ChemicalBook > CAS DataBase List > (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol

(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol

Product Name
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
CAS No.
289893-25-0
Chemical Name
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
Synonyms
Pefcalcitol;Amrioclomol;arimoclomol;(2R-)Arimoclomol;BRX-220 free base;(2R-)Arimoclomol NEW;Arimoclomol, 10 mM in DMSO;(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol;3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide;aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor
CBNumber
CB71480024
Molecular Formula
C14H20ClN3O3
Formula Weight
313.78
MOL File
289893-25-0.mol
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(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Property

Melting point:
93 - 95o C
Boiling point:
539.2±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
14.03±0.20(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H261In contact with water releases flammable gas

Precautionary statements

P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.

P231+P232Handle under inert gas. Protect from moisture.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P335+P334Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.

P370+P378In case of fire: Use … for extinction.

P402+P404Store in a dry place. Store in a closed container.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A771278
Product name
Arimoclomol
Packaging
1mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30834
Product name
(2R-)Arimoclomol NEW
Packaging
1mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30834
Product name
(2R-)Arimoclomol NEW
Packaging
2mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30834
Product name
(2R-)Arimoclomol NEW
Packaging
5mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30834
Product name
(2R-)Arimoclomol NEW
Packaging
10mg
Price
$300
Updated
2021/12/16
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(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Chemical Properties,Usage,Production

Uses

Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.

in vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

Animal Model:Male Wistar rats weighing 240 to 270 g[1]
Dosage:20 mg/kg
Administration:Administered intragastrically, for 5 days
Result:Had a protective effect against CCK-induced acute pancreatitis.

IC 50

HSP

(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Suppliers

China 37 India 2 United Kingdom 1 United States 6 Global 46
BOC Sciences
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marketing@targetmol.com
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289893-25-0, (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-olRelated Search:

Aprepitant

  • (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
  • arimoclomol
  • Amrioclomol
  • Pefcalcitol
  • (2R-)Arimoclomol NEW
  • BRX-220 free base
  • 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide
  • aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor
  • Arimoclomol, 10 mM in DMSO
  • (2R-)Arimoclomol
  • 289893-25-0