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2-Trifluoromethyl-5-bromopyridine

Product Name
2-Trifluoromethyl-5-bromopyridine
CAS No.
436799-32-5
Chemical Name
2-Trifluoromethyl-5-bromopyridine
Synonyms
5-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE;C6H3BrF3N=M 225.99;TRIFLUOROMETHYL-5-BROMOPYRIDINE;2-TRIFLUOROMETHYL-5-BROMOPYRIDINE;TRIFLUOROMETHYL-5-BROMO-2-PYRIDINE;3-Bromo-6-(trifluoromethyl) pyridine;5-Bromo-2-(trifluoromethyl)pyridine97%;Pyridine, 5-bromo-2-(trifluoromethyl)-;5-Bromo-2-(trifluoromethyl)pyridine >5-Bromo-2-(trifluoromethyl)pyridine 97%
CBNumber
CB8188333
Molecular Formula
C6H3BrF3N
Formula Weight
225.99
MOL File
436799-32-5.mol
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2-Trifluoromethyl-5-bromopyridine Property

Melting point:
44-46 °C
Boiling point:
68-70°C 10mm
Density 
1.707±0.06 g/cm3(Predicted)
Flash point:
174 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
-1.80±0.22(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H3BrF3N/c7-4-1-2-5(11-3-4)6(8,9)10/h1-3H
InChIKey
RPFAUCIXZGMCFN-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=C(Br)C=C1
CAS DataBase Reference
436799-32-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-37-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
661104
Product name
5-Bromo-2-(trifluoromethyl)pyridine
Purity
97%
Packaging
500mg
Price
$88.8
Updated
2023/06/20
Sigma-Aldrich
Product number
661104
Product name
5-Bromo-2-(trifluoromethyl)pyridine
Purity
97%
Packaging
5g
Price
$133
Updated
2023/06/20
TCI Chemical
Product number
B3451
Product name
5-Bromo-2-(trifluoromethyl)pyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
B3451
Product name
5-Bromo-2-(trifluoromethyl)pyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$111
Updated
2025/07/31
TRC
Product number
B699018
Product name
5-Bromo-2-trifluoromethylpyridine
Packaging
500mg
Price
$65
Updated
2021/12/16
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2-Trifluoromethyl-5-bromopyridine Chemical Properties,Usage,Production

Chemical Properties

white crystal powder

Uses

Regioselective C-4 deprotonation with LDA and trapping with carbon dioxide leads to the corresponding C-4 acid.

Synthesis

624-28-2

680-15-9

436799-32-5

Step 1: Synthesis of 5-bromo-2-(trifluoromethyl)pyridine To a stirred solution of 2,5-dibromopyridine (0.1 g, 0.421 mmol) in DMF (5.0 mL) was sequentially added methyl fluorosulfonyl difluoroacetate (0.405 g, 2.109 mmol) and cuprous iodide (0.401 g, 2.109 mmol). The reaction mixture was stirred at 100 °C for 12 h and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the crude product 5-bromo-2-(trifluoromethyl)pyridine (0.07 g, 73% yield) as a light yellow oil, which could be used in subsequent steps without further purification. Mass spectrum (MS): 227.28 [M++1].

References

[1] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0577-0579
[2] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0445-0447

2-Trifluoromethyl-5-bromopyridine Preparation Products And Raw materials

Raw materials

(Trifluoromethyl)trimethylsilane N-Methyl-2-pyrrolidone Cuprous iodide Potassium fluoride Diethyl ether 2,5-Dibromopyridine Ammonia

Preparation Products

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2-Trifluoromethyl-5-bromopyridine Suppliers

Americas 1 Belgium 2 Canada 1 China 297 Czech Republic 1 Europe 1 Germany 6 India 8 Ireland 1 Italy 1 Japan 3 Switzerland 3 United Kingdom 16 United States 45 Global 386
Changzhou Yanji Biotechnology Co., Ltd.
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0519-83556355 18015005120
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shikewei397@163.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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future industrial shanghai co., ltd
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400-0066400 13621662912
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021-55660885
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sales@jonln.com
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China
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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Sales-CN@TCIchemicals.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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86-027-87531808
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sales@chemwish.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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View Lastest Price from 2-Trifluoromethyl-5-bromopyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Trifluoromethyl-5-bromopyridine 436799-32-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Dideu Industries Group Limited
Product
2-Trifluoromethyl-5-bromopyridine 436799-32-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Trifluoromethyl-5-bromopyridine 436799-32-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

436799-32-5, 2-Trifluoromethyl-5-bromopyridineRelated Search:

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  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Fluorine series
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Heterocyclic Compounds
  • Heterocycle
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridine
  • blocks
  • Bromides
  • FluoroCompounds
  • Pyridines
  • Pyridine Series
  • Halides
  • Heterocycles
  • 436799-32-5