6-chloro-5-iodonicotinic acid
- Product Name
- 6-chloro-5-iodonicotinic acid
- CAS No.
- 59782-87-5
- Chemical Name
- 6-chloro-5-iodonicotinic acid
- Synonyms
- 5-Iod-6-chlornicotinsaeure;6-chloro-5-iodonicotinic acid;6-chloro-5-iodopyridine-3-carboxylicaci;6-Chloro-5-iodo-3-pyridinecarboxylic acid;6-chloro-5-iodopyridine-3-carboxylic acid;6-Chloro-5-iodo-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-5-iodo-
- CBNumber
- CB71541457
- Molecular Formula
- C6H3ClINO2
- Formula Weight
- 283.45
- MOL File
- 59782-87-5.mol
6-chloro-5-iodonicotinic acid Property
- Melting point:
- 196-198°
- Boiling point:
- 411.8±45.0 °C(Predicted)
- Density
- 2.193±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.89±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 046180
- Product name
- 6-Chloro-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 046180
- Product name
- 6-Chloro-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- Y6596
- Product name
- 6-Chloro-5-iodonicotinicacid
- Packaging
- 5g
- Price
- $404
- Updated
- 2021/12/16
- Product number
- 046180
- Product name
- 6-Chloro-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 5g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- HCH0068444
- Product name
- 6-CHLORO-5-IODONICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $791.52
- Updated
- 2021/12/16
6-chloro-5-iodonicotinic acid Chemical Properties,Usage,Production
Synthesis
59782-91-1
59782-87-5
General procedure for the synthesis of 5-iodo-6-chloronicotinic acid from 2-chloro-3-iodo-5-methylpyridine: 2-chloro-3-iodo-5-methylpyridine (4.00 g, 15.8 mmol) was dissolved in water (160 mL), and heated at 80 °C until completely dissolved. Potassium permanganate (6.24 g, 39.5 mmol) was added in batches and the reaction mixture was heated to reflux at 100 °C for 3 hours. Upon completion of the reaction, the hot reaction solution was filtered through Celite 545 and the filter cake was washed with hot water (3 x 20 mL). The filtrates were combined, concentrated to half the original volume and subsequently cooled to 0 °C. The pH was adjusted to 1-2 by slow dropwise addition of concentrated aqueous hydrochloric acid (37%, w/w). the precipitate precipitated was collected by filtration, washed with cold water (2 × 5 mL) and dried in a vacuum desiccator to afford 6-chloro-5-iodonicotinic acid (795 mg, 2.8 mmol) as a white solid in 18% yield. The product characterization data were as follows: thin-layer chromatography Rf value (ethyl acetate/cyclohexane, 5/5, v/v) 0.40; melting point 208-210 °C (literature value: 198-200 °C); infrared spectroscopy (KBr) ν 851, 1283, 1365, 1701, 2400-3100 cm-1; 1H NMR (200 MHz, DMSO-d6) δ 8.65 (d, 1H, J = 2.0 Hz, H-4), 8.83 (d, 1H, J = 2.0 Hz, H-2); 13C NMR (50 MHz, DMSO-d6) δ 96.0 (C-5), 126.9 (C-3), 149.4 (C-4 or C-2), 149.6 (C-4 or C-2), 157.1 (C-6) 164.3 (C=O); ESI-MS m/z 281.87 [M-H]-.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
6-chloro-5-iodonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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