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(S)-ROSCOVITINE

Product Name
(S)-ROSCOVITINE
CAS No.
186692-45-5
Chemical Name
(S)-ROSCOVITINE
Synonyms
Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem;(2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol;1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)-
CBNumber
CB71498962
Molecular Formula
C19H26N6O
Formula Weight
354.45
MOL File
186692-45-5.mol
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(S)-ROSCOVITINE Property

Melting point:
103-106℃
Density 
1.25
storage temp. 
-20C
form 
White solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
AG-MR-C0002-M005
Product name
(S)-Roscovitine
Purity
≥99%(NMR)
Packaging
5mg
Price
$90
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000007
Product name
(S)-ROSCOVITINE
Purity
95.00%
Packaging
1MG
Price
$456
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000007
Product name
(S)-ROSCOVITINE
Purity
95.00%
Packaging
5MG
Price
$802.38
Updated
2021/12/16
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(S)-ROSCOVITINE Chemical Properties,Usage,Production

Uses

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].

in vivo

(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) shows neuroprotective efficacy in an adult mouse model of permanent MCAo (middle cerebral artery occlusion) [2].

Animal Model:20-25 g, P60 male C57 b/6 mice[2]
Dosage:25 mg/kg
Administration:I.p.; at 15 min before and 1 hr after pMCAo
Result:Decreased of the total infarct volume.

IC 50

CDK1: ≤1 μM (IC50); CDK2: ≤1 μM (IC50); CDK5: ≤1 μM (IC50); CDK7: ≤1 μM (IC50); CDK9: ≤1 μM (IC50)

storage

+4°C

References

[1] Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. DOI:10.3390/cells10010104
[2] Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117. DOI:10.1371/journal.pone.0012117

(S)-ROSCOVITINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-ROSCOVITINE Suppliers

China 6 India 1 United Kingdom 1 United States 2 Global 10
Glentham Life Sciences
Tel
--
Fax
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Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
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186692-45-5, (S)-ROSCOVITINERelated Search:

OLOMOUCINE N9-ISOPROPYL-OLOMOUCINE Ro 3306 NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II AMINOPURVALANOL A SU 9516 NU6102 Roscovitine (S)-ROSCOVITINE

  • (2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
  • Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)-
  • 186692-45-5
  • C19H26N6O