5-bromo-2-(trifluoromethyl)pyrimidine

Product Name: 5-bromo-2-(trifluoromethyl)pyrimidine
CAS No.: 799557-86-1
Chemical Name: 5-bromo-2-(trifluoromethyl)pyrimidine
Synonyms: EOS-62113;5-Bromo-2-(trifluoromethyl)pyrimidine;5-Bromo-2-(trifluoromethyl)-1,3-diazine;Pyrimidine, 5-bromo-2-(trifluoromethyl)-;5-Bromo-2-(trifluoromethyl)pyrimidine,95%;5-Bromo-2-(trifluoromethyl)pyrimidine 96%;5-Bromo-2-(trifluoromethyl)pyrimidine, tech;5-bromo-2-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH
CBNumber: CB71512778
Molecular Formula: C5H2BrF3N2
Formula Weight: 226.98
MOL File: 799557-86-1.mol

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5-bromo-2-(trifluoromethyl)pyrimidine Property

Melting point:: 41-42°
Boiling point:: 139.8±40.0 °C(Predicted)
Density: 1.807±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.28±0.22(Predicted)
form: Crystalline
color: White
InChI: InChI=1S/C5H2BrF3N2/c6-3-1-10-4(11-2-3)5(7,8)9/h1-2H
InChIKey: GIFDWXWNFKZVEI-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=C(Br)C=N1

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B688380
Product name: 5-Bromo-2-trifluoromethylpyrimidine
Packaging: 500mg
Price: $165
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0098871
Product name: 5-BROMO-2-(TRIFLUOROMETHYL)PYRIMIDINE
Purity: 95.00%
Packaging: 500MG
Price: $932.89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0098871
Product name: 5-BROMO-2-(TRIFLUOROMETHYL)PYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $941.33
Updated: 2021/12/16

Matrix Scientific

Product number: 046129
Product name: 5-Bromo-2-(trifluoromethyl)pyrimidine
Purity: 95+%
Packaging: 500mg
Price: $57
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP74722
Product name: 5-Bromo-2-(trifluoromethyl)pyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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5-bromo-2-(trifluoromethyl)pyrimidine Chemical Properties,Usage,Production

Uses

5-bromo-2-(trifluoromethyl)pyrimidine was used in the preparation of pyrimidinone compounds as Lp-PLA2 inhibitors.

Synthesis

116470-67-8

799557-86-1

General procedure for the synthesis of 5-bromo-2-trifluoromethylpyrimidine using 2-trifluoromethylpyrimidine as starting material: 24 g of 2-trifluoromethylpyrimidine was dissolved in 200 ml of acetic acid and 50 g of bromine was added slowly and dropwise. The reaction mixture was heated to reflux and kept reacting overnight. After completion of the reaction, it was cooled to room temperature and extracted by adding appropriate amount of water and ethyl acetate. The organic and aqueous phases were separated and the organic phase was collected. The organic phase was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 29 g of 5-bromo-2-trifluoromethylpyrimidine.

References

[1] Patent: CN108129456, 2018, A. Location in patent: Paragraph 0020; 0021-0022
[2] Patent: CN108218792, 2018, A. Location in patent: Paragraph 0020; 0021; 0022

5-bromo-2-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-2-(trifluoromethyl)pyrimidine Suppliers

Canada 1 China 159 India 2 United Kingdom 2 United States 10 Global 174

Shanghai TBBMed Co.,Ltd

Tel: 021-50498136 13564881053
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Alfa Aesar

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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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Changzhou Huanling Chemical Co., Ltd.

Tel: 0519-89803565 13776850645
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Shangchem Co., Ltd.

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View Lastest Price from 5-bromo-2-(trifluoromethyl)pyrimidine manufacturers

Dideu Industries Group Limited

Product: 5-bromo-2-(trifluoromethyl)pyrimidine 799557-86-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-07

Career Henan Chemical Co

Product: 5-bromo-2-(trifluoromethyl)pyrimidine 799557-86-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

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