ChemicalBook > CAS DataBase List > 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Product Name
1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.
252882-60-3
Chemical Name
1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
Synonyms
-piperidine;1’-Boc-spiro[indoline-3,4’-piperidin]-2-one;-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4’Spiro[indole-3,4'-piperidin]-2(1H)-one,N1'-BOCprotected;1'-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4'-piperidine];tert-butyl 2-oxospiro[indoline-3.4-piperidine]-1-carboxylate;tert-butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;tert-butyl 2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate;tert-butyl 2-oxo-1,2-dihydrospiro[indole-3,4'- piperidine]-1'-carboxylate;tert-Butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B13047]
CBNumber
CB71556389
Molecular Formula
C17H22N2O3
Formula Weight
302.37
MOL File
252882-60-3.mol
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1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Property

Boiling point:
475.6±45.0 °C(Predicted)
Density 
1.22±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
pka
13.83±0.20(Predicted)
form 
powder
color 
Yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B201830
Product name
1''-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4''-piperidine]
Packaging
100mg
Price
$295
Updated
2021/12/16
Apolloscientific
Product number
OR16702
Product name
Spiro[indole-3,4'-piperidin]-2(1H)-one,N1'-BOCprotected
Purity
95%
Packaging
5g
Price
$462
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143625
Product name
tert-Butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
Packaging
2g
Price
$613
Updated
2021/12/16
Apolloscientific
Product number
OR16702
Product name
Spiro[indole-3,4'-piperidin]-2(1H)-one,N1'-BOCprotected
Purity
95%
Packaging
250mg
Price
$51
Updated
2021/12/16
AK Scientific
Product number
J54936
Product name
1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
Packaging
250mg
Price
$55
Updated
2021/12/16
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1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

252882-61-4

24424-99-5

252882-60-3

Spiro[indoline-3,4'-piperidin]-2-one (2.73 g, 11.42 mmol) and di-tert-butyl dicarbonate (2.74 g, 12.57 mmol) were used as the raw materials. Spiro[indoline-3,4'-piperidin]-2-one was dissolved in tetrahydrofuran (100 mL), and then di-tert-butyl dicarbonate and triethylamine (2.38 mL, 17.135 mmol) were added in turn at room temperature. 17.135 mmol). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was treated with a mixture of water and dichloromethane. The aqueous layer was extracted three times with dichloromethane, the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give tert-butyl 2-oxospiro[dihydroindole-3,4'-piperidine]-1'-carboxylate (4.02 g, quantitative yield) as a white foam. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 1.44 (s, 9H), 1.56-1.73 (m, 4H), 3.55-3.79 (m, 4H), 6.86 (dd, J = 7.70, 0.40 Hz, 1H), 6.95 (td, J = 7.59, 1.10 Hz, 1H), 7.19 (td , J = 7.70, 1.10 Hz, 1H), 7.43 (dd, J = 6.80, 0.70 Hz, 1H), 10.41 (br.s., 1H); m/z = 303.05 (M + H).

References

[1] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 36; 37

1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

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View Lastest Price from 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

Career Henan Chemical Co
Product
1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 252882-60-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

252882-60-3, 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:

2,3-dihydrospiro[indene-1,3'-pyrrolidine]-3-one tert-butyl 4-oxa-1,9-diazaspiro[5.5]undecane-9-carboxylate 8-Boc-2,8-diaza-spiro[4.5]decane heMioxalate N-BOC-7-BENZYL-2,7-DIAZASPIRO[3.5]NONANE Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate 1'-Boc-5-BroMo-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] 5-CHLORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 1,2-DIHYDRO-5-METHOXY-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

  • 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
  • tert-butyl 2-oxospiro[indoline-3.4-piperidine]-1-carboxylate
  • 1,1-DiMethylethyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate
  • Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-, 1,1-diMethylethyl ester
  • tert-butyl 2-oxo-1,2-dihydrospiro[indole-3,4'- piperidine]-1'-carboxylate
  • Spiro[indole-3,4'-piperidin]-2(1H)-one,N1'-BOCprotected
  • 1,1-Dimethylethyl1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate/tert-butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
  • tert-butyl 2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate
  • 1’-Boc-spiro[indoline-3,4’-piperidin]-2-one
  • tert-Butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate
  • -Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4&rsquo
  • -piperidine
  • 1'-Boc-1,2-dihydro-2-oxo-spiro[3h-indole-3,4'-piperidine]
  • tert-butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
  • ? Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester
  • 1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate
  • tert-Butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B13047]
  • 252882-60-3