Mizolastine
Abstract Medical efficacy Precautions References- Product Name
- Mizolastine
- CAS No.
- 108612-45-9
- Chemical Name
- Mizolastine
- Synonyms
- MKC 431;Mizollen;Zolistan;MistaMine;SL 850324;Mizostatin;MIZOLASTINE;Mizolastine>Mizolastine HCl;Mizolastine inn
- CBNumber
- CB7150058
- Molecular Formula
- C24H25FN6O
- Formula Weight
- 432.49
- MOL File
- 108612-45-9.mol
Mizolastine Property
- Melting point:
- 217°
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly, Heated), DMSO, Methanol (Slightly, Heated)
- form
- Solid
- pka
- 9.73±0.40(Predicted)
- color
- White
- Merck
- 14,6221
Safety
- RTECS
- UW7481284
- HS Code
- 2933.39.9200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M2756
- Product name
- Mizolastine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $119
- Updated
- 2024/03/01
- Product number
- M2756
- Product name
- Mizolastine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $469
- Updated
- 2024/03/01
- Product number
- M385400
- Product name
- Mizolastine
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 094171
- Product name
- 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- CS-1997
- Product name
- Mizolastine
- Purity
- 99.33%
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
Mizolastine Chemical Properties,Usage,Production
Abstract
Mizolastine (Mizollen) is a non-sedating antihistamine. It blocks H1 receptors and is commonly fast-acting. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors.
Medical efficacy
Mizolastine is a second generation antihistamine agent with high affinity and specificity for histamine H(1) receptors. Mizolastine has demonstrated antiallergic effects in animals and healthy volunteers and anti-inflammatory activity in animal models. Double-blind trials
have shown mizolastine to be significantly more effective than placebo and as effective as other second generation antihistamine agents, such as loratadine or cetirizine, in the management of patients with perennial or seasonal allergic rhinitis and in patients with
chronic idiopathic urticaria.
It not only has a strong anti-histamine but also has inflammatory neurotransmitters inhibit action, such as inhibit the generation of leukotrienes, reduce edema. Thus in theory, mizolastine has both anti-histamine and anti-allergic effects. The role of anti-inflammatory activity, for the treatment of acute urticaria preferred drug, significantly the onset of action is faster than other antihistamines, and the medication can reduce the number of the wheal hours after 1-3 hours, itching abated, and maintain a long time, up to 24 hours.
At present, the clinical treatment is mainly used for the treatment of adults or children over 12 years of age suffering from urticaria and other skin allergy symptoms, seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis.
Precautions
Don't take this medicine in these conditions:
- If you are pregnant or breast-feeding.
- If you have any problems with the way your liver works.
- If you have a heart condition or an abnormal heart rhythm.
- If you have epilepsy.
- If you have a rare inherited blood disorder called porphyria.
- If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
- If you have ever had an allergic reaction to another antihistamine, or to any other medicine.
References
http://patient.info/medicine/mizolastine-tablets-mizollen
https://en.wikipedia.org/wiki/Mizolastine
https://www.ncbi.nlm.nih.gov/pubmed/18020585
Description
Mizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzimidazole by successive condensations of appropriate amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors (but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal occupancy of brain receptors, and therefore does not elicit any sedative effects. Moreover, Mizolastine does not produce cardiac rhythm disorders which have been associated with certain non-sedating antihistamines in humans.
Chemical Properties
White Solid
Originator
Synthelabo (France)
Uses
A highly selective histamine H1-receptor antagonist (with no anticholinergic, antiadrenergic, or antiserotonin activity) for use in the treatment of allergic disorders, especially rhinitis and urticaria.
Uses
Allergic rhinitis;Blocking H1 receptors
Definition
ChEBI: Mizolastine is a member of benzimidazoles.
brand name
Mizollen
Clinical Use
Antihistamine:
Symptomatic relief of allergy, e.g. hayfever, urticaria
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of ventricular
arrhythmias - avoid with amiodarone, disopyramide,
flecainide, mexiletine, procainamide and
propafenone.
Antibacterials: metabolism possibly inhibited by
macrolides - avoid; increased risk of ventricular
arrhythmias with moxifloxacin - avoid.
Antidepressants: risk of ventricular arrhythmias with
citalopram and escitalopram - avoid.
Antifungals: metabolism inhibited by itraconazole
and ketoconazole and possibly imidazoles - avoid.
Antimalarials: avoid with piperaquine with
artenimol.
Antivirals: concentration possibly increased by
ritonavir; increased risk of ventricular arrhythmias
with saquinavir - avoid.
Beta-blockers: increased risk of ventricular
arrhythmias with sotalol - avoid.
Ciclosporin: use with caution due to inhibition of
ciclosporin metabolism.
Cytotoxics: possible increased risk of ventricular
arrhythmias with vandetanib.
Avoid concomitant treatment with any drug that
could prolong QT interval.
Caution with drugs that inhibit cytochrome P450
enzymes (may elevate mizolastine levels)
Metabolism
Mainly metabolised by glucuronidation although other metabolic pathways are involved, including metabolism by the cytochrome P450 isoenzyme CYP3A4, with the formation of inactive hydroxylated metabolites
Mizolastine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mizolastine manufacturers
- Product
- Mizolastine 108612-45-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0 ~ 102%
- Supply Ability
- 20tons
- Release date
- 2023-09-21
- Product
- Mizolastine 108612-45-9
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-02
- Product
- Mizolastine 108612-45-9
- Price
- US $1000.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-09-15