2-phenyldihydro-2H-pyran-4(3H)-one
- Product Name
- 2-phenyldihydro-2H-pyran-4(3H)-one
- CAS No.
- 147688-62-8
- Chemical Name
- 2-phenyldihydro-2H-pyran-4(3H)-one
- Synonyms
- 2-phenyltetrahydropyran-4-one;2-(1-cyclohex-2-enyl)-4-pyranone;2-phenyltetrahydro-4H-pyran-4-one;2-phenyldihydro-2H-pyran-4(3H)-one;Tetrahydro-2-phenyl-4H-pyran-4-one;4H-Pyran-4-one,tetrahydro-2-phenyl-;2-phenyltetrahydropyran-4-one - [P83046]
- CBNumber
- CB71504502
- Molecular Formula
- C11H12O2
- Formula Weight
- 176.21
- MOL File
- 147688-62-8.mol
2-phenyldihydro-2H-pyran-4(3H)-one Property
- Boiling point:
- 306 °C
- Density
- 1.113
- refractive index
- 1.5410
- Flash point:
- 141 °C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P319893
- Product name
- 2-Phenyldihydro-2H-pyran-4(3H)-one
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 074032
- Product name
- 2-Phenyldihydro-2H-pyran-4(3H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- AS16069
- Product name
- 2-Phenyldihydro-2H-pyran-4(3H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- W3222
- Product name
- 2-Phenyldihydro-2H-pyran-4(3H)-one
- Packaging
- 5g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CHM0388577
- Product name
- 2-PHENYLDIHYDRO-2H-PYRAN-4(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.36
- Updated
- 2021/12/16
2-phenyldihydro-2H-pyran-4(3H)-one Chemical Properties,Usage,Production
Synthesis
82065-19-8
147688-62-8
General procedure for the synthesis of tetrahydro-2-phenyl-4H-pyran-4-one from 2-phenyltetrahydro-2H-pyran-4-ol: A DMSO solution of 2-phenyltetrahydro-2H-pyran-4-one (615 mmol) was added slowly and dropwise to a solution of oxaloyl chloride (128 mmol) in dichloromethane (100 mL) at -78 °C. The reaction mixture was stirred at -78°C for 15 minutes before a solution of 2-phenyltetrahydro-2H-pyran-4-ol (84 mmol) in dichloromethane (50 mL) was slowly added. Stirring was continued at -78 °C for 30 min, followed by the slow addition of N,N-diisopropylethylamine (DIPEA, 78 mL) and the reaction mixture was continued to be stirred at the same temperature for 3 hours. Upon completion of the reaction, water (100 mL) and dichloromethane (200 mL) were added and stirred for 15 minutes at room temperature. The organic layer was separated and the aqueous layer was extracted twice with dichloromethane. The organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a petroleum ether solution of 50% ethyl acetate as eluent to afford the target product tetrahydro-2-phenyl-4H-pyran-4-one in 72% yield.1H NMR (D6-DMSO): δ 2.44 (1H, d), 2.65 (1H, m), 2.66 (1H, t), 2.74 (1H, m), 3.85 (1H , dt), 4.44 (1H, m), 4.65 (1H, dd), 7.40-7.30 (m, 5H).
References
[1] Journal of the American Chemical Society, 1982, vol. 104, # 17, p. 4666 - 4671
[2] Patent: WO2009/124882, 2009, A1. Location in patent: Page/Page column 36
[3] Chemische Berichte, 1955, vol. 88, p. 1053,1059
[4] Bulletin de la Societe Chimique de France, 1954, p. 534
2-phenyldihydro-2H-pyran-4(3H)-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-phenyldihydro-2H-pyran-4(3H)-one manufacturers
- Product
- 2-phenyldihydro-2H-pyran-4(3H)-one 147688-62-8
- Price
- US $25.00/g
- Min. Order
- 1g
- Purity
- 99.96%
- Supply Ability
- 500ton
- Release date
- 2023-06-14