5-Bromo-2-methyl-3-nitropyridine

Product Name: 5-Bromo-2-methyl-3-nitropyridine
CAS No.: 911434-05-4
Chemical Name: 5-Bromo-2-methyl-3-nitropyridine
Synonyms: 5-broMo-2-Methyl-3-n;5-Bromo-3-nitropicoline;5-Bromo-3-nitro-2-picoline;5-Bromo-2-methyl-3-nitrop...;5-bromo-2-methy-3-nitropyridine;5-Bromo-2-methyl-3-nitropyridine;5-Bromo-2-methy1-3-nitropyridine;2-methyl-3-nitro-5-bromo pyridine;Pyridine,5-broMo-2-Methyl-3-nitro-;5-Bromo-2-methyl-3-nitropyridine >
CBNumber: CB71471280
Molecular Formula: C6H5BrN2O2
Formula Weight: 217.02
MOL File: 911434-05-4.mol

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5-Bromo-2-methyl-3-nitropyridine Property

Melting point:: 38.0 to 42.0 °C
Boiling point:: 253 °C
Density: 1.709
Flash point:: 107 °C
storage temp.: Inert atmosphere,Room Temperature
pka: -0.44±0.20(Predicted)
form: powder to crystal
color: Light yellow to Amber to Dark green
InChI: InChI=1S/C6H5BrN2O2/c1-4-6(9(10)11)2-5(7)3-8-4/h2-3H,1H3
InChIKey: FZZLWWNOYMHSIS-UHFFFAOYSA-N
SMILES: C1(C)=NC=C(Br)C=C1[N+]([O-])=O

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4070
Product name: 5-Bromo-2-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: B4070
Product name: 5-Bromo-2-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TRC

Product number: B688430
Product name: 5-Bromo-2-methyl-3-nitropyridine
Packaging: 10g
Price: $250
Updated: 2021/12/16

Oakwood

Product number: 049683
Product name: 5-Bromo-2-methyl-3-nitropyridine
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 067245
Product name: 5-Bromo-2-methyl-3-nitropyridine
Purity: 98%
Packaging: 5g
Price: $19
Updated: 2021/12/16

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5-Bromo-2-methyl-3-nitropyridine Chemical Properties,Usage,Production

Uses

5-Bromo-2-methyl-3-nitropyridine is used as a reactant in the synthesis of MLN0905, a potent and orally bioavailable inhibitor of Polo-like kinase 1 (PLK1).

Synthesis

911434-04-3

911434-05-4

Step 2 - Synthesis of 5-bromo-2-methyl-3-nitropyridine Diethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate (1.2 g, 3.3 mmol) was dissolved in 7.0 N HCl (10 mL). The mixture was heated to reflux for 5 hours. After completion of the reaction, it was cooled to room temperature and extracted with dichloromethane: methanol (10:1, v/v). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by column chromatography using petroleum ether: ethyl acetate (4:1, v/v) as eluent to afford 5-bromo-2-methyl-3-nitropyridine (0.7 g, yield: 89.7%). 1H-NMR (CDCl3, 400 MHz) δ 8.76 (s, 1H), 8.40 (s, 1H), 2.80 (s, 3H).

References

[1] Patent: US2008/194552, 2008, A1. Location in patent: Page/Page column 40
[2] Patent: WO2010/68292, 2010, A1. Location in patent: Page/Page column 78
[3] Patent: WO2013/33899, 2013, A1. Location in patent: Page/Page column 39
[4] Patent: WO2013/34048, 2013, A1. Location in patent: Page/Page column 46; 47
[5] Patent: WO2012/88411, 2012, A1. Location in patent: Page/Page column 64

5-Bromo-2-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-methyl-3-nitropyridine Suppliers

Americas 1 China 241 Europe 1 France 1 Germany 1 India 11 Japan 1 United Kingdom 2 United States 15 Global 274

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View Lastest Price from 5-Bromo-2-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2-methyl-3-nitropyridine 911434-05-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Bromo-2-methyl-3-nitropyridine 911434-05-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-23

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-methyl-3-nitropyridine 911434-05-4
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 50tons
Release date: 2020-05-12

911434-05-4, 5-Bromo-2-methyl-3-nitropyridineRelated Search:

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Heterocycle-Pyridine series