6-bromo-4-chlorocinnoline
- Product Name
- 6-bromo-4-chlorocinnoline
- CAS No.
- 68211-15-4
- Chemical Name
- 6-bromo-4-chlorocinnoline
- Synonyms
- 6-bromo-4-chlorocinnoline;Cinnoline, 6-broMo-4-chloro-;6-bromo-4-chlorocinnoline - [B24879]
- CBNumber
- CB71518725
- Molecular Formula
- C8H4BrClN2
- Formula Weight
- 243.49
- MOL File
- 68211-15-4.mol
6-bromo-4-chlorocinnoline Property
- Melting point:
- 127-128℃
- Boiling point:
- 359.6±45.0 °C(Predicted)
- Density
- 1.762
- storage temp.
- Storage temp. -20°C
- pka
- -1.08±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
- InChI
- InChI=1S/C8H4BrClN2/c9-5-1-2-8-6(3-5)7(10)4-11-12-8/h1-4H
- InChIKey
- WAKDQKOZUBTOEX-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(Br)C=C2)=C(Cl)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 0513AC
- Product name
- 6-Bromo-4-chlorocinnoline
- Packaging
- 250mg
- Price
- $451
- Updated
- 2021/12/16
- Product number
- HCH0359724
- Product name
- 6-BROMO-4-CHLOROCINNOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.66
- Updated
- 2021/12/16
- Product number
- 143708
- Product name
- 6-Bromo-4-chlorocinnoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $903
- Updated
- 2021/12/16
- Product number
- 143708
- Product name
- 6-Bromo-4-chlorocinnoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $2709
- Updated
- 2021/12/16
- Product number
- A263952
- Product name
- 6-Bromo-4-chlorocinnoline
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $56
- Updated
- 2021/12/16
6-bromo-4-chlorocinnoline Chemical Properties,Usage,Production
Synthesis
876-88-0
68211-15-4
General procedure for the synthesis of 4-chloro-6-bromocinnoline from 6-bromocinnolin-4-ol: Thionyl chloride (3 mL) and N,N-dimethylformamide (30 μL) were sequentially added to 6-bromoquinolin-4(1H)-one (300 mg, 1.33 mmol), and the reaction mixture was heated to reflux for 30 min. After completion of the reaction, the reaction solution was concentrated under reduced pressure and saturated aqueous sodium bicarbonate was added to the residue and extracted with ethyl acetate. The organic layers were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and distilled under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 4-chloro-6-bromocinnoline (288 mg, 89% yield) as a yellow solid.
References
[1] Patent: JP6378918, 2018, B2. Location in patent: Paragraph 0721; 0724
[2] Patent: US2015/259331, 2015, A1. Location in patent: Paragraph 0192
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 20, p. 6832 - 6846
[4] Patent: US2003/187026, 2003, A1
[5] Journal of the Chemical Society, 1950, p. 384,389
6-bromo-4-chlorocinnoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-bromo-4-chlorocinnoline manufacturers
- Product
- 6-bromo-4-chlorocinnoline 68211-15-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20tons
- Release date
- 2019-09-05