Properties,Usage,Production

Uses

5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol is a derivative of 5-Amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-Triazol-3-one (A602165), which is an impurity of the drug Lesinuard (L329700), which is used to synthesize febuxostat, a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.

Synthesis

878671-95-5

1937-19-5

878671-96-6

1-Cyclopropyl-4-isothiocyanato naphthalene (13.3 mmol, 3.0 g) and aminoguanidine hydrochloride (26.6 mmol, 2.9 g) were mixed in 50 mL of N,N-dimethylformamide. N,N-diisopropylethylamine (39.9 mmol, 5.1 g) was slowly added under stirring conditions. The reaction mixture was stirred at room temperature for 50±12 hrs. After completion of the reaction, the solvent was removed to dryness by rotary evaporator. To the residue, 20 mL of 2 M sodium hydroxide solution was added and the reaction was continued for 50 ± 12 hours. After termination of the reaction, the reaction mixture was filtered and the filtrate was adjusted to pH=4 with dilute hydrochloric acid, at which time a large amount of white precipitate was observed to be generated. The precipitate was collected, washed with deionized water and subsequently dried under vacuum at 45-50 °C to afford the intermediate compound 5-amino-4-(4-cyclopropyl-1-naphthalene)-2,4-dihydro-3H-1,2,4-triazole-3-thiol (VI) in 2.85 g yield and 76% yield.

References

[1] Patent: CN105566237, 2016, A. Location in patent: Paragraph 0066; 0067; 0068
[2] Patent: WO2009/70740, 2009, A2. Location in patent: Page/Page column 89-90
[3] Patent: WO2006/26356, 2006, A2. Location in patent: Page/Page column 21
[4] Patent: WO2011/85009, 2011, A2. Location in patent: Page/Page column 37

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 878671-96-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 878671-96-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 878671-96-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

878671-96-6, 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydroRelated Search:

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

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3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-phthalenyl)-2,4-dihydro

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3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-napht...

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878671-96-6

878971-96-6

Drug Intermediates