ChemicalBook > CAS DataBase List > 6-chloro-5-iodonicotinic acid

6-chloro-5-iodonicotinic acid

Product Name: 6-chloro-5-iodonicotinic acid
CAS No.: 59782-87-5
Chemical Name: 6-chloro-5-iodonicotinic acid
Synonyms: 5-Iod-6-chlornicotinsaeure;6-chloro-5-iodonicotinic acid;6-chloro-5-iodopyridine-3-carboxylicaci;6-Chloro-5-iodo-3-pyridinecarboxylic acid;6-chloro-5-iodopyridine-3-carboxylic acid;6-Chloro-5-iodo-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-5-iodo-
CBNumber: CB71541457
Molecular Formula: C6H3ClINO2
Formula Weight: 283.45
MOL File: 59782-87-5.mol

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6-chloro-5-iodonicotinic acid Property

Melting point:: 196-198°
Boiling point:: 411.8±45.0 °C(Predicted)
Density: 2.193±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 2.89±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 046180
Product name: 6-Chloro-5-iodonicotinic acid
Purity: >95%
Packaging: 500mg
Price: $195
Updated: 2021/12/16

Matrix Scientific

Product number: 046180
Product name: 6-Chloro-5-iodonicotinic acid
Purity: >95%
Packaging: 1g
Price: $300
Updated: 2021/12/16

AK Scientific

Product number: Y6596
Product name: 6-Chloro-5-iodonicotinicacid
Packaging: 5g
Price: $404
Updated: 2021/12/16

Matrix Scientific

Product number: 046180
Product name: 6-Chloro-5-iodonicotinic acid
Purity: >95%
Packaging: 5g
Price: $600
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0068444
Product name: 6-CHLORO-5-IODONICOTINIC ACID
Purity: 95.00%
Packaging: 500MG
Price: $791.52
Updated: 2021/12/16

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6-chloro-5-iodonicotinic acid Chemical Properties,Usage,Production

Synthesis

59782-91-1

59782-87-5

General procedure for the synthesis of 5-iodo-6-chloronicotinic acid from 2-chloro-3-iodo-5-methylpyridine: 2-chloro-3-iodo-5-methylpyridine (4.00 g, 15.8 mmol) was dissolved in water (160 mL), and heated at 80 °C until completely dissolved. Potassium permanganate (6.24 g, 39.5 mmol) was added in batches and the reaction mixture was heated to reflux at 100 °C for 3 hours. Upon completion of the reaction, the hot reaction solution was filtered through Celite 545 and the filter cake was washed with hot water (3 x 20 mL). The filtrates were combined, concentrated to half the original volume and subsequently cooled to 0 °C. The pH was adjusted to 1-2 by slow dropwise addition of concentrated aqueous hydrochloric acid (37%, w/w). the precipitate precipitated was collected by filtration, washed with cold water (2 × 5 mL) and dried in a vacuum desiccator to afford 6-chloro-5-iodonicotinic acid (795 mg, 2.8 mmol) as a white solid in 18% yield. The product characterization data were as follows: thin-layer chromatography Rf value (ethyl acetate/cyclohexane, 5/5, v/v) 0.40; melting point 208-210 °C (literature value: 198-200 °C); infrared spectroscopy (KBr) ν 851, 1283, 1365, 1701, 2400-3100 cm-1; 1H NMR (200 MHz, DMSO-d6) δ 8.65 (d, 1H, J = 2.0 Hz, H-4), 8.83 (d, 1H, J = 2.0 Hz, H-2); 13C NMR (50 MHz, DMSO-d6) δ 96.0 (C-5), 126.9 (C-3), 149.4 (C-4 or C-2), 149.6 (C-4 or C-2), 157.1 (C-6) 164.3 (C=O); ESI-MS m/z 281.87 [M-H]-.

References

[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838

6-chloro-5-iodonicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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59782-87-5, 6-chloro-5-iodonicotinic acidRelated Search:

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59782-87-5

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